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Antibody-Enzyme Conjugates for Cancer Therapy

JNCI : Journal of the National Cancer Institute, 1996-02, Vol.88 (3-4), p.153-165

1996

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A cytotoxic agent can be generated selectively at cancer sites

British journal of cancer, 1988-12, Vol.58 (6), p.700-703

1988

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Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase

Biochemical pharmacology, 1995-08, Vol.50 (5), p.609-618

1995

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Optimization of small-scale coupling of A5B7 monoclonal antibody to carboxypeptidase G2

Journal of immunological methods, 1993-01, Vol.158 (1), p.49-56

1993

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Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia coli and Pseudomonas putida

Journal of Bacteriology, 1983-12, Vol.156 (3), p.1222-1227

1983

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I: Purification and properties of a nitroreductase enzyme from Escherichia coli—A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)

Biochemical pharmacology, 1992-12, Vol.44 (12), p.2289-2295

1992

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Galactosylated antibodies and antibody‐enzyme conjugates in antibody‐directed enzyme prodrug therapy

Cancer, 1994-02, Vol.73 (S3), p.1114-1120

1994

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Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT)

Biochemical pharmacology, 1995-05, Vol.49 (11), p.1641-1647

1995

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Antibody directed enzyme prodrug therapy (ADEPT): clinical report

Disease markers, 1991-05, Vol.9 (3-4), p.233

1991

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—II: A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

Biochemical pharmacology, 1992-12, Vol.44 (12), p.2297-2301

1992

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Advanced drug delivery reviews: enzyme prodrug therapy

Advanced drug delivery reviews, 1996-12, Vol.22 (3), p.269-288

Sherwood, Roger F.

1996

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The potential of carboxypeptidase G2 : antibody conjugates as anti-tumour agents. II: In vivo localising and clearance properties in a choriocarcinoma model

British journal of cancer, 1990-03, Vol.61 (3), p.420-424

1990

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Covalent linkage of carboxypeptidase G2 to soluble dextrans. I: Properties of conjugates and effects on plasma persistence in mice

Biochemical pharmacology, 1987, Vol.36 (1), p.105-112

1987

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Antibody directed enzyme prodrug therapy (ADEPT): a three phase system

Disease markers, 1991-05, Vol.9 (3-4), p.225

1991

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The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2

Gene, 1984-11, Vol.31 (1), p.31-38

1984

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Tumour necrosis factor increases tumour uptake of co-administered antibody-carboxypeptidase G2 conjugate

European journal of cancer (1990), 1993, Vol.29A (8), p.1177-1183

1993

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Covalent linkage of carboxypeptidase G2 to soluble dextrans. II: In vivo distribution and fate of conjugates

Biochemical pharmacology, 1987, Vol.36 (1), p.113-121

1987

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Crystallization and preliminary crystallographic analysis of carboxypeptidase G2 from Pseudomonas sp. strain RS-16

Journal of molecular biology, 1991-07, Vol.220 (1), p.17-18

1991

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Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16: use of a novel triazine dye affinity method

European journal of biochemistry, 1985-05, Vol.148 (3), p.447-453

1985

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The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I: Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro

British journal of cancer, 1986-03, Vol.53 (3), p.377-384

1986

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Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

Cell biophysics, 1992-08, Vol.21 (1-3), p.109

1992

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Carboxypeptidase G2 and trimetrexate cause growth delay of human colonic cancer cells in vitro

Biochemical pharmacology, 1990-06, Vol.39 (11), p.1787-1791

1990

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Biochemical and biological properties of methotrexate analogs containing d-glutamic acid or d-erythro,threo-4-fluoroglutamic acid

Biochemical pharmacology, 1991-11, Vol.42 (12), p.2400-2403

1991

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Expression of the Pseudomonas gene coding for carboxypeptidase G2 in Saccharomyces cerevisiae

Journal of general microbiology, 1985-04, Vol.131 (4), p.897

1985

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Metal-ion-promoted binding of triazine dyes to proteins. The interaction of Cibacron Blue F3G-A with yeast hexokinase

Biochemical journal, 1982-08, Vol.205 (2), p.453-456

1982

Volltextzugriff (PDF)

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Antibody-Enzyme Conjugates for Cancer Therapy

A cytotoxic agent can be generated selectively at cancer sites

Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase

Optimization of small-scale coupling of A5B7 monoclonal antibody to carboxypeptidase G2

Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia coli and Pseudomonas putida

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I: Purification and properties of a nitroreductase enzyme from Escherichia coli—A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)

Galactosylated antibodies and antibody‐enzyme conjugates in antibody‐directed enzyme prodrug therapy

Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT)

Antibody directed enzyme prodrug therapy (ADEPT): clinical report

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—II: A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

Advanced drug delivery reviews: enzyme prodrug therapy

The potential of carboxypeptidase G2 : antibody conjugates as anti-tumour agents. II: In vivo localising and clearance properties in a choriocarcinoma model

Covalent linkage of carboxypeptidase G2 to soluble dextrans. I: Properties of conjugates and effects on plasma persistence in mice

Antibody directed enzyme prodrug therapy (ADEPT): a three phase system

The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2

Tumour necrosis factor increases tumour uptake of co-administered antibody-carboxypeptidase G2 conjugate

Covalent linkage of carboxypeptidase G2 to soluble dextrans. II: In vivo distribution and fate of conjugates

Crystallization and preliminary crystallographic analysis of carboxypeptidase G2 from Pseudomonas sp. strain RS-16

Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16: use of a novel triazine dye affinity method

The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I: Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro

Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

Carboxypeptidase G2 and trimetrexate cause growth delay of human colonic cancer cells in vitro

Biochemical and biological properties of methotrexate analogs containing d-glutamic acid or d-erythro,threo-4-fluoroglutamic acid

Expression of the Pseudomonas gene coding for carboxypeptidase G2 in Saccharomyces cerevisiae

Metal-ion-promoted binding of triazine dyes to proteins. The interaction of Cibacron Blue F3G-A with yeast hexokinase

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