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Proteolysis‐targeting chimeras in drug development: A safety perspective

British journal of pharmacology, 2020-04, Vol.177 (8), p.1709-1718

2020

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Detailed dust modelling in the L-Galaxies semi-analytic model of galaxy formation

Monthly notices of the Royal Astronomical Society, 2019-11, Vol.489 (3), p.4072-4089

2019

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Label-free whole-cell assays: expanding the scope of GPCR screening

Drug discovery today, 2010-09, Vol.15 (17), p.704-716

2010

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Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

Toxicology letters, 2013-05, Vol.219 (1), p.49-58

2013

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Galaxy formation in the Planck cosmology – III. The high-redshift universe

Monthly notices of the Royal Astronomical Society, 2015-08, Vol.451 (3), p.2692-2702

2015

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Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems

Lab on a chip, 2020-04, Vol.20 (7), p.1177-1190

2020

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An impedance-based cellular assay using human iPSC-derived cardiomyocytes to quantify modulators of cardiac contractility

Toxicological sciences, 2014-12, Vol.142 (2), p.331-338

2014

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Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

Toxicological sciences, 2017-07, Vol.158 (1), p.213-226

2017

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Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs

Toxicology in vitro, 2020-10, Vol.68, p.104928, Article 104928

2020

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Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

Cardiovascular toxicology, 2015-04, Vol.15 (2), p.127-139

2015

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Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea

Toxicological sciences, 2019-03, Vol.168 (1), p.3-17

2019

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Evaluating Cellular Impedance Assays for Detection of GPCR Pleiotropic Signaling and Functional Selectivity

Journal of biomolecular screening, 2009-03, Vol.14 (3), p.246-255

2009

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Toward β‑Secretase‑1 Inhibitors with Improved Isoform Selectivity

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3491-3502

2018

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Development of a Plate-Based Optical Biosensor Fragment Screening Methodology to Identify Phosphodiesterase 10A Inhibitors

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3228-3234

2013

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Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity

Toxicological sciences, 2013-10, Vol.135 (2), p.402-413

2013

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Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications

Assay and drug development technologies, 2012-12, Vol.10 (6), p.525-532

2012

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Comparing label-free biosensors for pharmacological screening with cell-based functional assays

Assay and drug development technologies, 2010-04, Vol.8 (2), p.219-227

2010

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Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (1), p.197-202

2016

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Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs

Journal of biomolecular screening, 2007-04, Vol.12 (3), p.312-319

2007

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NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis

iScience, 2023-03, Vol.26 (3), p.106163-106163, Article 106163

2023

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Mechanism of Inhibition of Fatty Acid Amide Hydrolase by Sulfonamide-Containing Benzothiazoles: Long Residence Time Derived from Increased Kinetic Barrier and Not Exclusively from Thermodynamic Potency

Biochemistry (Easton), 2011-08, Vol.50 (32), p.6867-6878

2011

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.31499-31505

2002

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Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.930-935

2015

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Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition

Molecular pharmacology, 2007-03, Vol.71 (3), p.902-911

2007

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Proteolysis‐targeting chimeras in drug development: A safety perspective

Detailed dust modelling in the L-Galaxies semi-analytic model of galaxy formation

Label-free whole-cell assays: expanding the scope of GPCR screening

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

Galaxy formation in the Planck cosmology – III. The high-redshift universe

Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems

An impedance-based cellular assay using human iPSC-derived cardiomyocytes to quantify modulators of cardiac contractility

Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models

Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea

Evaluating Cellular Impedance Assays for Detection of GPCR Pleiotropic Signaling and Functional Selectivity

Toward β‑Secretase‑1 Inhibitors with Improved Isoform Selectivity

Development of a Plate-Based Optical Biosensor Fragment Screening Methodology to Identify Phosphodiesterase 10A Inhibitors

Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity

Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications

Comparing label-free biosensors for pharmacological screening with cell-based functional assays

Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors

Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs

NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis

Mechanism of Inhibition of Fatty Acid Amide Hydrolase by Sulfonamide-Containing Benzothiazoles: Long Residence Time Derived from Increased Kinetic Barrier and Not Exclusively from Thermodynamic Potency

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens

Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition

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