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Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells

British journal of pharmacology, 1999-09, Vol.128 (1), p.13-20

1999

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Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation

Diabetes (New York, N.Y.), 1998-04, Vol.47 (4), p.612-620

1998

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Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats

Journal of cerebral blood flow and metabolism, 1993-03, Vol.13 (2), p.183

1993

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2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia

Science (American Association for the Advancement of Science), 1990-02, Vol.247 (4942), p.571-574

1990

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AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h

European journal of pharmacology, 1993-06, Vol.236 (3), p.347-353

1993

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Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors

The Journal of pharmacology and experimental therapeutics, 1994-04, Vol.269 (1), p.271

1994

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The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat

The Journal of pharmacology and experimental therapeutics, 2001-11, Vol.299 (2), p.782

2001

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Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2274-2283

1992

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The triggering of spreading depression in the chicken retina: a pharmacological study

Brain research, 1993-04, Vol.607 (1), p.189-194

Sheardown, Malcolm J.

1993

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Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice

European journal of pharmacology, 2000-08, Vol.402 (3), p.241-246

2000

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Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects

Brain research, 1998-06, Vol.795 (1), p.179-190

1998

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Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

European journal of pharmacology, 1998-09, Vol.356 (2), p.109-119

1998

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The triggering of spreading depression in the chick retina by nicotinic receptor agonists

European journal of pharmacology, 1997-10, Vol.337 (2), p.209-212

Sheardown, Malcolm J

1997

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Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4378-4384

1998

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Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232)

The Journal of pharmacology and experimental therapeutics, 1994-04, Vol.269 (1), p.282

1994

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Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex

Neuroreport, 1992-10, Vol.3 (10), p.916-918

Sheardown, Malcolm J

1992

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Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats

Neuroreport, 1998-10, Vol.9 (15), p.3481-3486

1998

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The pharmacology of AMPA receptors and their antagonists

Stroke (1970), 1993-12, Vol.24 (12 Suppl), p.I146-7; discussion I153-4

Sheardown, M J

1993

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Modulation of γ-aminobutyric acid responses in the rat optic nerve

European journal of pharmacology, 2000-08, Vol.401 (3), p.339-342

2000

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Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.538-546

1997

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Protection against post-ischemic behavioral pathology by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil

Neuroscience letters, 1991-12, Vol.133 (2), p.291-294

1991

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N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects

Journal of medicinal chemistry, 1999-09, Vol.42 (18), p.3463-3477

1999

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Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.687-692

1991

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Amino acid receptor mediated excitatory synaptic transmission in the cat red nucleus

The Journal of physiology, 1986-07, Vol.376 (1), p.13-29

1986

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Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2897-2902

1998

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Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation

Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia

AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors

The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

The triggering of spreading depression in the chicken retina: a pharmacological study

Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice

Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

The triggering of spreading depression in the chick retina by nicotinic receptor agonists

Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232)

Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex

Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats

The pharmacology of AMPA receptors and their antagonists

Modulation of γ-aminobutyric acid responses in the rat optic nerve

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Protection against post-ischemic behavioral pathology by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil

N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects

Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships

Amino acid receptor mediated excitatory synaptic transmission in the cat red nucleus

Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation

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