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Targeting GATA4 for cardiac repair

IUBMB life, 2020-01, Vol.72 (1), p.68-79

2020

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Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4

Scientific reports, 2024-04, Vol.14 (1), p.8938-8938, Article 8938

2024

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Multifunctional 3D‐Printed Patches for Long‐Term Drug Release Therapies after Myocardial Infarction

Advanced functional materials, 2020-08, Vol.30 (34), p.n/a

2020

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Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications

ACS applied materials & interfaces, 2020-02, Vol.12 (6), p.6899-6909

2020

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TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease

Biochimica et biophysica acta. Molecular basis of disease, 2023-06, Vol.1869 (5), p.166689-166689, Article 166689

2023

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Cholecystokinin peptide signaling is regulated by a TBX5-MEF2 axis in the heart

Peptides (New York, N.Y. : 1980), 2021-02, Vol.136, p.170459-170459, Article 170459

2021

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A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior–posterior patterning of the heart

Archives of toxicology, 2020-02, Vol.94 (2), p.631-645

2020

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Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2‑5

Journal of medicinal chemistry, 2017-09, Vol.60 (18), p.7781-7798

2017

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In vitro and in vivo assessment of heart-homing porous silicon nanoparticles

Biomaterials, 2016-07, Vol.94, p.93-104

2016

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In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart

Biomaterials, 2014-09, Vol.35 (29), p.8394-8405

2014

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Abstract 221: Tannic Acid Coated Nanoparticles for Cardiac Regeneration

Circulation research, 2020-07, Vol.127 (Suppl_1)

2020

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SY9-7-3 BNP expression and function in the heart

ENDOCRINE JOURNAL, 2010, Vol.57 (suppl.2-1), p.S273-S273

Heikki J Ruskoaho

2010

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Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018, Vol.WCP2018, p.PO4-2-24

2018

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Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats

Cardiovascular research, 1985-06, Vol.19 (6), p.355-362

1985

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Adrenergic effect on the atrial natriuretic peptide secretion and vasoconstriction induced in the perfused rat heart by phorbol ester

European journal of pharmacology, 1988-04, Vol.148 (3), p.317-325

1988

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Plasma levels of atrial natriuretic peptide during myocardial ischemia induced by percutaneous transluminal coronary angioplasty or dynamic exercise

The American heart journal, 1989, Vol.117 (4), p.837-841

1989

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Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

JACC. Basic to translational science, 2019-02, Vol.4 (1), p.83-94

2019

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Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility

Circulation research, 2002-09, Vol.91 (5), p.434-440

2002

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Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2‑5 Protein–Protein Interaction Modulators

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.8284-8310

2019

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GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

Archives of toxicology, 2020-06, Vol.94 (6), p.2113-2130

2020

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Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound

Stem cell research & therapy, 2024-01, Vol.15 (1), p.5-5, Article 5

2024

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Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

Scientific reports, 2018-03, Vol.8 (1), p.4611-14, Article 4611

2018

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Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

Small (Weinheim an der Bergstrasse, Germany), 2017-09, Vol.13 (33), p.n/a

2017

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The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

PloS one, 2015-06, Vol.10 (6), p.e0130502

2015

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GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line

Stem cell research & therapy, 2021-03, Vol.12 (1), p.190-190, Article 190

2021

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Targeting GATA4 for cardiac repair

Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4

Multifunctional 3D‐Printed Patches for Long‐Term Drug Release Therapies after Myocardial Infarction

Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications

TAF1 bromodomain inhibition as a candidate epigenetic driver of congenital heart disease

Cholecystokinin peptide signaling is regulated by a TBX5-MEF2 axis in the heart

A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior–posterior patterning of the heart

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2‑5

In vitro and in vivo assessment of heart-homing porous silicon nanoparticles

In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart

Abstract 221: Tannic Acid Coated Nanoparticles for Cardiac Regeneration

SY9-7-3 BNP expression and function in the heart

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats

Adrenergic effect on the atrial natriuretic peptide secretion and vasoconstriction induced in the perfused rat heart by phorbol ester

Plasma levels of atrial natriuretic peptide during myocardial ischemia induced by percutaneous transluminal coronary angioplasty or dynamic exercise

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility

Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2‑5 Protein–Protein Interaction Modulators

GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction

Drug‐Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line

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