UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 63

Sortiert nach

BioPrint meets the AI age: development of artificial intelligence-based ADMET models for the drug discovery platform SAFIRE

Future medicinal chemistry, 2024-04, Vol.16 (7), p.587-599

2024

Link zum Volltext

Verfügbarkeit prüfen

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (5), p.126929, Article 126929

2020

Link zum Volltext

Verfügbarkeit prüfen

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3134-3141

2011

Link zum Volltext

Verfügbarkeit prüfen

Elucidating Molecular Overlays from Pairwise Alignments Using a Genetic Algorithm

Journal of Chemical Information and Modeling, 2009-07, Vol.49 (7), p.1847-1855

2009

Link zum Volltext

Verfügbarkeit prüfen

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1750-1755

2012

Link zum Volltext

Verfügbarkeit prüfen

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 2C receptor

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (24), p.5877-5882

2016

Link zum Volltext

Verfügbarkeit prüfen

1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b

Journal of medicinal chemistry, 2006-02, Vol.49 (4), p.1227-1230

2006

Link zum Volltext

Verfügbarkeit prüfen

Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b

Journal of medicinal chemistry, 2007-04, Vol.50 (7), p.1445-1448

2007

Link zum Volltext

Verfügbarkeit prüfen

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (9), p.2797-2800

2010

Link zum Volltext

Verfügbarkeit prüfen

5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4207-4209

2009

Link zum Volltext

Verfügbarkeit prüfen

Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure

Results in Chemistry, 2022-01, Vol.4, p.100518, Article 100518

2022

Link zum Volltext

Verfügbarkeit prüfen

A new family of H3 receptor antagonists based on the natural product Conessine

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1490-1494

2008

Link zum Volltext

Verfügbarkeit prüfen

3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b

Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6619-6622

2007

Link zum Volltext

Verfügbarkeit prüfen

Agonist lead identification for the high affinity niacin receptor GPR109a

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4914-4919

2007

Link zum Volltext

Verfügbarkeit prüfen

The additivity of substrate fragments in enzyme–ligand binding

Structure (London), 1998-07, Vol.6 (7), p.839-848

1998

Link zum Volltext

Verfügbarkeit prüfen

Molecular Hashkeys: A Novel Method for Molecular Characterization and Its Application for Predicting Important Pharmaceutical Properties of Molecules

Journal of medicinal chemistry, 1999-05, Vol.42 (10), p.1739-1748

1999

Link zum Volltext

Verfügbarkeit prüfen

Mutation in the β-Tubulin Signature Motif Suppresses Microtubule GTPase Activity and Dynamics, and Slows Mitosis

Biochemistry (Easton), 2001-12, Vol.40 (51), p.15725-15732

2001

Link zum Volltext

Verfügbarkeit prüfen

D221 in Thymidylate Synthase Controls Conformation Change, and Thereby Opening of the Imidazolidine

Biochemistry (Easton), 1998-09, Vol.37 (39), p.13893-13901

1998

Link zum Volltext

Verfügbarkeit prüfen

Investigating interactions between phentermine, dexfenfluramine, and 5-HT.sub.2C agonists, on food intake in the rat

Psychopharmacology, 2015-06, Vol.232 (11), p.1973

2015

Link zum Volltext

Verfügbarkeit prüfen

Investigating interactions between phentermine, dexfenfluramine, and 5-HT^sub 2C^ agonists, on food intake in the rat

Psychopharmacology, 2015-06, Vol.232 (11), p.1973

2015

Link zum Volltext

Verfügbarkeit prüfen

Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat

Psychopharmacology, 2015-06, Vol.232 (11), p.1973-1982

2015

Link zum Volltext

Verfügbarkeit prüfen

G-Protein Coupled Receptors Virtual Screening Using Genetic Algorithm Focused Chemical Space

Journal of chemical information and modeling, 2011-08, Vol.51 (8), p.1754-1761

2011

Link zum Volltext

Verfügbarkeit prüfen

1 – 25 von 63

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(54)
Mit Volltextzugriff
(61)

Publikationsform

Sprache

Englisch
(63)
Japanisch
(7)

Erscheinungsjahr

n.n

Thema

Science & Technology
(31)
Life Sciences & Biomedicine
(29)
Pharmacology & Pharmacy
(21)
Chemistry, Medicinal
(20)
Animals
(18)
Biological And Medical Sciences
(15)
Humans
(14)
Chemistry
(13)
Medical Sciences
(13)
Pharmacology. Drug Treatments
(13)
Physical Sciences
(13)
Rats
(11)
Receptors, G-Protein-Coupled - Agonists
(11)
Chemistry, Organic
(10)
Drug Discovery
(10)
Structure-Activity Relationship
(10)
Mediaeval History
(8)
Biochemistry & Molecular Biology
(7)
General And Cellular Metabolism. Vitamins
(7)
Binding Sites
(6)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

BioPrint meets the AI age: development of artificial intelligence-based ADMET models for the drug discovery platform SAFIRE

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Discovery of 2‑(((1r,4r)‑4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Elucidating Molecular Overlays from Pairwise Alignments Using a Genetic Algorithm

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 2C receptor

1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b

Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)

5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b

Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure

A new family of H3 receptor antagonists based on the natural product Conessine

3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b

Agonist lead identification for the high affinity niacin receptor GPR109a

The additivity of substrate fragments in enzyme–ligand binding

Molecular Hashkeys: A Novel Method for Molecular Characterization and Its Application for Predicting Important Pharmaceutical Properties of Molecules

Mutation in the β-Tubulin Signature Motif Suppresses Microtubule GTPase Activity and Dynamics, and Slows Mitosis

D221 in Thymidylate Synthase Controls Conformation Change, and Thereby Opening of the Imidazolidine

Investigating interactions between phentermine, dexfenfluramine, and 5-HT.sub.2C agonists, on food intake in the rat

Investigating interactions between phentermine, dexfenfluramine, and 5-HT^sub 2C^ agonists, on food intake in the rat

Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat

G-Protein Coupled Receptors Virtual Screening Using Genetic Algorithm Focused Chemical Space

Suchergebnisse filtern