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Computational protein design enables a novel one-carbon assimilation pathway

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (12), p.3704-3709

2015

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Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

Nature biotechnology, 2012-02, Vol.30 (2), p.190-192

2012

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A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

Cell, 2014-06, Vol.157 (7), p.1644-1656

2014

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Control of repeat-protein curvature by computational protein design

Nature structural & molecular biology, 2015-02, Vol.22 (2), p.167-174

2015

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The tertiary structure and domain organization of coagulation factor VIII

Blood, 2008-02, Vol.111 (3), p.1240-1247

2008

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Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity

Structure (London), 2016-06, Vol.24 (6), p.862-873

2016

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Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Communications biology, 2021-10, Vol.4 (1), p.1240-1240, Article 1240

2021

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Structure of the C2 domain of human factor VIII at 1.5 resolution

Nature (London), 1999-11, Vol.402 (6760), p.439-442

1999

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Unusual Target Site Disruption by the Rare-Cutting HNH Restriction Endonuclease PacI

Structure (London), 2010-06, Vol.18 (6), p.734-743

2010

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The Crystal Structure and Mutational Analysis of Human NUDT9

Journal of molecular biology, 2003-09, Vol.332 (2), p.385-398

2003

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Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor

Nucleic acids research, 2023-05, Vol.51 (8), p.3513-3528

2023

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Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM

Structure (London), 2021-06, Vol.29 (6), p.521-530.e5

2021

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Engineering and functionalization of large circular tandem repeat protein nanoparticles

Nature structural & molecular biology, 2020-04, Vol.27 (4), p.342-350

2020

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Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI

Nucleic acids research, 2019-01, Vol.47 (1), p.450-467

2019

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The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease

Journal of molecular biology, 2016-01, Vol.428 (1), p.206-220

2016

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DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target

Nucleic acids research, 2017-02, Vol.45 (3), p.1516-1528

2017

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Crystal structure of human recombinant ornithine aminotransferase

Journal of molecular biology, 1998-03, Vol.277 (1), p.81-102

1998

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Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI

Nucleic acids research, 2011-10, Vol.39 (18), p.8223-8236

2011

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DNA Binding and Cleavage by the HNH Homing Endonuclease I-HmuI

Journal of molecular biology, 2004-09, Vol.342 (1), p.43-56

2004

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Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space

Nucleic acids research, 2012-06, Vol.40 (11), p.4954-4964

2012

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The Structure of a Bacterial DUF199/WhiA Protein: Domestication of an Invasive Endonuclease

Structure (London), 2009-10, Vol.17 (10), p.1368-1376

2009

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Thermodynamics of DNA target site recognition by homing endonucleases

Nucleic acids research, 2007-12, Vol.35 (21), p.7209-7221

2007

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I-BasI and I-HmuI: Two Phage Intron-encoded Endonucleases with Homologous DNA Recognition Sequences but Distinct DNA Specificities

Journal of molecular biology, 2006-05, Vol.358 (4), p.1137-1151

2006

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Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition

Structure (London), 1997-08, Vol.5 (8), p.1067-1075

1997

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Computational protein design enables a novel one-carbon assimilation pathway

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

Control of repeat-protein curvature by computational protein design

The tertiary structure and domain organization of coagulation factor VIII

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity

Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Structure of the C2 domain of human factor VIII at 1.5 resolution

Unusual Target Site Disruption by the Rare-Cutting HNH Restriction Endonuclease PacI

The Crystal Structure and Mutational Analysis of Human NUDT9

Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor

Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM

Engineering and functionalization of large circular tandem repeat protein nanoparticles

Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI

The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease

DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target

Crystal structure of human recombinant ornithine aminotransferase

Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI

DNA Binding and Cleavage by the HNH Homing Endonuclease I-HmuI

Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space

The Structure of a Bacterial DUF199/WhiA Protein: Domestication of an Invasive Endonuclease

Thermodynamics of DNA target site recognition by homing endonucleases

I-BasI and I-HmuI: Two Phage Intron-encoded Endonucleases with Homologous DNA Recognition Sequences but Distinct DNA Specificities

Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition

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