UB Paderborn / Katalog / Suche / in CDI

Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017-09, Vol.1061-1062, p.356-363

2017

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The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates

Drug metabolism and disposition, 2017-09, Vol.45 (9), p.1008-1018

2017

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Signature peptide selection workflow for biomarker quantification using LC–MS-based targeted proteomics

Bioanalysis, 2023-03, Vol.15 (5), p.295-300

2023

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Comparison of three parallelism assessment methods of biomarker quantification by LC-MS/MS: a case study of the bioanalysis of creatinine in human urine samples

Bioanalysis, 2022-03, Vol.14 (5), p.279-287

2022

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The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1227

2008

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Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1184-1192

2016

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The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1819-1827

2016

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Characterization of the expression and activity of carboxylesterases 1 and 2 from the beagle dog, cynomolgus monkey, and human

Drug metabolism and disposition, 2011-12, Vol.39 (12), p.2305

2011

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In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug

Drug metabolism and disposition, 2015-05, Vol.43 (5), p.756-761

2015

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Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7

Drug metabolism and disposition, 2002-08, Vol.30 (8), p.883

2002

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Validation of 96-well Equilibrium Dialysis with Non-radiolabeled Drug for Definitive Measurement of Protein Binding and Application to Clinical Development of Highly-Bound Drugs

Journal of pharmaceutical sciences, 2011-06, Vol.100 (6), p.2498-2507

2011

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High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC–MS/MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013-08, Vol.932, p.117-122

2013

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Stereoselective metabolism of prasugrel in humans using a novel chiral liquid chromatography-tandem mass spectrometry method

Drug metabolism and disposition, 2007-06, Vol.35 (6), p.917

2007

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Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse

Journal of pharmacy & pharmaceutical sciences, 2016-10, Vol.19 (4), p.496

2016

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Preclinical bridging studies: understanding dried blood spot and plasma exposure profiles

Bioanalysis, 2013-01, Vol.5 (2), p.159-170

2013

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A homologous series of internal standards for near universal application in the discovery LC-MS/MS bioanalytical laboratory

Journal of pharmaceutical and biomedical analysis, 2020-10, Vol.190, p.113578, Article 113578

2020

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Analytical method considerations regarding carryover for monophosphate prodrugs for in vivo samples by liquid chromatography-tandem mass spectrometry

Journal of Chromatography A, 2019-11, Vol.1606, p.460379, Article 460379

2019

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Dried blood spot sampling: coupling bioanalytical feasibility, blood-plasma partitioning and transferability to in vivo preclinical studies

Bioanalysis, 2011-07, Vol.3 (14), p.1635-1646

2011

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Correction to: A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice

Pharmaceutical research, 2018-09, Vol.35 (9), p.180-1, Article 180

2018

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A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice

Pharmaceutical research, 2018-08, Vol.35 (8), p.162-13, Article 162

2018

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Integrity and efficiency: AbbVie’s journey of building an integrated nonregulated bioanalytical laboratory

Bioanalysis, 2023-02, Vol.15 (3), p.161-176

2023

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Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of α-methyltyrosine in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004-10, Vol.810 (2), p.229-234

2004

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Implications of In Vitro System Conditions for CYP2C9 and CYP3A4: Impact of pH on Clearance and Enzyme Inhibition

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LCaMS/MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013-08, Vol.932, p.117-122

2013

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A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro

Journal of pharmacological and toxicological methods, 2001-09, Vol.46 (2), p.117-123

2001

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Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue

The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates

Signature peptide selection workflow for biomarker quantification using LC–MS-based targeted proteomics

Comparison of three parallelism assessment methods of biomarker quantification by LC-MS/MS: a case study of the bioanalysis of creatinine in human urine samples

The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2

Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats

The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates

Characterization of the expression and activity of carboxylesterases 1 and 2 from the beagle dog, cynomolgus monkey, and human

In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7

Validation of 96-well Equilibrium Dialysis with Non-radiolabeled Drug for Definitive Measurement of Protein Binding and Application to Clinical Development of Highly-Bound Drugs

High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC–MS/MS

Stereoselective metabolism of prasugrel in humans using a novel chiral liquid chromatography-tandem mass spectrometry method

Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse

Preclinical bridging studies: understanding dried blood spot and plasma exposure profiles

A homologous series of internal standards for near universal application in the discovery LC-MS/MS bioanalytical laboratory

Analytical method considerations regarding carryover for monophosphate prodrugs for in vivo samples by liquid chromatography-tandem mass spectrometry

Dried blood spot sampling: coupling bioanalytical feasibility, blood-plasma partitioning and transferability to in vivo preclinical studies

Correction to: A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice

A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice

Integrity and efficiency: AbbVie’s journey of building an integrated nonregulated bioanalytical laboratory

Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of α-methyltyrosine in human plasma

Implications of In Vitro System Conditions for CYP2C9 and CYP3A4: Impact of pH on Clearance and Enzyme Inhibition

High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LCaMS/MS

A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro

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