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Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

Anesthesiology (Philadelphia), 2011-07, Vol.115 (1), p.189-204

2011

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Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

The New England journal of medicine, 2010-10, Vol.363 (16), p.1521-1531

2010

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Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Molecular cancer therapeutics, 2016-05, Vol.15 (5), p.958-970

2016

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Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2)

The Journal of biological chemistry, 2013-04, Vol.288 (15), p.10805-10818

2013

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Novel class of pain drugs based on antagonism of NGF

Trends in pharmacological sciences (Regular ed.), 2006-02, Vol.27 (2), p.85-91

2006

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Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates

The Journal of pharmacology and experimental therapeutics, 2012-02, Vol.340 (2), p.228-236

2012

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Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy

PloS one, 2015-07, Vol.10 (7), p.e0132282-e0132282

2015

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Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization

Pain (Amsterdam), 2005-05, Vol.115 (1), p.128-141

2005

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Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function

PloS one, 2015-04, Vol.10 (4), p.e0125127-e0125127

2015

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A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone

Cancer research (Chicago, Ill.), 2005-10, Vol.65 (20), p.9426-9435

2005

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Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments

Toxicologic pathology, 2018-06, Vol.46 (4), p.408-420

2018

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Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis

Pain (Amsterdam), 2005-07, Vol.116 (1), p.8-16

2005

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First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain

Pain reports, 2018-05, Vol.3 (3), p.e653-e653

2018

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Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin

The European journal of neuroscience, 1999-05, Vol.11 (5), p.1698-1704

1999

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Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading

Nature biotechnology, 2015-07, Vol.33 (7), p.694-696

2015

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Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates

Bioconjugate chemistry, 2015-04, Vol.26 (4), p.650-659

2015

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The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule

Nature medicine, 1995-08, Vol.1 (8), p.774-780

1995

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Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates

Bioconjugate chemistry, 2014-02, Vol.25 (2), p.240-250

2014

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Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

The Journal of biological chemistry, 2016-07, Vol.291 (27), p.13974-13986

2016

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The Glial Cell Line-Derived Neurotrophic Factor Family Receptor Components Are Differentially Regulated within Sensory Neurons after Nerve Injury

The Journal of neuroscience, 2000-01, Vol.20 (1), p.427-437

2000

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Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model

Annals of the rheumatic diseases, 2017-01, Vol.76 (1), p.295-302

2017

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Precise and Efficient Antibody Epitope Determination through Library Design, Yeast Display and Next-Generation Sequencing

Journal of molecular biology, 2015-03, Vol.427 (6), p.1513-1534

2015

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Endogenous nerve growth factor regulates the sensitivity of nociceptors in the adult rat

The European journal of neuroscience, 1998-04, Vol.10 (4), p.1282-1291

1998

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Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates

Scientific reports, 2019-02, Vol.9 (1), p.2443-2443, Article 2443

2019

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RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models

Oncotarget, 2018-09, Vol.9 (71), p.33446-33458

2018

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Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2)

Novel class of pain drugs based on antagonism of NGF

Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy

Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization

Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function

A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone

Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic Assessments

Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis

First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain

Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin

Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading

Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates

The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule

Mass Spectrometric Characterization of Transglutaminase Based Site-Specific Antibody–Drug Conjugates

Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

The Glial Cell Line-Derived Neurotrophic Factor Family Receptor Components Are Differentially Regulated within Sensory Neurons after Nerve Injury

Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model

Precise and Efficient Antibody Epitope Determination through Library Design, Yeast Display and Next-Generation Sequencing

Endogenous nerve growth factor regulates the sensitivity of nociceptors in the adult rat

Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates

RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models

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