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Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

British journal of cancer, 2001-05, Vol.84 (10), p.1424-1431

2001

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Developmental Therapeutics Program at the NCI: molecular target and drug discovery process

Leukemia, 2002-04, Vol.16 (4), p.520-526

2002

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Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

JNCI : Journal of the National Cancer Institute, 2000-03, Vol.92 (5), p.376-387

2000

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Proteasome inhibitors : A novel class of potent and effective antitumor agents

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (11), p.2615-2622

1999

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A gene expression database for the molecular pharmacology of cancer

Nature genetics, 2000-03, Vol.24 (3), p.236-244

2000

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Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms

Journal of clinical oncology, 1998-09, Vol.16 (9), p.2986-2999

1998

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DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

British journal of cancer, 2003-02, Vol.88 (4), p.599-605

2003

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Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin

The Journal of biological chemistry, 1994-05, Vol.269 (21), p.14869-14871

1994

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Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

Journal of medicinal chemistry, 1999-07, Vol.42 (15), p.2909-2919

1999

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Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

Journal of clinical oncology, 2001-04, Vol.19 (8), p.2319-2333

2001

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UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

JNCI : Journal of the National Cancer Institute, 1996-07, Vol.88 (14), p.956-965

1996

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Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents

Cancer research (Chicago, Ill.), 1997-10, Vol.57 (19), p.4285-4300

1997

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In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles

British journal of cancer, 2002-04, Vol.86 (8), p.1348-1354

2002

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Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol

Cancer research (Chicago, Ill.), 1999-09, Vol.59 (18), p.4634-4641

1999

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Antitumor Benzothiazoles. 8. Synthesis, Metabolic Formation, and Biological Properties of the C- and N-Oxidation Products of Antitumor 2-(4-Aminophenyl)benzothiazoles

Journal of medicinal chemistry, 1999-10, Vol.42 (20), p.4172-4184

1999

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Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (11), p.2566-2569

1999

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Targeted Toxins

Clinical cancer research, 2000-02, Vol.6 (2), p.326-334

2000

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Major clinical response to nivolumab in relapsed/refractory Hodgkin lymphoma after allogeneic stem cell transplantation

Bone marrow transplantation (Basingstoke), 2016-06, Vol.51 (6), p.850-852

2016

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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2797-2804

2000

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Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes

Cancer research (Chicago, Ill.), 1999-11, Vol.59 (21), p.5433-5437

1999

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Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors

Clinical cancer research, 1998-03, Vol.4 (3), p.629-634

1998

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BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells

The Journal of biological chemistry, 1993-03, Vol.268 (8), p.5979-5984

1993

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Role of CYP1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells

Cancer research (Chicago, Ill.), 2000-09, Vol.60 (18), p.5196-5203

2000

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Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes

Cell death and differentiation, 2006-01, Vol.13 (1), p.151-159

2006

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Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts

Blood, 1998-04, Vol.91 (7), p.2482-2490

1998

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Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

Developmental Therapeutics Program at the NCI: molecular target and drug discovery process

Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

Proteasome inhibitors : A novel class of potent and effective antitumor agents

A gene expression database for the molecular pharmacology of cancer

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms

DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin

Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents

In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles

Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol

Antitumor Benzothiazoles. 8. Synthesis, Metabolic Formation, and Biological Properties of the C- and N-Oxidation Products of Antitumor 2-(4-Aminophenyl)benzothiazoles

Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases

Targeted Toxins

Major clinical response to nivolumab in relapsed/refractory Hodgkin lymphoma after allogeneic stem cell transplantation

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes

Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors

BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells

Role of CYP1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells

Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes

Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts

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