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Arginine deprivation as a targeted therapy for cancer

Current pharmaceutical design, 2008-04, Vol.14 (11), p.1049

2008

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Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma

Current molecular medicine, 2010-06, Vol.10 (4), p.405

2010

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Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

Oncogene, 2016-03, Vol.35 (13), p.1632-1642

2016

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Hypersensitization of Tumor Cells to Glycolytic Inhibitors

Biochemistry (Easton), 2001-05, Vol.40 (18), p.5542-5547

2001

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2-deoxy-d-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

Cancer research (Chicago, Ill.), 2004, Vol.64 (1), p.31-34

2004

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Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells

Molecular cancer therapeutics, 2004-12, Vol.3 (12), p.1543-1549

2004

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Pegylated Arginine Deiminase Treatment of Patients With Metastatic Melanoma: Results From Phase I and II Studies

Journal of clinical oncology, 2005-10, Vol.23 (30), p.7660-7668

2005

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Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers

Molecular carcinogenesis, 2006-09, Vol.45 (9), p.701-709

2006

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Circumvention of P-GP MDR as a Function of Anthracycline Lipophilicity and Charge

Biochemistry (Easton), 1997-03, Vol.36 (9), p.2679-2685

1997

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Phase I and Pharmacokinetic Study of Triapine, a Potent Ribonucleotide Reductase Inhibitor, Administered Daily for Five Days in Patients with Advanced Solid Tumors

Clinical cancer research, 2003-09, Vol.9 (11), p.4092-4100

2003

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Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C)

Biochemical pharmacology, 2002-12, Vol.64 (12), p.1745-1751

2002

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CS-03 UTILIZING COLLAGEN AND DISCOIDIN DOMAIN RECEPTOR SIGNALING AS A NEWTHERAPEUTIC STRATEGY IN HUMAN MALIGNANT GLIOMA

Neuro-oncology (Charlottesville, Va.), 2014-11, Vol.16 (suppl 5), p.v51-v51

2014

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Phase II trial of SOM230 (pasireotide LAR) in patients with unresectable hepatocellular carcinoma

Journal of hepatocellular carcinoma, 2018-01, Vol.5, p.9-15

2018

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Determining argininosuccinate synthetase (ASS) expression in patients with melanoma treated with arginine depleting therapy

Journal of clinical oncology, 2011-05, Vol.29 (15_suppl), p.10627-10627

2011

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Role of concurrent chemoradiotherapy in organ preservation for locally advanced head and neck cancer

Journal of clinical oncology, 2009-05, Vol.27 (15_suppl), p.e17044-e17044

2009

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Phase II study of vinorelbine with low dose prednisone in the treatment of hormone-refractory metastatic prostate cancer

Oncology reports, 2003-07, Vol.10 (4), p.885

2003

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Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule

Cancer chemotherapy and pharmacology, 2002-09, Vol.50 (3), p.223-229

2002

Volltextzugriff (PDF)

Final results of phase II trial of pegylated arginine deiminase (ADI-PEG20) in metastatic melanoma (MM)

Journal of clinical oncology, 2010-05, Vol.28 (15_suppl), p.8528-8528

2010

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Prognostic factors in metastatic carcinoma of unknown primary

Journal of clinical oncology, 1986-11, Vol.4 (11), p.1652-1657

1986

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Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression

Pancreas, 2005-03, Vol.30 (2), p.e34-e39

2005

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Cardiostimulatory and Antiarrhythmic Activity of Tubulin-Binding Agents

Proceedings of the National Academy of Sciences - PNAS, 1992-02, Vol.89 (4), p.1256-1260

1992

Volltextzugriff (PDF)

Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern-synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives

European journal of medicinal chemistry, 2003-01, Vol.38 (1), p.101-107

2003

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Overcoming cisplatin resistance with mTOR inhibition in small cell lung cancer: A phase I-II trial design

Journal of clinical oncology, 2008-05, Vol.26 (15_suppl), p.14673-14673

2008

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Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells

Leukemia, 1997-07, Vol.11 (7), p.1156-1159

1997

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Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump

Biochemical and biophysical research communications, 1998-06, Vol.247 (3), p.859-863

1998

Volltextzugriff (PDF)

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Arginine deprivation as a targeted therapy for cancer

Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

Hypersensitization of Tumor Cells to Glycolytic Inhibitors

2-deoxy-d-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells

Pegylated Arginine Deiminase Treatment of Patients With Metastatic Melanoma: Results From Phase I and II Studies

Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers

Circumvention of P-GP MDR as a Function of Anthracycline Lipophilicity and Charge

Phase I and Pharmacokinetic Study of Triapine, a Potent Ribonucleotide Reductase Inhibitor, Administered Daily for Five Days in Patients with Advanced Solid Tumors

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C)

CS-03 UTILIZING COLLAGEN AND DISCOIDIN DOMAIN RECEPTOR SIGNALING AS A NEWTHERAPEUTIC STRATEGY IN HUMAN MALIGNANT GLIOMA

Phase II trial of SOM230 (pasireotide LAR) in patients with unresectable hepatocellular carcinoma

Determining argininosuccinate synthetase (ASS) expression in patients with melanoma treated with arginine depleting therapy

Role of concurrent chemoradiotherapy in organ preservation for locally advanced head and neck cancer

Phase II study of vinorelbine with low dose prednisone in the treatment of hormone-refractory metastatic prostate cancer

Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule

Final results of phase II trial of pegylated arginine deiminase (ADI-PEG20) in metastatic melanoma (MM)

Prognostic factors in metastatic carcinoma of unknown primary

Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression

Cardiostimulatory and Antiarrhythmic Activity of Tubulin-Binding Agents

Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern-synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives

Overcoming cisplatin resistance with mTOR inhibition in small cell lung cancer: A phase I-II trial design

Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells

Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump

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