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Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Nature, 2004-05, Vol.429 (6988), p.188-193

2004

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Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

PloS one, 2017-07, Vol.12 (7), p.e0180190-e0180190

2017

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Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

The Journal of biological chemistry, 1999-06, Vol.274 (25), p.17406-17409

1999

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Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

Molecular pharmacology, 2008-12, Vol.74 (6), p.1599-1609

2008

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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1

Molecular and cellular endocrinology, 2013-04, Vol.369 (1-2), p.119-129

2013

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STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells

Cancer research (Chicago, Ill.), 2011-09, Vol.71 (17), p.5818-5826

2011

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Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

The Journal of experimental medicine, 2000-04, Vol.191 (7), p.1233-1240

2000

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The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.493-498

2010

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Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes

The Journal of clinical investigation, 2004-05, Vol.113 (10), p.1473-1481

2004

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Mutational analysis of G-protein coupled receptor – FFA2

Biochemical and biophysical research communications, 2011-02, Vol.405 (1), p.122-127

2011

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Allosteric rescuing of loss-of-function FFAR2 mutations

FEBS letters, 2010-10, Vol.584 (19), p.4208-4214

2010

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Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling

The Journal of biological chemistry, 1999-04, Vol.274 (15), p.10203-10212

1999

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TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase

The Journal of biological chemistry, 1998-03, Vol.273 (10), p.5916-5922

1998

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High throughput screening for orphan and liganded GPCRs

Combinatorial chemistry & high throughput screening, 2008-03, Vol.11 (3), p.195

2008

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Activation and Inhibition of Assay-Ready TRPA1 and TRPV Cells: An Automated Patch Clamp Study

Biophysical journal, 2021-02, Vol.120 (3), p.336a-336a

2021

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Requirement of FADD for Tumor Necrosis Factor-induced Activation of Acid Sphingomyelinase

The Journal of biological chemistry, 1999-02, Vol.274 (9), p.5267-5270

1999

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Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes

The Journal of clinical investigation, 2004-05, Vol.113 (10), p.1473-1481

2004

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Cutting Edge: Inflammatory Signaling by Borrelia burgdorferi Lipoproteins Is Mediated by Toll-Like Receptor 2

The Journal of immunology (1950), 1999-09, Vol.163 (5), p.2382-2386

1999

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Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs

Toxicological sciences, 2015-06, Vol.145 (2), p.283-295

2015

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Cathepsin D targeted by acid sphingomyelinase-derived ceramide

The EMBO journal, 1999-10, Vol.18 (19), p.5252-5263

1999

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High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases

Journal of biomolecular screening, 2012-01, Vol.17 (1), p.27-38

2012

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Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (3), p.1037-1041

2008

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Abstract 253: Identification of STK33 kinase inhibitors for the validation of a synthetic lethal relationship between STK33 and mutant KRAS

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.253-253

2011

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SS5-6 Oxysterols are ligands for the orphan nucler receptor RORγt, a key regulator of Th17 cell development

Cytokine (Philadelphia, Pa.), 2010-10, Vol.52 (1-2), p.45-45

2010

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Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor

Journal of leukocyte biology, 1998-06, Vol.63 (6), p.678-682

1998

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Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1

STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes

Mutational analysis of G-protein coupled receptor – FFA2

Allosteric rescuing of loss-of-function FFAR2 mutations

Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling

TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase

High throughput screening for orphan and liganded GPCRs

Activation and Inhibition of Assay-Ready TRPA1 and TRPV Cells: An Automated Patch Clamp Study

Requirement of FADD for Tumor Necrosis Factor-induced Activation of Acid Sphingomyelinase

Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes

Cutting Edge: Inflammatory Signaling by Borrelia burgdorferi Lipoproteins Is Mediated by Toll-Like Receptor 2

Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases

Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

Abstract 253: Identification of STK33 kinase inhibitors for the validation of a synthetic lethal relationship between STK33 and mutant KRAS

SS5-6 Oxysterols are ligands for the orphan nucler receptor RORγt, a key regulator of Th17 cell development

Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor

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