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Robust network topologies for generating switch-like cellular responses

PLoS computational biology, 2011-06, Vol.7 (6), p.e1002085-e1002085

2011

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Rapid retinoic acid-induced trophoblast cell model from human induced pluripotent stem cells

Scientific reports, 2024-08, Vol.14 (1), p.18204-15, Article 18204

2024

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Model-guided engineering of DNA sequences with predictable site-specific recombination rates

Nature communications, 2022-07, Vol.13 (1), p.4152-4152, Article 4152

2022

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MVsim is a toolset for quantifying and designing multivalent interactions

Nature communications, 2022-09, Vol.13 (1), p.5029-5029, Article 5029

2022

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A cell-free approach to identify binding hotspots in plant immune receptors

Scientific reports, 2022-01, Vol.12 (1), p.501-501, Article 501

2022

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Variable cellular decision-making behavior in a constant synthetic network topology

BMC bioinformatics, 2019-05, Vol.20 (1), p.237-237, Article 237

2019

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Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (39), p.14808-14813

2008

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Engineering Signal Peptides for Enhanced Protein Secretion from Lactococcus lactis

Applied and Environmental Microbiology, 2013-01, Vol.79 (1), p.347-356

2013

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Quantifying cell fate decisions for differentiation and reprogramming of a human stem cell network: landscape and biological paths

PLoS computational biology, 2013-08, Vol.9 (8), p.e1003165-e1003165

2013

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Conceptual and methodological advances in cell-free directed evolution

Current opinion in structural biology, 2015-08, Vol.33, p.1-7

2015

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Inertial effect of cell state velocity on the quiescence-proliferation fate decision

NPJ systems biology and applications, 2024-10, Vol.10 (1), p.111-14, Article 111

2024

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Transient Noise Amplification and Gene Expression Synchronization in a Bistable Mammalian Cell-Fate Switch

Cell reports (Cambridge), 2012-03, Vol.1 (3), p.215-224

2012

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Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanism

Molecular pharmacology, 2005-11, Vol.68 (5), p.1439-1454

2005

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Synthetic conversion of a graded receptor signal into a tunable, reversible switch

Molecular systems biology, 2011-03, Vol.7 (1), p.480-n/a

2011

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Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution

Protein engineering, design and selection, 2010-04, Vol.23 (4), p.175-184

2010

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Positive Receptor Feedback during Lineage Commitment Can Generate Ultrasensitivity to Ligand and Confer Robustness to a Bistable Switch

Biophysical journal, 2008-08, Vol.95 (4), p.1575-1589

2008

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Towards a Quantitative Understanding of Cell Identity

Trends in cell biology, 2018-12, Vol.28 (12), p.1030-1048

2018

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Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (51), p.25659-25667

2019

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Toward Bioremediation of Methylmercury Using Silica Encapsulated Escherichia coli Harboring the mer Operon

PloS one, 2016-01, Vol.11 (1), p.e0147036

2016

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Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors

PLoS computational biology, 2009-09, Vol.5 (9), p.e1000518-e1000518

2009

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Facile Display of Homomultivalent Proteins for In Vitro Selections

ACS synthetic biology, 2023-02, Vol.12 (2), p.634-638

2023

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Trajectory-based energy landscapes of gene regulatory networks

Biophysical journal, 2021-02, Vol.120 (4), p.687-698

2021

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Broad-specificity mRNA-rRNA complementarity in efficient protein translation

PLoS genetics, 2012-03, Vol.8 (3), p.e1002598-e1002598

2012

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Engineering a Minimal Leucine-rich Repeat IgG-binding Module

Applied biochemistry and biotechnology, 2022-04, Vol.194 (4), p.1636-1644

2022

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Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching"

Nature biotechnology, 2002-09, Vol.20 (9), p.908-913

2002

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Robust network topologies for generating switch-like cellular responses

Rapid retinoic acid-induced trophoblast cell model from human induced pluripotent stem cells

Model-guided engineering of DNA sequences with predictable site-specific recombination rates

MVsim is a toolset for quantifying and designing multivalent interactions

A cell-free approach to identify binding hotspots in plant immune receptors

Variable cellular decision-making behavior in a constant synthetic network topology

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

Engineering Signal Peptides for Enhanced Protein Secretion from Lactococcus lactis

Quantifying cell fate decisions for differentiation and reprogramming of a human stem cell network: landscape and biological paths

Conceptual and methodological advances in cell-free directed evolution

Inertial effect of cell state velocity on the quiescence-proliferation fate decision

Transient Noise Amplification and Gene Expression Synchronization in a Bistable Mammalian Cell-Fate Switch

Protein PEGylation Decreases Observed Target Association Rates via a Dual Blocking Mechanism

Synthetic conversion of a graded receptor signal into a tunable, reversible switch

Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution

Positive Receptor Feedback during Lineage Commitment Can Generate Ultrasensitivity to Ligand and Confer Robustness to a Bistable Switch

Towards a Quantitative Understanding of Cell Identity

Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

Toward Bioremediation of Methylmercury Using Silica Encapsulated Escherichia coli Harboring the mer Operon

Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors

Facile Display of Homomultivalent Proteins for In Vitro Selections

Trajectory-based energy landscapes of gene regulatory networks

Broad-specificity mRNA-rRNA complementarity in efficient protein translation

Engineering a Minimal Leucine-rich Repeat IgG-binding Module

Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching"

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