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Synthesis and Characterization of Micelle-Forming PEG-Poly(Amino Acid) Copolymers with Iron-Hydroxamate Cross-Linkable Blocks for Encapsulation and Release of Hydrophobic Drugs

Biomacromolecules, 2017-06, Vol.18 (6), p.1874-1884

2017

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Imaging the delivery of drug-loaded, iron-stabilized micelles

Nanomedicine, 2017-05, Vol.13 (4), p.1353-1362

2017

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Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus

Future medicinal chemistry, 2018-04, Vol.10 (8), p.851-862

2018

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Synthesis and facile end-group quantification of functionalized PEG azides

Journal of polymer science. Part A, Polymer chemistry, 2016-09, Vol.54 (18), p.2888-2895

2016

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Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Journal of Drug Delivery, 2016-01, Vol.2016, p.98-109

2016

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Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication

Journal of medicinal chemistry, 2011-06, Vol.54 (12), p.4119-4132

2011

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Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus Replication

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8670-8680

2011

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IT-143, A Polymer Micelle Nanoparticle, Widens Therapeutic Window of Daunorubicin

Pharmaceutical nanotechnology, 2016-04, Vol.4 (1), p.3-15

2016

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A Tribute to Prof. Madeleine Joullie

ARKIVOC, 2006-07, Vol.2007 (12), p.1-6

2006

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Large-scale synthesis of α-amino acid-N-carboxyanhydrides

Synthetic communications, 2017-01, Vol.47 (1), p.53-61

2017

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Large-scale synthesis of [alpha]-amino acid-N-carboxyanhydrides

Synthetic communications, 2017-01, Vol.47 (1), p.53

2017

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Efficient construction of novel quaternary lactam dipeptide surrogates

Tetrahedron letters, 1998-09, Vol.39 (37), p.6645-6648

Edward Semple, J.

1998

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Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2925-2930

2002

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Abstract B22: IT-141, a stabilized polymer micelle formulation, prolongs the pharmacodynamic effect of SN-38

Molecular cancer research, 2016-11, Vol.14 (11_Supplement), p.B22-B22

2016

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Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates

Bioorganic & medicinal chemistry letters, 1998-09, Vol.8 (18), p.2501-2506

SEMPLE, J. E

1998

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Abstract LB-190: IT-141 and IT-147, iron stabilized micellar nanoparticles for therapeutic and diagnostic applications

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.LB-190-LB-190

2016

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Alkoxide-catalyzed ring-opening of A novel homosaccharin derivative : Synthesis of potent, selective P3-LACTAM thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (24), p.3683-3688

1998

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Rational design, synthesis, and serine protease inhibitory activity of a novel P1-argininal derivative featuring a conformationally constrained P2-P3 bicyclic lactam moiety

Bioorganic & medicinal chemistry letters, 1997-02, Vol.7 (3), p.331-336

1997

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Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates

Bioorganic & medicinal chemistry letters, 1997-06, Vol.7 (12), p.1543-1548

1997

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New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction

Organic letters, 2000-09, Vol.2 (18), p.2769-2772

2000

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A Practical and Efficient Synthetic Route to Dihydropipercide and Pipercide1

Journal of organic chemistry, 1998-09, Vol.63 (19), p.6667-6672

1998

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Atom-Economical Synthesis of the N(10)−C(17) Fragment of Cyclotheonamides via a Novel Passerini Reaction−Deprotection−Acyl Migration Strategy1

Organic letters, 2001-10, Vol.3 (21), p.3301-3304

2001

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Novel and general method for the preparation of peptidyl argininals

Tetrahedron letters, 1996-06, Vol.37 (24), p.4109-4112

1996

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Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin A via a novel Passerini reaction–deprotection–acyl migration strategy

Tetrahedron letters, 2001-09, Vol.42 (36), p.6271-6274

2001

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Thiazolides as Novel Antiviral Agents: I. Inhibition of Hepatitis B Virus Replication

Journal of medicinal chemistry, 2011-05, Vol.54 (12), p.4119-4132

2011

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Synthesis and Characterization of Micelle-Forming PEG-Poly(Amino Acid) Copolymers with Iron-Hydroxamate Cross-Linkable Blocks for Encapsulation and Release of Hydrophobic Drugs

Imaging the delivery of drug-loaded, iron-stabilized micelles

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus

Synthesis and facile end-group quantification of functionalized PEG azides

Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication

Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus Replication

IT-143, A Polymer Micelle Nanoparticle, Widens Therapeutic Window of Daunorubicin

A Tribute to Prof. Madeleine Joullie

Large-scale synthesis of α-amino acid-N-carboxyanhydrides

Large-scale synthesis of [alpha]-amino acid-N-carboxyanhydrides

Efficient construction of novel quaternary lactam dipeptide surrogates

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Abstract B22: IT-141, a stabilized polymer micelle formulation, prolongs the pharmacodynamic effect of SN-38

Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates

Abstract LB-190: IT-141 and IT-147, iron stabilized micellar nanoparticles for therapeutic and diagnostic applications

Alkoxide-catalyzed ring-opening of A novel homosaccharin derivative : Synthesis of potent, selective P3-LACTAM thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues

Rational design, synthesis, and serine protease inhibitory activity of a novel P1-argininal derivative featuring a conformationally constrained P2-P3 bicyclic lactam moiety

Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates

New synthetic technology for efficient construction of alpha-hydroxy-beta-amino amides via the Passerini reaction

A Practical and Efficient Synthetic Route to Dihydropipercide and Pipercide1

Atom-Economical Synthesis of the N(10)−C(17) Fragment of Cyclotheonamides via a Novel Passerini Reaction−Deprotection−Acyl Migration Strategy1

Novel and general method for the preparation of peptidyl argininals

Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin A via a novel Passerini reaction–deprotection–acyl migration strategy

Thiazolides as Novel Antiviral Agents: I. Inhibition of Hepatitis B Virus Replication

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