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Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

The Journal of biological chemistry, 2013-06, Vol.288 (26), p.18707-18715

2013

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Oxysterols: From physiological tuners to pharmacological opportunities

British journal of pharmacology, 2021-08, Vol.178 (16), p.3089-3103

2021

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Oxysterols: Old Tale, New Twists

Annual review of pharmacology and toxicology, 2016-01, Vol.56 (1), p.447-467

2016

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The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally[S]

Journal of lipid research, 2015-04, Vol.56 (4), p.888-897

2015

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Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

Progress in lipid research, 2013-10, Vol.52 (4), p.666-680

2013

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Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation

The Journal of biological chemistry, 2019-02, Vol.294 (7), p.2436-2448

2019

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The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally

Journal of lipid research, 2022-12, Vol.63 (12), p.100295, Article 100295

2022

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The UPS and downs of cholesterol homeostasis

Trends in biochemical sciences (Amsterdam. Regular ed.), 2014-11, Vol.39 (11), p.527-535

2014

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Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Journal of lipid research, 2023-05, Vol.64 (5), p.100362-100362, Article 100362

2023

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Akt acutely activates the cholesterogenic transcription factor SREBP-2

Biochimica et biophysica acta, 2012-02, Vol.1823 (2), p.458-464

2012

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The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2014-10, Vol.1841 (10), p.1431-1439

2014

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The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters

The Journal of biological chemistry, 2015-10, Vol.290 (40), p.24604-24613

2015

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Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]

Journal of lipid research, 2014-03, Vol.55 (3), p.410-420

2014

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Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

The Journal of biological chemistry, 2016-04, Vol.291 (16), p.8363-8373

2016

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Post-translational control of the long and winding road to cholesterol

The Journal of biological chemistry, 2020-12, Vol.295 (51), p.17549-17559

2020

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New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2017-07, Vol.1862 (7), p.647-657

2017

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Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt

Biochemical journal, 2012-10, Vol.447 (1), p.51-60

2012

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DHCR7: A vital enzyme switch between cholesterol and vitamin D production

Progress in lipid research, 2016-10, Vol.64, p.138-151

2016

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DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme

Bioscience reports, 2014-04, Vol.34 (2)

2014

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The Akt–SREBP nexus: cell signaling meets lipid metabolism

Trends in endocrinology and metabolism, 2010-05, Vol.21 (5), p.268-276

2010

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Norovirus RNA-Dependent RNA Polymerase Is Phosphorylated by an Important Survival Kinase, Akt

Journal of Virology, 2011-10, Vol.85 (20), p.10894-10898

2011

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The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2021-01, Vol.1866 (1), p.158837-158837, Article 158837

2021

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Controlling an E3 ligase and its substrate: A function for MARCHF6 circRNA

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2023-01, Vol.1868 (1), p.159237-159237, Article 159237

2023

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A paREDOX in the control of cholesterol biosynthesis: Does the NADPH sensor and E3 ubiquitin ligase MARCHF6 protect mammalian cells during oxidative stress by controlling sterol biosynthesis?

BioEssays, 2024-07, Vol.46 (7), p.e2400073

2024

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The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

Molecular and cellular biology, 2014-04, Vol.34 (7), p.1262-1270

2014

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Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

Oxysterols: From physiological tuners to pharmacological opportunities

Oxysterols: Old Tale, New Twists

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally[S]

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation

The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally

The UPS and downs of cholesterol homeostasis

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Akt acutely activates the cholesterogenic transcription factor SREBP-2

The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis

The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

Post-translational control of the long and winding road to cholesterol

New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis

Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt

DHCR7: A vital enzyme switch between cholesterol and vitamin D production

DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme

The Akt–SREBP nexus: cell signaling meets lipid metabolism

Norovirus RNA-Dependent RNA Polymerase Is Phosphorylated by an Important Survival Kinase, Akt

The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond

Controlling an E3 ligase and its substrate: A function for MARCHF6 circRNA

A paREDOX in the control of cholesterol biosynthesis: Does the NADPH sensor and E3 ubiquitin ligase MARCHF6 protect mammalian cells during oxidative stress by controlling sterol biosynthesis?

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

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