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Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D

Angewandte Chemie International Edition, 2018-11, Vol.57 (47), p.15572-15576

International ed. in English, 2018

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Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform

Cancers, 2019-05, Vol.11 (6), p.739

2019

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Scaffold-Hopping Strategy: Synthesis and Biological Evaluation of 5,6-Fused Bicyclic Heteroaromatics To Identify Orally Bioavailable Anticancer Agents

Journal of medicinal chemistry, 2011-04, Vol.54 (8), p.3076-3080

2011

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Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

Journal of medicinal chemistry, 2010-10, Vol.53 (20), p.7316-7326

2010

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Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.E1779-E1787

2013

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Optimization of Ligand and Lipophilic Efficiency To Identify an in Vivo Active Furano-Pyrimidine Aurora Kinase Inhibitor

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5247-5260

2013

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First Total Syntheses of (±)-Annuionone B and (±)-Tanarifuranonol

Organic letters, 2008-02, Vol.10 (3), p.449-452

2008

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Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

Journal of Virology, 2011-09, Vol.85 (17), p.9114-9126

2011

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Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3889-3903

2013

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3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor

ChemMedChem, 2013-01, Vol.8 (1), p.136-148

2013

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BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

PloS one, 2011-08, Vol.6 (8), p.e23485

2011

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Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer

Expert opinion on investigational drugs, 2014-10, Vol.23 (10), p.1333-1348

2014

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Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10108-10123

2019

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Domino retro Diels-Alder/Diels-Alder reaction: an efficient protocol for the synthesis of highly functionalized bicyclo[2.2.2]octenones and bicyclo[2.2.2]octadienones

Organic & biomolecular chemistry, 2006-01, Vol.4 (11), p.2267-2277

2006

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Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease

European journal of medicinal chemistry, 2023-10, Vol.258, p.115583-115583, Article 115583

2023

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Facile Identification of Dual FLT3-Aurora A Inhibitors: A Computer-Guided Drug Design Approach

ChemMedChem, 2014-05, Vol.9 (5), p.953-961

2014

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Anti-Influenza Drug Discovery: Structure−Activity Relationship and Mechanistic Insight into Novel Angelicin Derivatives

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1519-1533

2010

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Discovery of Conformational Control Inhibitors Switching off the Activated c‑KIT and Targeting a Broad Range of Clinically Relevant c‑KIT Mutants

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.3940-3957

2019

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Drug repurposing for chronic myeloid leukemia: in silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors

Journal of biomolecular structure & dynamics, 2017-06, Vol.35 (8), p.1833-1848

2017

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Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11135-11150

2019

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An Efficient, Mild and Scalable Synthesis of Bioactive Compounds Containing the Angelicin Scaffold

Journal of the Chinese Chemical Society (Taipei), 2012-12, Vol.59 (12), p.1548-1554

2012

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Anti-influenza Drug Discovery: Identification of an Orally Bioavailable Quinoline Derivative through Activity- and Property-Guided Lead Optimization

ChemMedChem, 2012-09, Vol.7 (9), p.1546-1550

2012

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Fast-Forwarding Hit to Lead: Aurora and Epidermal Growth Factor Receptor Kinase Inhibitor Lead Identification

Journal of medicinal chemistry, 2010-07, Vol.53 (13), p.4980-4988

2010

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Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists

ChemMedChem, 2010-10, Vol.5 (10), p.1707-1716

2010

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Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D

Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform

Scaffold-Hopping Strategy: Synthesis and Biological Evaluation of 5,6-Fused Bicyclic Heteroaromatics To Identify Orally Bioavailable Anticancer Agents

Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Optimization of Ligand and Lipophilic Efficiency To Identify an in Vivo Active Furano-Pyrimidine Aurora Kinase Inhibitor

First Total Syntheses of (±)-Annuionone B and (±)-Tanarifuranonol

Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors

3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor

BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer

Domino retro Diels-Alder/Diels-Alder reaction: an efficient protocol for the synthesis of highly functionalized bicyclo[2.2.2]octenones and bicyclo[2.2.2]octadienones

Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease

Facile Identification of Dual FLT3-Aurora A Inhibitors: A Computer-Guided Drug Design Approach

Anti-Influenza Drug Discovery: Structure−Activity Relationship and Mechanistic Insight into Novel Angelicin Derivatives

Discovery of Conformational Control Inhibitors Switching off the Activated c‑KIT and Targeting a Broad Range of Clinically Relevant c‑KIT Mutants

Drug repurposing for chronic myeloid leukemia: in silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia

An Efficient, Mild and Scalable Synthesis of Bioactive Compounds Containing the Angelicin Scaffold

Anti-influenza Drug Discovery: Identification of an Orally Bioavailable Quinoline Derivative through Activity- and Property-Guided Lead Optimization

Fast-Forwarding Hit to Lead: Aurora and Epidermal Growth Factor Receptor Kinase Inhibitor Lead Identification

Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

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