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Mixed‐effects models and the drug titration paradox

CPT: pharmacometrics and systems pharmacology, 2023-04, Vol.12 (4), p.429-429

2023

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Dose matters: optimized dosing is part of optimized care

Minerva anestesiologica, 2018-04, Vol.84 (4)

2018

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Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery

Journal of the American College of Cardiology, 2021-11, Vol.78 (18), p.1753-1764

2021

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The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data

Clinical pharmacology and therapeutics, 2021-08, Vol.110 (2), p.401-408

2021

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Pharmacokinetic and Pharmacodynamic Concepts Underpinning Total Intravenous Anesthesia

Journal of cardiothoracic and vascular anesthesia, 2015-06, Vol.29, p.S7-S10

Schnider, Thomas W., MD

2015

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Variability of predicted propofol concentrations and measured sevoflurane concentrations during general anaesthesia: a single-centre retrospective cohort study

British journal of anaesthesia : BJA, 2023-10, Vol.131 (4), p.687-693

2023

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Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics

Anesthesiology (Philadelphia), 2003-08, Vol.99 (2), p.324-333

2003

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Analgesic efficacy of systemic lidocaine using lean body mass based dosing regime versus placebo in bariatric surgery: a prospective, randomised, double-blind, placebo-controlled, single-centre study

British journal of anaesthesia : BJA, 2023-07, Vol.131 (1), p.122-129

2023

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Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology

Anesthesiology (Philadelphia), 2024-01, Vol.140 (1), p.157-163

2024

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Drug Titration Paradox: Reply

Anesthesiology (Philadelphia), 2024-08, Vol.141 (2), p.412-413

2024

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Steady-state trumps accuracy: target-controlled infusion as a gain switch

British journal of anaesthesia : BJA, 2024-10, Vol.133 (4), p.726-729

2024

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The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers

Anesthesiology (Philadelphia), 1998-05, Vol.88 (5), p.1170-1182

1998

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Beware the drug titration paradox. Comment on Br J Anaesth 2021; 127: 704–12

British journal of anaesthesia : BJA, 2022-06, Vol.128 (6), p.e335-e337

2022

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Relationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia

Anesthesia and analgesia, 2021-03, Vol.132 (3), p.735-742

2021

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“Awake” or “Sedated”: Safe Flexible Bronchoscopic Intubation of the Difficult Airway

Anesthesia and analgesia, 2017-03, Vol.124 (3), p.996-997

2017

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Pro-Con Debate: Should All General Anesthesia Be Done Using Target-Controlled Propofol Infusion Guided by Objective Monitoring of Depth of Anesthesia?

Anesthesia and analgesia, 2023-09, Vol.137 (3), p.565-575

2023

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In Vitro Inhibition of Factor XIII Retards Clot Formation, Reduces Clot Firmness, and Increases Fibrinolytic Effects in Whole Blood

Anesthesia and analgesia, 2009-10, Vol.109 (4), p.1023-1028

2009

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The drug titration paradox: more drug does not correlate with more effect in individual clinical data

British journal of anaesthesia : BJA, 2022-12, Vol.129 (6), p.861-867

2022

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Impact of staff education on the burden of hypotension during major noncardiac surgery

British journal of anaesthesia : BJA, 2024-09, Vol.133 (3), p.671-674

2024

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Modulation of Remifentanil-Induced Analgesia, Hyperalgesia, and Tolerance by Small-Dose Ketamine in Humans

Anesthesia and analgesia, 2003-03, Vol.96 (3), p.726-732

2003

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Clinical validation of pharmacokinetic and pharmacodynamic models for propofol infusion. Comment on Br J Anaesth 2021; 126: 386–94

British journal of anaesthesia : BJA, 2021-05, Vol.126 (5), p.e172-e174

2021

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Target-Controlled Infusion: A Mature Technology

Anesthesia and analgesia, 2016-01, Vol.122 (1), p.70-78

2016

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Moving from dose to concentration: as easy as TCI

British journal of anaesthesia : BJA, 2020-12, Vol.125 (6), p.847-849

2020

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The History of Target-Controlled Infusion

Anesthesia and analgesia, 2016-01, Vol.122 (1), p.56-69

2016

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Patient Factors Affecting Bispectral Index During Total Intravenous Anesthesia With Target-Controlled Infusion

Anesthesia and analgesia, 2020-09, Vol.131 (3), p.e160-e160

2020

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Mixed‐effects models and the drug titration paradox

Dose matters: optimized dosing is part of optimized care

Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery

The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data

Pharmacokinetic and Pharmacodynamic Concepts Underpinning Total Intravenous Anesthesia

Variability of predicted propofol concentrations and measured sevoflurane concentrations during general anaesthesia: a single-centre retrospective cohort study

Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics

Analgesic efficacy of systemic lidocaine using lean body mass based dosing regime versus placebo in bariatric surgery: a prospective, randomised, double-blind, placebo-controlled, single-centre study

Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology

Drug Titration Paradox: Reply

Steady-state trumps accuracy: target-controlled infusion as a gain switch

The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers

Beware the drug titration paradox. Comment on Br J Anaesth 2021; 127: 704–12

Relationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia

“Awake” or “Sedated”: Safe Flexible Bronchoscopic Intubation of the Difficult Airway

Pro-Con Debate: Should All General Anesthesia Be Done Using Target-Controlled Propofol Infusion Guided by Objective Monitoring of Depth of Anesthesia?

In Vitro Inhibition of Factor XIII Retards Clot Formation, Reduces Clot Firmness, and Increases Fibrinolytic Effects in Whole Blood

The drug titration paradox: more drug does not correlate with more effect in individual clinical data

Impact of staff education on the burden of hypotension during major noncardiac surgery

Modulation of Remifentanil-Induced Analgesia, Hyperalgesia, and Tolerance by Small-Dose Ketamine in Humans

Clinical validation of pharmacokinetic and pharmacodynamic models for propofol infusion. Comment on Br J Anaesth 2021; 126: 386–94

Target-Controlled Infusion: A Mature Technology

Moving from dose to concentration: as easy as TCI

The History of Target-Controlled Infusion

Patient Factors Affecting Bispectral Index During Total Intravenous Anesthesia With Target-Controlled Infusion

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