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Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Biochemistry (Easton), 2019-02, Vol.58 (7), p.900-907

2019

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Chutes and ladders in hepatitis C nucleoside drug development

Antiviral research, 2014-02, Vol.102, p.119-147

2014

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Diastereoselective Synthesis of 2′-Dihalopyrimidine Ribonucleoside Inhibitors of Hepatitis C Virus Replication

ACS omega, 2022-01, Vol.7 (1), p.1452-1461

2022

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(Z)- and (E)-2-(1,2-Dihydroxyethyl)methylenecyclopropane Analogues of 2′-Deoxyadenosine and 2′-Deoxyguanosine. Synthesis of All Stereoisomers, Absolute Configuration, and Antiviral Activity

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3397-3407

2009

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Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus

Infectious disorders drug targets, 2018, Vol.18 (3), p.224-232

2018

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In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication

Antimicrobial Agents and Chemotherapy, 2005-03, Vol.49 (3), p.1039-1045

2005

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9-{[3-Fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and Antiviral Activity of All Stereoisomers

Journal of medicinal chemistry, 2006-10, Vol.49 (20), p.6120-6128

2006

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(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a New Class of Methylenecyclopropane Analogues of Nucleosides: Synthesis and Antiviral Activity

Journal of medicinal chemistry, 2004-12, Vol.47 (27), p.6964-6972

2004

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The premise of capsid assembly modulators towards eliminating HBV persistence

Expert opinion on drug discovery, 2023-09, Vol.18 (9), p.1031-1041

2023

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Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease

European journal of medicinal chemistry, 2024-03, Vol.268, p.116263, Article 116263

2024

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Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs)

Bioorganic chemistry, 2023-12, Vol.141, p.106923-106923, Article 106923

2023

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2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5424-5437

2017

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Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (12), p.2165-2170

2018

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Synthesis and anti-HCV activity of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs

Bioorganic & medicinal chemistry, 2019-02, Vol.27 (4), p.664-676

2019

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Intracellular metabolism and potential cardiotoxicity of a β-D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication

Nucleosides, nucleotides & nucleic acids, 2020-02, Vol.39 (1-3), p.204-224

2020

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A new alkylation–elimination method for synthesis of antiviral fluoromethylenecyclopropane analogues of nucleosides

Tetrahedron, 2005-07, Vol.61 (30), p.7112-7116

2005

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Methylene-2-ethynylcyclopropanes: synthesis and biological activity of ( Z)- and ( E)-9-{[2-ethynyl-2-(hydroxymethyl)cyclopropylidene]methyl}adenine and -guanine

Tetrahedron, 2007-09, Vol.63 (38), p.9406-9412

2007

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Stereoselective Approach to the Z-Isomers of Methylenecyclopropane Analogues of Nucleosides: A New Synthesis of Antiviral Synguanol

Nucleosides, nucleotides & nucleic acids, 2009-03, Vol.28 (3), p.165-174

2009

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Synthesis and Antiviral Activity of (Z)- and (E)-2,2-[Bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: Second-Generation Methylenecyclopropane Analogues of Nucleosides

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.566-575

2004

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Synthesis of methylenecyclopropane analogues of antiviral nucleoside phosphonates

Tetrahedron, 2006-03, Vol.62 (11), p.2608-2615

2006

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Synthesis Of 2,2,3-Tris(Hydroxymethyl)Methylenecyclopropane Analogues Of Nucleosides

Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (4), p.391-402

2007

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Fluoroanalogues of Anti-Cytomegalovirus Agent Cyclopropavir: Synthesis and Antiviral Activity of (E)- and (Z)-9-{[2,2-Bis(Hydroxymethyl)-3-Fluorocyclopropylidene]Methyl}-Adenines and Guanines

Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (3), p.231-243

2007

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9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1

Journal of medicinal chemistry, 2006-10, Vol.49 (20), p.6120-6128

2006

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ChemInform Abstract: Stereoselective Approach to the Z-Isomers of Methylenecyclopropane Analogues of Nucleosides: A New Synthesis of Antiviral Synguanol

ChemInform, 2009-10, Vol.40 (40), p.no-no

2009

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Fluoroanalogues of anti-Cytomegalovirus Agent Cyclopropavir: Synthesis and Antiviral Activity of (E)- and (Z)-9-{[2,2-Bis(hydroxymethyl)-3-fluorocyclopropylidene] methyl}-adenines and Guanines

ChemInform, 2007-09, Vol.38 (36), p.no-no

2007

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Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Chutes and ladders in hepatitis C nucleoside drug development

Diastereoselective Synthesis of 2′-Dihalopyrimidine Ribonucleoside Inhibitors of Hepatitis C Virus Replication

(Z)- and (E)-2-(1,2-Dihydroxyethyl)methylenecyclopropane Analogues of 2′-Deoxyadenosine and 2′-Deoxyguanosine. Synthesis of All Stereoisomers, Absolute Configuration, and Antiviral Activity

Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus

In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication

9-{[3-Fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and Antiviral Activity of All Stereoisomers

(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a New Class of Methylenecyclopropane Analogues of Nucleosides: Synthesis and Antiviral Activity

The premise of capsid assembly modulators towards eliminating HBV persistence

Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease

Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs)

2′-Chloro,2′-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture

Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors

Synthesis and anti-HCV activity of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs

Intracellular metabolism and potential cardiotoxicity of a β-D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication

A new alkylation–elimination method for synthesis of antiviral fluoromethylenecyclopropane analogues of nucleosides

Methylene-2-ethynylcyclopropanes: synthesis and biological activity of ( Z)- and ( E)-9-{[2-ethynyl-2-(hydroxymethyl)cyclopropylidene]methyl}adenine and -guanine

Stereoselective Approach to the Z-Isomers of Methylenecyclopropane Analogues of Nucleosides: A New Synthesis of Antiviral Synguanol

Synthesis and Antiviral Activity of (Z)- and (E)-2,2-[Bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: Second-Generation Methylenecyclopropane Analogues of Nucleosides

Synthesis of methylenecyclopropane analogues of antiviral nucleoside phosphonates

Synthesis Of 2,2,3-Tris(Hydroxymethyl)Methylenecyclopropane Analogues Of Nucleosides

Fluoroanalogues of Anti-Cytomegalovirus Agent Cyclopropavir: Synthesis and Antiviral Activity of (E)- and (Z)-9-{[2,2-Bis(Hydroxymethyl)-3-Fluorocyclopropylidene]Methyl}-Adenines and Guanines

9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1

ChemInform Abstract: Stereoselective Approach to the Z-Isomers of Methylenecyclopropane Analogues of Nucleosides: A New Synthesis of Antiviral Synguanol

Fluoroanalogues of anti-Cytomegalovirus Agent Cyclopropavir: Synthesis and Antiviral Activity of (E)- and (Z)-9-{[2,2-Bis(hydroxymethyl)-3-fluorocyclopropylidene] methyl}-adenines and Guanines

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