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The Current Status and Prospects of Antibody Engineering for Therapeutic Use: Focus on Glycoengineering Technology

Journal of pharmaceutical sciences, 2015-03, Vol.104 (3), p.930-941

2015

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Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5

Cytokine (Philadelphia, Pa.), 2017-10, Vol.98, p.59-70

2017

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Production of therapeutic antibodies with controlled fucosylation

mAbs, 2009-05, Vol.1 (3), p.230-236

2009

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Engineered therapeutic antibodies with improved effector functions

Cancer science, 2009-09, Vol.100 (9), p.1566-1572

2009

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Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC

Drug design, development and therapy, 2009-09, Vol.3 (default), p.7-16

2009

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Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1

Journal of molecular biology, 2007-05, Vol.368 (3), p.767-779

2007

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Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies

Expert opinion on biological therapy, 2006-11, Vol.6 (11), p.1161-1173

2006

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Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors

PloS one, 2015-10, Vol.10 (10), p.e0140120-e0140120

2015

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The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

The Journal of biological chemistry, 2003-01, Vol.278 (5), p.3466-3473

2003

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Nonfucosylated Therapeutic IgG1 Antibody Can Evade the Inhibitory Effect of Serum Immunoglobulin G on Antibody-Dependent Cellular Cytotoxicity through its High Binding to FcγRIIIa

Clinical cancer research, 2006-05, Vol.12 (9), p.2879-2887

2006

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A Peptidomics Strategy for Discovering Endogenous Bioactive Peptides

Journal of proteome research, 2010-10, Vol.9 (10), p.5047-5052

2010

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Engineered anti‐CD20 antibodies with enhanced complement‐activating capacity mediate potent anti‐lymphoma activity

Cancer science, 2009-12, Vol.100 (12), p.2411-2418

2009

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Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

BMC cancer, 2009-02, Vol.9 (1), p.58-58, Article 58

2009

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Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

BMC biotechnology, 2007-11, Vol.7 (1), p.84-84, Article 84

2007

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A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

Clinical cancer research, 2007-03, Vol.13 (6), p.1875-1882

2007

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Establishment of a GDP-mannose 4,6-dehydratase ( GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics

Journal of biotechnology, 2007-06, Vol.130 (3), p.300-310

2007

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Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA

Biotechnology and bioengineering, 2004-12, Vol.88 (7), p.901-908

2004

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Non-fucosylated therapeutic antibodies : the next generation of therapeutic antibodies

Cytotechnology (Dordrecht), 2007-12, Vol.55 (2-3), p.109-114

2007

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Fucose Removal from Complex-Type Oligosaccharide Enhances the Antibody-Dependent Cellular Cytotoxicity of Single-Gene-Encoded Bispecific Antibody Comprising of Two Single-Chain Antibodies Linked to the Antibody Constant Region

Journal of biochemistry (Tokyo), 2006-09, Vol.140 (3), p.359-368

2006

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Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

Genes to cells : devoted to molecular & cellular mechanisms, 2011-11, Vol.16 (11), p.1071-1080

2011

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Identification of the functional expression of adenosine A₃ receptor in pancreas using transgenic mice expressing jellyfish apoaequorin

Transgenic research, 2007-08, Vol.16 (4), p.429-435

2007

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Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

Glycobiology (Oxford), 2007, Vol.17 (1), p.104-118

2007

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Nonfucosylated rituximab potentiates human neutrophil phagocytosis through its high binding for FcγRIIIb and MHC class II expression on the phagocytotic neutrophils

Experimental hematology, 2009-03, Vol.37 (3), p.309-321

2009

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Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities

Cancer research (Chicago, Ill.), 2008-05, Vol.68 (10), p.3863-3872

2008

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One-Step Induction of Neurons from Mouse Embryonic Stem Cells in Serum-Free Media Containing Vitamin B12 and Heparin

Cell transplantation, 2006, Vol.15 (2), p.135-145

2006

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The Current Status and Prospects of Antibody Engineering for Therapeutic Use: Focus on Glycoengineering Technology

Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5

Production of therapeutic antibodies with controlled fucosylation

Engineered therapeutic antibodies with improved effector functions

Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC

Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1

Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies

Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors

The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

Nonfucosylated Therapeutic IgG1 Antibody Can Evade the Inhibitory Effect of Serum Immunoglobulin G on Antibody-Dependent Cellular Cytotoxicity through its High Binding to FcγRIIIa

A Peptidomics Strategy for Discovering Endogenous Bioactive Peptides

Engineered anti‐CD20 antibodies with enhanced complement‐activating capacity mediate potent anti‐lymphoma activity

Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients

Establishment of a GDP-mannose 4,6-dehydratase ( GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics

Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA

Non-fucosylated therapeutic antibodies : the next generation of therapeutic antibodies

Fucose Removal from Complex-Type Oligosaccharide Enhances the Antibody-Dependent Cellular Cytotoxicity of Single-Gene-Encoded Bispecific Antibody Comprising of Two Single-Chain Antibodies Linked to the Antibody Constant Region

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

Identification of the functional expression of adenosine A₃ receptor in pancreas using transgenic mice expressing jellyfish apoaequorin

Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

Nonfucosylated rituximab potentiates human neutrophil phagocytosis through its high binding for FcγRIIIb and MHC class II expression on the phagocytotic neutrophils

Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities

One-Step Induction of Neurons from Mouse Embryonic Stem Cells in Serum-Free Media Containing Vitamin B12 and Heparin

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