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Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia

Angewandte Chemie International Edition, 2005-01, Vol.44 (5), p.690-715

2005

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Subcellular localization of adenylate kinases in Plasmodium falciparum

FEBS letters, 2012-09, Vol.586 (19), p.3037-3043

2012

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Glutathione Reductase-Catalyzed Cascade of Redox Reactions To Bioactivate Potent Antimalarial 1,4-Naphthoquinones – A New Strategy to Combat Malarial Parasites

Journal of the American Chemical Society, 2011-08, Vol.133 (30), p.11557-11571

2011

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Lest we forget you — methylene blue

Neurobiology of aging, 2011-12, Vol.32 (12), p.2325.e7-2325.e16

2011

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Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial

PloS one, 2009-05, Vol.4 (5), p.e5318-e5318

2009

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Interactions of Methylene Blue with Human Disulfide Reductases and Their Orthologues from Plasmodium falciparum

Antimicrobial Agents and Chemotherapy, 2008-01, Vol.52 (1), p.183-191

2008

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5-Substituted Tetrazoles as Bioisosteres of Carboxylic Acids. Bioisosterism and Mechanistic Studies on Glutathione Reductase Inhibitors as Antimalarials

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5972-5983

2004

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Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso

PloS one, 2008-02, Vol.3 (2), p.e1630

2008

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Efficacy of methylene blue monotherapy in semi-immune adults with uncomplicated falciparum malaria: a controlled trial in Burkina Faso

Tropical medicine & international health, 2010-06, Vol.15 (6), p.713-717

2010

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In Vitro Assessment of Methylene Blue on Chloroquine-Sensitive and -Resistant Plasmodium falciparum Strains Reveals Synergistic Action with Artemisinins

Antimicrobial Agents and Chemotherapy, 2005-11, Vol.49 (11), p.4592-4597

2005

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Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs

Pharmacoepidemiology and drug safety, 2013-04, Vol.22 (4), p.376-385

2013

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Active Sites of Thioredoxin Reductases: Why Selenoproteins?

Proceedings of the National Academy of Sciences - PNAS, 2003-10, Vol.100 (22), p.12618-12623

2003

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Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study

PloS one, 2009-10, Vol.4 (10), p.e7303

2009

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Molecular basis of glutathione reductase deficiency in human blood cells

Blood, 2007-04, Vol.109 (8), p.3560-3566

2007

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Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite

The Journal of biological chemistry, 2002-01, Vol.277 (4), p.2779-2784

2002

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Human Thioredoxin Reductase Is Efficiently Inhibited by (2,2‘:6‘,2‘ ‘-Terpyridine)platinum(II) Complexes. Possible Implications for a Novel Antitumor Strategy

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2784-2792

2001

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Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

Malaria journal, 2006-10, Vol.5 (1), p.84-84, Article 84

2006

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Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite

PloS one, 2008-06, Vol.3 (6), p.e2474-e2474

2008

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X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium falciparum

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (24), p.13821-13826

2003

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Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum

Antimicrobial Agents and Chemotherapy, 2006-09, Vol.50 (9), p.3132-3141

2006

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Human placenta thioredoxin reductase: Preparation and inhibitor studies

Methods in Enzymology, 2002, Vol.347, p.382-394

2002

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The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (8), p.3621-3626

1997

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Thioredoxin reductase as a pathophysiological factor and drug target

European journal of biochemistry, 2000-10, Vol.267 (20), p.6118-6125

2000

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Efficacy and Safety of Triple Combination Therapy With Artesunate-Amodiaquine-Methylene Blue for Falciparum Malaria in Children: A Randomized Controlled Trial in Burkina Faso

The Journal of infectious diseases, 2015-03, Vol.211 (5), p.689-697

2015

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The Mechanism of High Mr Thioredoxin Reductase from Drosophila melanogaster

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33020-33028

2003

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Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia

Subcellular localization of adenylate kinases in Plasmodium falciparum

Glutathione Reductase-Catalyzed Cascade of Redox Reactions To Bioactivate Potent Antimalarial 1,4-Naphthoquinones – A New Strategy to Combat Malarial Parasites

Lest we forget you — methylene blue

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial

Interactions of Methylene Blue with Human Disulfide Reductases and Their Orthologues from Plasmodium falciparum

5-Substituted Tetrazoles as Bioisosteres of Carboxylic Acids. Bioisosterism and Mechanistic Studies on Glutathione Reductase Inhibitors as Antimalarials

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso

Efficacy of methylene blue monotherapy in semi-immune adults with uncomplicated falciparum malaria: a controlled trial in Burkina Faso

In Vitro Assessment of Methylene Blue on Chloroquine-Sensitive and -Resistant Plasmodium falciparum Strains Reveals Synergistic Action with Artemisinins

Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs

Active Sites of Thioredoxin Reductases: Why Selenoproteins?

Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study

Molecular basis of glutathione reductase deficiency in human blood cells

Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite

Human Thioredoxin Reductase Is Efficiently Inhibited by (2,2‘:6‘,2‘ ‘-Terpyridine)platinum(II) Complexes. Possible Implications for a Novel Antitumor Strategy

Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite

X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium falciparum

Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum

Human placenta thioredoxin reductase: Preparation and inhibitor studies

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

Thioredoxin reductase as a pathophysiological factor and drug target

Efficacy and Safety of Triple Combination Therapy With Artesunate-Amodiaquine-Methylene Blue for Falciparum Malaria in Children: A Randomized Controlled Trial in Burkina Faso

The Mechanism of High Mr Thioredoxin Reductase from Drosophila melanogaster

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