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Adamts5 Deletion Blocks Murine Dermal Repair through CD44-mediated Aggrecan Accumulation and Modulation of Transforming Growth Factor β1 (TGFβ1) Signaling

The Journal of biological chemistry, 2011-07, Vol.286 (29), p.26016-26027

2011

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Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

Arthritis research & therapy, 2012-06, Vol.14 (3), p.R151-R151

2012

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Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling

Tissue engineering. Part A, 2011-01, Vol.17 (1-2), p.83

2011

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Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

Arthritis research & therapy, 2011-03, Vol.13 (2), p.R46-R46, Article R46

2011

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ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1

The Journal of biological chemistry, 2004-03, Vol.279 (11), p.10042-10051

2004

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Processing and Localization of ADAMTS-1 and Proteolytic Cleavage of Versican during Cumulus Matrix Expansion and Ovulation

The Journal of biological chemistry, 2003-10, Vol.278 (43), p.42330-42339

2003

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Biochemical identification and immunolocalizaton of aggrecan, ADAMTS5 and inter-alpha-trypsin-inhibitor in equine degenerative suspensory ligament desmitis

Journal of orthopaedic research, 2011-06, Vol.29 (6), p.900-906

2011

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Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation

The Journal of biological chemistry, 2002-03, Vol.277 (13), p.11034-11041

2002

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Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

Gene Expression Patterns, 2009-06, Vol.9 (5), p.314-323

2009

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Regulated Expression of ADAMTS Family Members in Follicles and Cumulus Oocyte Complexes: Evidence for Specific and Redundant Patterns During Ovulation

Biology of reproduction, 2005-05, Vol.72 (5), p.1241-1255

2005

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Cell Death-associated ADAMTS4 and Versican Degradation in Vascular Tissue

The journal of histochemistry and cytochemistry, 2009-09, Vol.57 (9), p.889-897

2009

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Multimodal signaling by the ADAMTSs ( a disintegrin and metalloproteinase with thrombo spondin motifs) promotes neurite extension

Experimental neurology, 2008-04, Vol.210 (2), p.428-440

2008

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Aggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes - Then and Now

Advances in experimental medicine and biology, 2023, Vol.1402, p.3

2023

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Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications

Arthritis research & therapy, 2009-01, Vol.11 (6), p.R173-R173

2009

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In‐Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy

Journal of orthopaedic research, 2020-01, Vol.38 (1), p.59-69

2020

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Intact aggrecan and chondroitin sulfate-depleted aggrecan core glycoprotein inhibit axon growth in the adult rat spinal cord

Experimental neurology, 2003-12, Vol.184 (2), p.981-990

2003

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Genome‐wide analysis identifies differential promoter methylation of Leprel2, Foxf1, Mmp25, Igfbp6, and Peg12 in murine tendinopathy

Journal of orthopaedic research, 2017-05, Vol.35 (5), p.947-955

2017

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Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models

Journal of orthopaedic research, 2011-04, Vol.29 (4), p.516-522

2011

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Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration

Spine (Philadelphia, Pa. 1976), 2007-11, Vol.32 (23), p.2596-2603

2007

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TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells

Connective tissue research, 2018-09, Vol.59 (5), p.458-471

2018

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Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa

Journal of orthopaedic research, 2018-10, Vol.36 (10), p.2622-2632

2018

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ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain

The Journal of biological chemistry, 2002-05, Vol.277 (18), p.16059-16066

2002

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Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5

Journal of orthopaedic research, 2012-04, Vol.30 (4), p.620-626

2012

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Effect of intra-articular hyaluronan injection on inflammation and bone remodeling in the epiphyses and metaphyses of the knee in a murine model of joint injury

American journal of translational research, 2019-01, Vol.11 (6), p.3280-3300

2019

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Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model

Journal of biomechanics, 2013-02, Vol.46 (3), p.498-505

2013

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Adamts5 Deletion Blocks Murine Dermal Repair through CD44-mediated Aggrecan Accumulation and Modulation of Transforming Growth Factor β1 (TGFβ1) Signaling

Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling

Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1

Processing and Localization of ADAMTS-1 and Proteolytic Cleavage of Versican during Cumulus Matrix Expansion and Ovulation

Biochemical identification and immunolocalizaton of aggrecan, ADAMTS5 and inter-alpha-trypsin-inhibitor in equine degenerative suspensory ligament desmitis

Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

Regulated Expression of ADAMTS Family Members in Follicles and Cumulus Oocyte Complexes: Evidence for Specific and Redundant Patterns During Ovulation

Cell Death-associated ADAMTS4 and Versican Degradation in Vascular Tissue

Multimodal signaling by the ADAMTSs ( a disintegrin and metalloproteinase with thrombo spondin motifs) promotes neurite extension

Aggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes - Then and Now

Aggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications

In‐Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy

Intact aggrecan and chondroitin sulfate-depleted aggrecan core glycoprotein inhibit axon growth in the adult rat spinal cord

Genome‐wide analysis identifies differential promoter methylation of Leprel2, Foxf1, Mmp25, Igfbp6, and Peg12 in murine tendinopathy

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models

Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration

TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells

Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa

ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain

Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5

Effect of intra-articular hyaluronan injection on inflammation and bone remodeling in the epiphyses and metaphyses of the knee in a murine model of joint injury

Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model

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