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Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

Trends in biochemical sciences (Amsterdam. Regular ed.), 2015-04, Vol.40 (4), p.200-210

2015

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ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Stem cell reports, 2016-03, Vol.6 (3), p.342-356

2016

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Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

Movement disorders, 2018-10, Vol.33 (10), p.1580-1590

2018

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Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

Trends in biochemical sciences (Amsterdam. Regular ed.), 2021-04, Vol.46 (4), p.329-343

2021

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Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases

Redox biology, 2014-01, Vol.2 (C), p.715-724

2014

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Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Molecular neurodegeneration, 2023-11, Vol.18 (1), p.87-87, Article 87

2023

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Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Molecular neurodegeneration, 2023-12, Vol.18 (1), p.96-96, Article 96

2023

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PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

Frontiers in cellular neuroscience, 2019-07, Vol.13, p.297-297

2019

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Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons

Cell reports (Cambridge), 2023-03, Vol.42 (3), p.112180-112180, Article 112180

2023

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Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

Frontiers in cellular neuroscience, 2021-04, Vol.15, p.658244

2021

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Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis

Mediators of Inflammation, 2014-01, Vol.2014 (5), p.75-93

2014

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Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Molecular neurodegeneration, 2017-10, Vol.12 (1), p.79-79, Article 79

2017

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Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons

Human molecular genetics, 2019-06, Vol.28 (12), p.2001-2013

2019

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CRISPRi: a way to integrate iPSC-derived neuronal models

Biochemical Society transactions, 2024-04, Vol.52 (2), p.539-551

2024

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Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

Cell stem cell, 2019-01, Vol.24 (1), p.93-106.e6

2019

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REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model

The Journal of neuroscience, 2021-04, Vol.41 (16), p.3731-3746

2021

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A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

Free radical biology & medicine, 2017-03, Vol.104, p.214-225

2017

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Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease

Scientific reports, 2015-11, Vol.5 (1), p.17004, Article 17004

2015

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Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models

Human molecular genetics, 2023-09, Vol.32 (18), p.2808-2821

2023

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Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

Autophagy, 2023-02, Vol.19 (2), p.692-705

2023

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Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism

Stem cell reports, 2021-06, Vol.16 (6), p.1510-1526

2021

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Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase

Molecular neurobiology, 2019-03, Vol.56 (3), p.1558-1577

2019

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A requirement for Gch1 and tetrahydrobiopterin in embryonic development

Developmental biology, 2015-03, Vol.399 (1), p.129-138

2015

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Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens

Free radical biology & medicine, 2013-04, Vol.57, p.79-91

2013

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α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

Free radical biology & medicine, 2014-02, Vol.67, p.58-68

2014

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Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons

CRISPRi: a way to integrate iPSC-derived neuronal models

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance

Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease

Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism

Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

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