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Drug discovery approaches targeting the PI3K Akt pathway in cancer

Oncogene, 2008-09, Vol.27 (41), p.5511-5526

2008

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Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

Leukemia, 2017-06, Vol.31 (6), p.1269-1277

2017

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Integrated Genomic Profiling of Endometrial Carcinoma Associates Aggressive Tumors with Indicators of PI3 Kinase Activation

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (12), p.4834-4839

2009

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TERT promoter mutations and monoallelic activation of TERT in cancer

Oncogenesis (New York, NY), 2015-12, Vol.4 (12), p.e176-e176

2015

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Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

Molecular and Cellular Biology, 2000-12, Vol.20 (23), p.8969-8982

2000

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Loss of PTEN expression in paraffin-embedded primary prostate Cancer correlates with high Gleason score and advanced stage

Cancer research (Chicago, Ill.), 1999-09, Vol.59 (17), p.4291-4296

1999

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Role of the retinoblastoma protein in the pathogenesis of human cancer

Journal of clinical oncology, 1997-11, Vol.15 (11), p.3301-3312

1997

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Targeted Cancer Therapies in the Twenty-First Century: Lessons From Imatinib

Clinical pharmacology and therapeutics, 2010-05, Vol.87 (5), p.543-552

2010

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Somatic mutations are present in all members of the AKT family in endometrial carcinoma

British journal of cancer, 2009-10, Vol.101 (7), p.1218-1219

2009

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Akt-regulated pathways in prostate cancer

Oncogene, 2005-11, Vol.24 (50), p.7465-7474

2005

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Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

Molecular and Cellular Biology, 1996-12, Vol.16 (12), p.6623-6633

1996

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Molecular characterization of the tumor microenvironment in breast cancer

Cancer cell, 2004-07, Vol.6 (1), p.17-32

2004

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Nature medicine, 2004-06, Vol.10 (6), p.594-601

2004

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A Potent Transrepression Domain in the Retinoblastoma Protein Induces a Cell Cycle Arrest when Bound to E2F Sites

Proceedings of the National Academy of Sciences - PNAS, 1995-12, Vol.92 (25), p.11544-11548

1995

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Gene expression correlates of clinical prostate cancer behavior

Cancer cell, 2002-03, Vol.1 (2), p.203-209

2002

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Cancer cell, 2003-08, Vol.4 (2), p.147-158

2003

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High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

Cancer cell, 2004-09, Vol.6 (3), p.263-274

2004

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An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays

Cancer research (Chicago, Ill.), 2004-05, Vol.64 (9), p.3060-3071

2004

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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR

Cancer cell, 2002-07, Vol.2 (1), p.81-91

2002

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Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle

Molecular and Cellular Biology, 2000-12, Vol.20 (23), p.8889-8902

2000

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A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication

Proceedings of the National Academy of Sciences - PNAS, 1996-08, Vol.93 (17), p.8962-8967

1996

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Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

Molecular and Cellular Biology, 2000-07, Vol.20 (14), p.5010-5018

2000

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

Cancer cell, 2003-12, Vol.4 (6), p.463-476

2003

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Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

Cell, 1992-07, Vol.70 (2), p.351-364

1992

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Drug discovery approaches targeting the PI3K Akt pathway in cancer

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

Integrated Genomic Profiling of Endometrial Carcinoma Associates Aggressive Tumors with Indicators of PI3 Kinase Activation

TERT promoter mutations and monoallelic activation of TERT in cancer

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

Loss of PTEN expression in paraffin-embedded primary prostate Cancer correlates with high Gleason score and advanced stage

Role of the retinoblastoma protein in the pathogenesis of human cancer

Targeted Cancer Therapies in the Twenty-First Century: Lessons From Imatinib

Somatic mutations are present in all members of the AKT family in endometrial carcinoma

Akt-regulated pathways in prostate cancer

Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Molecular characterization of the tumor microenvironment in breast cancer

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

A Potent Transrepression Domain in the Retinoblastoma Protein Induces a Cell Cycle Arrest when Bound to E2F Sites

Gene expression correlates of clinical prostate cancer behavior

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR

Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle

A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

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