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The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship

PloS one, 2020-11, Vol.15 (11), p.e0241552-e0241552

2020

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Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (37), p.15950-15955

2009

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On the horizon—the value and promise of the global pipeline of Alzheimer's disease therapeutics

Alzheimer's & dementia : translational research & clinical interventions, 2020, Vol.6 (1), p.e12009-n/a

2020

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Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1296-1304

2005

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LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (47), p.17967-17972

2006

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Comprehensive Real-World Assessment of Marketed Medications to Guide Parkinson’s Drug Discovery

Clinical drug investigation, 2019-11, Vol.39 (11), p.1067-1075

2019

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Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin

The Journal of pharmacology and experimental therapeutics, 2002-12, Vol.303 (3), p.1052-1060

2002

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The familial hemiplegic migraine mutation R192q reduces G-protein-mediated inhibition of p/q-type (Cav2.1) calcium channels expressed in human embryonic kidney cells

The Journal of physiology, 2003-01, Vol.546 (2), p.337-347

2003

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Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: Implications for regulatory activity within the hypothalamic-pituitary-adrenal axis

Journal of comparative neurology (1911), 2004-06, Vol.474 (1), p.24-42

2004

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Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein

Molecular neurodegeneration, 2008-03, Vol.3 (1), p.5-5, Article 5

2008

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Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.4057-4061

2007

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Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases

The Journal of pharmacology and experimental therapeutics, 2005-05, Vol.313 (2), p.594-603

2005

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Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications

Alzheimer's & dementia : translational research & clinical interventions, 2019, Vol.5 (1), p.862-870

2019

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Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists

ACS chemical neuroscience, 2011-07, Vol.2 (7), p.352-362

2011

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A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

Molecular brain, 2010-07, Vol.3 (1), p.21-21

2010

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Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

The Journal of neuroscience, 2001-07, Vol.21 (13), p.4691-4698

2001

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Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro

Neuropharmacology, 2001-05, Vol.40 (6), p.806-817

2001

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Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation

Neurochemical research, 2010, Vol.35 (1), p.130-142

2010

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Reduced long-term potentiation in hippocampal slices prepared using sucrose-based artificial cerebrospinal fluid

Journal of neuroscience methods, 2000-07, Vol.100 (1), p.117-122

2000

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Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system : Selective antagonism by L-741,626 and L-745,870 respectively

Neuropharmacology, 1998-08, Vol.37 (8), p.983-987

1998

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Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3642-3657

2004

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Increased nuclear factor‐erythroid 2 p45‐related factor 2 activity protects SH‐SY5Y cells against oxidative damage

Journal of neurochemistry, 2005-10, Vol.95 (2), p.406-417

2005

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Beyond amyloid: the next generation of Alzheimer's disease therapeutics

Molecular interventions, 2007-10, Vol.7 (5), p.261-270

2007

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Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor

British journal of pharmacology, 2005-11, Vol.146 (5), p.702-711

2005

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Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons

The Journal of biological chemistry, 1995-06, Vol.270 (23), p.13706-13710

1995

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The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship

Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

On the horizon—the value and promise of the global pipeline of Alzheimer's disease therapeutics

Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons

LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease

Comprehensive Real-World Assessment of Marketed Medications to Guide Parkinson’s Drug Discovery

Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin

The familial hemiplegic migraine mutation R192q reduces G-protein-mediated inhibition of p/q-type (Cav2.1) calcium channels expressed in human embryonic kidney cells

Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: Implications for regulatory activity within the hypothalamic-pituitary-adrenal axis

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases

Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications

Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists

A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1

Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro

Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation

Reduced long-term potentiation in hippocampal slices prepared using sucrose-based artificial cerebrospinal fluid

Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system : Selective antagonism by L-741,626 and L-745,870 respectively

Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site

Increased nuclear factor‐erythroid 2 p45‐related factor 2 activity protects SH‐SY5Y cells against oxidative damage

Beyond amyloid: the next generation of Alzheimer's disease therapeutics

Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor

Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons

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