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Identification of potential small molecule binding pockets on Rho family GTPases

PloS one, 2012-07, Vol.7 (7), p.e40809

2012

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Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth

Molecular cancer therapeutics, 2008-08, Vol.7 (8), p.2308-2318

2008

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Surface Expression and CEA Binding of hnRNP M4 Protein in HT29 Colon Cancer Cells

Anticancer research, 2005-01, Vol.25 (1A), p.23-31

2005

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The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth

The Journal of biological chemistry, 2014-06, Vol.289 (25), p.17689-17698

2014

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Abstract 4101: Thrombin stimulates glioblastoma cell proliferation, adhesion and in vivo tumor growth through Rap1 activation

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.4101-4101

2013

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Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells

Carcinogenesis (New York), 2005-07, Vol.26 (7), p.1182-1195

2005

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Thrombin stimulated glioblastoma cell adhesion is mediated by Rap1 and integrin activation

The FASEB journal, 2012-04, Vol.26 (S1)

2012

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RhoA and Rap1 mediate GPCR crosstalk to integrins and cell growth

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Thrombin stimulated glioblastoma cell proliferation is mediated by RhoA and phospholipase D dependent Rap1 activation

The FASEB journal, 2011-04, Vol.25 (S1), p.1009.7-1009.7

2011

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Inhibition of the phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy

Cancer research (Chicago, Ill.), 2005-09, Vol.65 (18), p.8423-8432

2005

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Thrombin mediated PAR1 stimulation results in sustained activation of Rap1 and downstream responses in human 1321N1 astroglioma cells

The FASEB journal, 2010-04, Vol.24 (S1), p.769.16-769.16

2010

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Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies

Current oncology reports, 2009-03, Vol.11 (2), p.117-124

2009

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Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation

Cellular signalling, 2011-11, Vol.23 (11), p.1806-1815

2011

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Phosphorylation of Y372 is critical for ligand mediated Jak2 tyrosine kinase activation

The FASEB journal, 2011-04, Vol.25, p.558.1-558.1

2011

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Tyrosine 972 is Critical for Jak2 Tyrosine Kinase Function

The FASEB journal, 2007, Vol.21 (6), p.A1211-A1211

2007

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Identification and Characterization of a Novel Jak2 Tyrosine Kinase Inhibitor

The FASEB journal, 2007, Vol.21 (6), p.A793-A793

2007

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Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3598-3601

2009

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Identification and Characterization of a Novel Jak2 Tyrosine Kinase Inhibitor

Blood, 2006-11, Vol.108 (11), p.3604-3604

2006

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The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor

Cellular signalling, 2007-03, Vol.19 (3), p.600-609

2007

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Identification and Characterization of a Series of Novel Jak2 Small Molecule Inhibitor Compounds

Blood, 2007-11, Vol.110 (11), p.539-539

2007

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Characterization of novel Jak2 tyrosine kinase small molecule inhibitors and sites of Jak2 phospho-regulation

Sayyah, Jacqueline

2009

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The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT 1 receptor

Cellular signalling, 2007, Vol.19 (3), p.600-609

2007

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Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells

Carcinogenesis (New York), 2005-07, Vol.26 (7), p.1182

2005

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Identification of potential small molecule binding pockets on Rho family GTPases

Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth

Surface Expression and CEA Binding of hnRNP M4 Protein in HT29 Colon Cancer Cells

The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth

Abstract 4101: Thrombin stimulates glioblastoma cell proliferation, adhesion and in vivo tumor growth through Rap1 activation

Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells

Thrombin stimulated glioblastoma cell adhesion is mediated by Rap1 and integrin activation

RhoA and Rap1 mediate GPCR crosstalk to integrins and cell growth

Thrombin stimulated glioblastoma cell proliferation is mediated by RhoA and phospholipase D dependent Rap1 activation

Inhibition of the phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy

Thrombin mediated PAR1 stimulation results in sustained activation of Rap1 and downstream responses in human 1321N1 astroglioma cells

Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies

Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation

Phosphorylation of Y372 is critical for ligand mediated Jak2 tyrosine kinase activation

Tyrosine 972 is Critical for Jak2 Tyrosine Kinase Function

Identification and Characterization of a Novel Jak2 Tyrosine Kinase Inhibitor

Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening

Identification and Characterization of a Novel Jak2 Tyrosine Kinase Inhibitor

The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor

Identification and Characterization of a Series of Novel Jak2 Small Molecule Inhibitor Compounds

Characterization of novel Jak2 tyrosine kinase small molecule inhibitors and sites of Jak2 phospho-regulation

The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT 1 receptor

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells

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