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Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Science (American Association for the Advancement of Science), 2014-07, Vol.345 (6193), p.179-183

2014

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Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Journal of molecular biology, 2009-01, Vol.385 (3), p.693-713

2009

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Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (51), p.25891-25899

2019

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Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

Progress in biophysics and molecular biology, 2005-06, Vol.88 (2), p.209-231

2005

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Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects

Journal of acquired immune deficiency syndromes (1999), 2009-05, Vol.51 (1), p.20-28

2009

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Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

Structure (London), 1995-04, Vol.3 (4), p.365-379

1995

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Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

Structure (London), 1996-07, Vol.4 (7), p.853-860

1996

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

The EMBO journal, 2001-03, Vol.20 (6), p.1449-1461

2001

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Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase

Journal of Virology, 2001-05, Vol.75 (10), p.4832-4842

2001

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Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

Current opinion in structural biology, 2004-12, Vol.14 (6), p.716-730

2004

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Avian bic, a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-Induced Lymphomas That Encodes a Noncoding RNA, Cooperates with c-myc in Lymphomagenesis and Erythroleukemogenesis

Journal of Virology, 2002-05, Vol.76 (9), p.4275-4286

2002

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Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4003-4015

2007

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The RCAS vector system

Folia biologica, 2004, Vol.50 (3-4), p.107-119

Hughes, Stephen H

2004

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Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7582-7591

2005

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Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4199-4207

1997

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Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097

Journal of molecular biology, 2007-01, Vol.365 (1), p.77-89

2007

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The history of N-methanocarbathymidine: The investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent

Antiviral research, 2006-09, Vol.71 (2), p.268-275

2006

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Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

Nature structural & molecular biology, 2004-05, Vol.11 (5), p.469-474

2004

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Lamivudine (3TC) Resistance in HIV-1 Reverse Transcriptase Involves Steric Hindrance with β -Branched Amino Acids

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (18), p.10027-10032

1999

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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA

The EMBO journal, 2002-12, Vol.21 (23), p.6614-6624

2002

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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Journal of molecular biology, 2001-06, Vol.309 (2), p.437-445

2001

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Replication of Phenotypically Mixed Human Immunodeficiency Virus Type 1 Virions Containing Catalytically Active and Catalytically Inactive Reverse Transcriptase

Journal of Virology, 2001-07, Vol.75 (14), p.6537-6546

2001

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In Vitro Characterization of a Simian Immunodeficiency Virus-Human Immunodeficiency Virus (HIV) Chimera Expressing HIV Type 1 Reverse Transcriptase To Study Antiviral Resistance in Pigtail Macaques

Journal of Virology, 2004-12, Vol.78 (24), p.13553-13561

2004

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Mutations in the RNase H Domain of HIV-1 Reverse Transcriptase Affect the Initiation of DNA Synthesis and the Specificity of RNase H Cleavage in vivo

Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (14), p.9515-9520

2002

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Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase

Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

Avian bic, a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-Induced Lymphomas That Encodes a Noncoding RNA, Cooperates with c-myc in Lymphomagenesis and Erythroleukemogenesis

Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme

The RCAS vector system

Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains

Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles

Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097

The history of N-methanocarbathymidine: The investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

Lamivudine (3TC) Resistance in HIV-1 Reverse Transcriptase Involves Steric Hindrance with β -Branched Amino Acids

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Replication of Phenotypically Mixed Human Immunodeficiency Virus Type 1 Virions Containing Catalytically Active and Catalytically Inactive Reverse Transcriptase

In Vitro Characterization of a Simian Immunodeficiency Virus-Human Immunodeficiency Virus (HIV) Chimera Expressing HIV Type 1 Reverse Transcriptase To Study Antiviral Resistance in Pigtail Macaques

Mutations in the RNase H Domain of HIV-1 Reverse Transcriptase Affect the Initiation of DNA Synthesis and the Specificity of RNase H Cleavage in vivo

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