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A role for the C2 domain of factor VIII in binding to von Willebrand factor

The Journal of biological chemistry, 1994-04, Vol.269 (15), p.11601-11605

1994

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Transgenic pigs produce functional human factor VIII in milk

Nature biotechnology, 1997-10, Vol.15 (10), p.971-975

1997

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Epitope Specificity and Inactivation Mechanisms of Factor VIII Inhibitor Antibodies

Vox sanguinis, 1999-01, Vol.77 (Suppl 1), p.17-20

Scandella, Dorothea

1999

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Properties of Anti-Factor VIII Inhibitor Antibodies in Hemophilia A Patients

Seminars in thrombosis and hemostasis, 2000, Vol.26 (2), p.137-142

Scandella, Dorothea H.

2000

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Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site

Blood, 1995-09, Vol.86 (5), p.1811-1819

1995

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A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine

Thrombosis and haemostasis, 1993, Vol.69 (3), p.240-246

1993

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Inhibitors in German hemophilia A patients treated with a double virus inactivated factor VIII concentrate bind to the C2 domain of FVIII light chain

Thrombosis and haemostasis, 1999-01, Vol.81 (1), p.39-44

1999

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In Hemophilia A and Autoantibody Inhibitor Patients: The Factor VIII A2 Domain and Light Chain Are Most Immunogenic

Thrombosis research, 2001-03, Vol.101 (5), p.377-385

2001

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The Acidic Region of the Factor VIII Light Chain and the C2 Domain Together Form the High Affinity Binding Site for von Willebrand Factor

The Journal of biological chemistry, 1997-07, Vol.272 (29), p.18007-18014

1997

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Management of sanitary and phytosanitary risks in the apple value chain: the Sustain’Apple project

Acta horticulturae, 2019-01 (1242), p.295-302

2019

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Epitope Mapping of Human Factor VIII Inhibitor Antibodies by Deletion Analysis of Factor VIII Fragments Expressed in Escherichia coli

Proceedings of the National Academy of Sciences - PNAS, 1988-08, Vol.85 (16), p.6152-6156

1988

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New Characteristics of Anti-Factor VIII Inhibitor Antibody Epitopes and Unusual Immune Responses to Factor VIII

Seminars in thrombosis and hemostasis, 2002-06, Vol.28 (3), p.291-296

Scandella, Dorothea

2002

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Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A

Blood, 2001-05, Vol.97 (9), p.2750-2757

2001

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Factor VIII inhibitors : structure and function in autoantibody and hemophilia A patients

Seminars in hematology, 1994-04, Vol.31 (2), p.1-5

1994

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Localization of Epitopes for Human Factor VIII Inhibitor Antibodies by Immunoblotting and Antibody Neutralization

Blood, 1989-10, Vol.74 (5), p.1618-1626

1989

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Detection of all anti-factor VIII antibodies in haemophilia A patients by the Bethesda assay and a more sensitive immunoprecipitation assay

Haemophilia : the official journal of the World Federation of Hemophilia, 2001-01, Vol.7 (1), p.26-32

2001

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Characterization of antibodies to factor VIII in hemophilia A patients treated by immune tolerance therapy

Haematologica (Roma), 2000-10, Vol.85 (10 Suppl), p.86

2000

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Elimination of a major inhibitor epitope in factor VIII

The Journal of biological chemistry, 1994-03, Vol.269 (12), p.8639-8641

1994

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Low factor VIII recovery in haemophilia A patients without inhibitor titre is not due to the presence of anti-factor VIII antibodies undetectable by the Bethesda assay

Haemophilia : the official journal of the World Federation of Hemophilia, 2001-01, Vol.7 (1), p.13-19

2001

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Human Inhibitor Antibodies Specific for the Factor VIII A2 Domain Disrupt the Interaction between the Subunit and Factor IXa

The Journal of biological chemistry, 1999-10, Vol.274 (42), p.29826-29830

1999

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An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia A due to deletion of a large portion of the A1 domain DNA sequence

Thrombosis and haemostasis, 2000-09, Vol.84 (3), p.442-448

2000

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Identification of the binding site for activated protein C on the light chain of factors V and VIII

The Journal of biological chemistry, 1990-01, Vol.265 (3), p.1484-1489

1990

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The natural history of the immune response to exogenous factor VIII in severe haemophilia A

Haemophilia : the official journal of the World Federation of Hemophilia, 1998-07, Vol.4 (4), p.546-551

1998

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Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules

Blood, 2000-01, Vol.95 (2), p.564-568

2000

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A soluble recombinant factor VIII fragment containing the A2 domain binds to some human anti-factor VIII antibodies that are not detected by immunoblotting

Thrombosis and haemostasis, 1992-06, Vol.67 (6), p.665-671

1992

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A role for the C2 domain of factor VIII in binding to von Willebrand factor

Transgenic pigs produce functional human factor VIII in milk

Epitope Specificity and Inactivation Mechanisms of Factor VIII Inhibitor Antibodies

Properties of Anti-Factor VIII Inhibitor Antibodies in Hemophilia A Patients

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site

A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine

Inhibitors in German hemophilia A patients treated with a double virus inactivated factor VIII concentrate bind to the C2 domain of FVIII light chain

In Hemophilia A and Autoantibody Inhibitor Patients: The Factor VIII A2 Domain and Light Chain Are Most Immunogenic

The Acidic Region of the Factor VIII Light Chain and the C2 Domain Together Form the High Affinity Binding Site for von Willebrand Factor

Management of sanitary and phytosanitary risks in the apple value chain: the Sustain’Apple project

Epitope Mapping of Human Factor VIII Inhibitor Antibodies by Deletion Analysis of Factor VIII Fragments Expressed in Escherichia coli

New Characteristics of Anti-Factor VIII Inhibitor Antibody Epitopes and Unusual Immune Responses to Factor VIII

Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A

Factor VIII inhibitors : structure and function in autoantibody and hemophilia A patients

Localization of Epitopes for Human Factor VIII Inhibitor Antibodies by Immunoblotting and Antibody Neutralization

Detection of all anti-factor VIII antibodies in haemophilia A patients by the Bethesda assay and a more sensitive immunoprecipitation assay

Characterization of antibodies to factor VIII in hemophilia A patients treated by immune tolerance therapy

Elimination of a major inhibitor epitope in factor VIII

Low factor VIII recovery in haemophilia A patients without inhibitor titre is not due to the presence of anti-factor VIII antibodies undetectable by the Bethesda assay

Human Inhibitor Antibodies Specific for the Factor VIII A2 Domain Disrupt the Interaction between the Subunit and Factor IXa

An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia A due to deletion of a large portion of the A1 domain DNA sequence

Identification of the binding site for activated protein C on the light chain of factors V and VIII

The natural history of the immune response to exogenous factor VIII in severe haemophilia A

Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules

A soluble recombinant factor VIII fragment containing the A2 domain binds to some human anti-factor VIII antibodies that are not detected by immunoblotting

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