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Metabolism, Excretion, and Mass Balance of the HIV-1 Integrase Inhibitor Dolutegravir in Humans

Antimicrobial Agents and Chemotherapy, 2013-08, Vol.57 (8), p.3536-3546

2013

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In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor

Drug metabolism and disposition, 2013-02, Vol.41 (2), p.353

2013

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Effect of Prednisone on the Pharmacokinetics of the Integrase Inhibitor Dolutegravir

Antimicrobial Agents and Chemotherapy, 2013-09, Vol.57 (9), p.4394-4397

2013

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Pharmacokinetics of Single-Dose Dolutegravir in HIV-Seronegative Subjects With Moderate Hepatic Impairment Compared to Healthy Matched Controls

Clinical pharmacology in drug development, 2013-10, Vol.2 (4), p.342-348

2013

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A sensitive HPLC–MS/MS method for the determination of dolutegravir in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014-01, Vol.945-946, p.225-232

2014

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Bioequivalence of a dolutegravir, abacavir, and lamivudine fixed-dose combination tablet and the effect of food

Journal of acquired immune deficiency syndromes (1999), 2014-08, Vol.66 (4), p.393

2014

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Pharmacokinetics of dolutegravir in HIV-seronegative subjects with severe renal impairment

European journal of clinical pharmacology, 2014-01, Vol.70 (1), p.29-35

2014

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Effects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir

British journal of clinical pharmacology, 2014-11, Vol.78 (5), p.1043-1049

2014

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Dolutegravir does not affect methadone pharmacokinetics in opioid-dependent, HIV-seronegative subjects

Drug and alcohol dependence, 2013-12, Vol.133 (2), p.781-784

2013

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Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir

European journal of clinical pharmacology, 2014-10, Vol.70 (10), p.1173-1179

2014

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Evaluation of the Carcinogenic Potential of Clofibrate in FVB/Tg.AC Mouse After Oral Administration—Part I

International journal of toxicology, 2005-09, Vol.24 (5), p.313-325

2005

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Evaluation of the Carcinogenic Potential of Clofibrate in the p53+ / − Mouse

International journal of toxicology, 2005-09, Vol.24 (5), p.289-299

2005

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Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats

Cancer research (Chicago, Ill.), 1994-09, Vol.54 (17), p.4710-4714

1994

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Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma

Cancer research (Chicago, Ill.), 1988-10, Vol.48 (19), p.5397-5402

1988

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Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR

Cancer research (Chicago, Ill.), 1991-08, Vol.51 (15), p.3906-3909

1991

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Application of directly coupled LC–NMR–MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83

Journal of chromatography. B, Biomedical sciences and applications, 2000-10, Vol.748 (1), p.269-279

2000

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Validation of a high-performance liquid chromatographic-mass spectrometric method for the measurement of 5-chloro-2′,3′-dideoxy-3′-fluorouridine (935U83) in human plasma

Journal of chromatography. B, Biomedical applications, 1996-11, Vol.686 (2), p.241-248

1996

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Safety and pharmacokinetics of 5-chloro-2',3'-dideoxy-3'-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults

Antimicrobial Agents and Chemotherapy, 1996-12, Vol.40 (12), p.2842-2847

1996

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Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft

Radiation research, 1992-02, Vol.129 (2), p.218

1992

Volltextzugriff (PDF)

Optimal Perfusion Rate Determined for In Situ Intestinal Absorption Studies in Rats

Journal of pharmaceutical sciences, 1981-03, Vol.70 (3), p.239-243

1981

Volltextzugriff (PDF)

Patterns of care and outcomes of patients with METAstatic soft tissue SARComa in a real-life setting: the METASARC observational study

BMC medicine, 2017-04, Vol.15 (1), p.78-78, Article 78

2017

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Sleep Problems, Comorbid Mental Disorders, and Role Functioning in the National Comorbidity Survey Replication

Biological psychiatry (1969), 2006-12, Vol.60 (12), p.1364-1371

2006

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NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes

Journal of Virology, 2011-07, Vol.85 (14), p.6963-6976

2011

Volltextzugriff (PDF)

Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status

Clinical cancer research, 2018-06, Vol.24 (11), p.2548-2558

2018

Volltextzugriff (PDF)

Multi-element isotopic analysis of hot particles from Chornobyl

Journal of hazardous materials, 2023-06, Vol.452, p.131338-131338, Article 131338

2023

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Metabolism, Excretion, and Mass Balance of the HIV-1 Integrase Inhibitor Dolutegravir in Humans

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor

Effect of Prednisone on the Pharmacokinetics of the Integrase Inhibitor Dolutegravir

Pharmacokinetics of Single-Dose Dolutegravir in HIV-Seronegative Subjects With Moderate Hepatic Impairment Compared to Healthy Matched Controls

A sensitive HPLC–MS/MS method for the determination of dolutegravir in human plasma

Bioequivalence of a dolutegravir, abacavir, and lamivudine fixed-dose combination tablet and the effect of food

Pharmacokinetics of dolutegravir in HIV-seronegative subjects with severe renal impairment

Effects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir

Dolutegravir does not affect methadone pharmacokinetics in opioid-dependent, HIV-seronegative subjects

Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir

Evaluation of the Carcinogenic Potential of Clofibrate in FVB/Tg.AC Mouse After Oral Administration—Part I

Evaluation of the Carcinogenic Potential of Clofibrate in the p53+ / − Mouse

Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats

Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma

Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR

Application of directly coupled LC–NMR–MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83

Validation of a high-performance liquid chromatographic-mass spectrometric method for the measurement of 5-chloro-2′,3′-dideoxy-3′-fluorouridine (935U83) in human plasma

Safety and pharmacokinetics of 5-chloro-2',3'-dideoxy-3'-fluorouridine (935U83) following oral administration of escalating single doses in human immunodeficiency virus-infected adults

Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft

Optimal Perfusion Rate Determined for In Situ Intestinal Absorption Studies in Rats

Patterns of care and outcomes of patients with METAstatic soft tissue SARComa in a real-life setting: the METASARC observational study

Sleep Problems, Comorbid Mental Disorders, and Role Functioning in the National Comorbidity Survey Replication

NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes

Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status

Multi-element isotopic analysis of hot particles from Chornobyl

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