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HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target

Clinical cancer research, 2018-05, Vol.24 (10), p.2395-2407

2018

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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.180-201

2017

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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

Journal of medicinal chemistry, 2023-04, Vol.66 (8), p.5907-5936

2023

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The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases

Carbohydrate research, 2004-02, Vol.339 (3), p.699-703

2004

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Glycosidase mechanisms

Current Opinion in Chemical Biology, 2000-10, Vol.4 (5), p.573-580

2000

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A model β-sheet interaction and thermodynamic analysis of β-strand mimetics

Organic & biomolecular chemistry, 2015-07, Vol.13 (27), p.7402-7407

2015

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Privileged Structures and Polypharmacology within and between Protein Families

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1199-1204

2018

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Elucidation of the Mechanism of Polysaccharide Cleavage by Chondroitin AC Lyase from Flavobacterium heparinum

Journal of the American Chemical Society, 2002-08, Vol.124 (33), p.9756-9767

2002

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

MedChemComm, 2016-08, Vol.7 (8), p.1580-1586

2016

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Structure-Guided Rescaffolding of Selective Antagonists of BCL‑XL

ACS medicinal chemistry letters, 2014-06, Vol.5 (6), p.662-667

2014

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Atypical Approach Identifies TYR234 as the Key Base Catalyst in Chondroitin AC Lyase

Chembiochem : a European journal of chemical biology, 2006-04, Vol.7 (4), p.631-637

2006

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Synthesis and Evaluation of Potential Inhibitors of Chondroitin AC Lyase from Flavobacterium heparinum

Journal of organic chemistry, 2002-06, Vol.67 (13), p.4505-4512

2002

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Development of an assay and determination of kinetic parameters for chondroitin AC lyase using defined synthetic substrates

Analytical biochemistry, 2002-09, Vol.308 (1), p.77-82

2002

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Elucidation of the Mechanism of Polysaccharide Cleavage by Chondroitin AC Lyase from Flavobacterium h eparinum

Journal of the American Chemical Society, 2002-08, Vol.124 (33), p.9756-9767

2002

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Synthesis and Evaluation of Potential Inhibitors of Chondroitin AC Lyase from Flavobacterium h eparinum

Journal of organic chemistry, 2002-06, Vol.67 (13), p.4505-4512

2002

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A model β-sheet interaction and thermodynamic analysis of β-strand mimeticsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ob00886g

2015-07

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Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.LB-304-LB-304

2017

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Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

ACS medicinal chemistry letters, 2014-06, Vol.5 (6), p.662-667

2014

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Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases

Tetrahedron, 2007-04, Vol.63 (16), p.3306-3311

2007

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9The authors declare the following competing financial interest(s): C. Rye, N. Chessum, L. Zani, M. Cheeseman, F. Raynaud, A. Hayes, A. Henley, E. de Billy, C. Lynch, S. Sharp, R. te Poele, L. O'Fee, P. Workman, and K. Jones are or have been employees of The Institute of Cancer Research which has a commercial interest in the development of HSF1 inhibitors. Authors who are or ha

2016-08

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9† †The authors declare the following competing financial interest(s): C. Rye, N. Chessum, L. Zani, M. Cheeseman, F. Raynaud, A. Hayes, A. Henley, E. de Billy, C. Lynch, S. Sharp, R. te Poele, L. O'Fee, P. Workman, and K. Jones are or have been employees of The Institute of Cancer Research which has a commercial interest in the development of HSF1 inhibitors. Authors who are or

MedChemComm, 2016-06, Vol.7 (8), p.1580-1586

2016

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Lignin inhibits autoxidative degradation of cellulose

Polymer degradation and stability, 1995, Vol.49 (2), p.291-297

1995

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Mechanistic studies of chondroitin AC lyase from Flavobacterium heparinum

Rye, Carl S

2002

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Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39

Thorax, 2023-02, Vol.78 (2), p.151-159

2023

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HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases

Glycosidase mechanisms

A model β-sheet interaction and thermodynamic analysis of β-strand mimetics

Privileged Structures and Polypharmacology within and between Protein Families

Elucidation of the Mechanism of Polysaccharide Cleavage by Chondroitin AC Lyase from Flavobacterium heparinum

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

Structure-Guided Rescaffolding of Selective Antagonists of BCL‑XL

Correction: Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. See DOI: 10.1039/c6md00159a

Atypical Approach Identifies TYR234 as the Key Base Catalyst in Chondroitin AC Lyase

Synthesis and Evaluation of Potential Inhibitors of Chondroitin AC Lyase from Flavobacterium heparinum

Development of an assay and determination of kinetic parameters for chondroitin AC lyase using defined synthetic substrates

Elucidation of the Mechanism of Polysaccharide Cleavage by Chondroitin AC Lyase from Flavobacterium h eparinum

Synthesis and Evaluation of Potential Inhibitors of Chondroitin AC Lyase from Flavobacterium h eparinum

A model β-sheet interaction and thermodynamic analysis of β-strand mimeticsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ob00886g

Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases

Lignin inhibits autoxidative degradation of cellulose

Mechanistic studies of chondroitin AC lyase from Flavobacterium heparinum

Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39

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