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Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

Genome research, 2010-08, Vol.20 (8), p.1020

2010

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Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes

Current drug metabolism, 2002-10, Vol.3 (5), p.481

2002

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Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450

Drug metabolism and disposition, 2003-09, Vol.31 (9), p.1161

2003

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Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

Drug metabolism and disposition, 2001-04, Vol.29 (4 Pt 1), p.368

2001

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Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences

Biochemical journal, 2017-10, Vol.474 (20), p.3523-3542

2017

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Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression

Molecular pharmacology, 2004-05, Vol.65 (5), p.1159-1171

2004

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Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450

Drug metabolism and disposition, 2004-03, Vol.32 (3), p.305

2004

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Selective inhibition of dog hepatic CYP2B11 and CYP3A12

The Journal of pharmacology and experimental therapeutics, 2005-05, Vol.313 (2), p.518

2005

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Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1473

2001

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Electrospray Ionization Mass Spectrometric Analysis of Intact Cytochrome P450: Identification of Tienilic Acid Adducts to P450 2C9

Biochemistry (Easton), 1999-02, Vol.38 (8), p.2312-2319

1999

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Halothane-Induced Liver Injury in Outbred Guinea Pigs: Role of Trifluoroacetylated Protein Adducts in Animal Susceptibility

Chemical research in toxicology, 2001-04, Vol.14 (4), p.362-370

2001

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Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences

Current drug metabolism, 2002-06, Vol.3 (3), p.289

2002

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Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection

The Journal of pharmacology and experimental therapeutics, 2004-10, Vol.311 (1), p.307

2004

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Inhibition kinetics of monoclonal antibodies against cytochromes P450

Drug metabolism and disposition, 2002-06, Vol.30 (6), p.701

2002

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A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4

The Journal of biological chemistry, 2001-01, Vol.276 (3), p.2256-2262

2001

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Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity

Drug metabolism and disposition, 2005-07, Vol.33 (7), p.1044

2005

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Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells

Toxicology in vitro, 2011-12, Vol.25 (8), p.2113-2119

2011

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Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.453

2000

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Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

Biochemical journal, 1999-06, Vol.340 ( Pt 3) (3), p.845-853

1999

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Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites

Drug metabolism and disposition, 1999-03, Vol.27 (3), p.365

1999

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Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism

The Journal of pharmacology and experimental therapeutics, 1999-11, Vol.291 (2), p.749

1999

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Mechanism-Based Inactivation of Cytochrome P450 3A4 by L-754,394

Biochemistry (Easton), 2000-04, Vol.39 (15), p.4276-4287

2000

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Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a ( Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse

Journal of pharmacological and toxicological methods, 2006-07, Vol.54 (1), p.78-89

2006

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Towards a systems approach to the human cytochrome P450 ensemble: Interactions between CYP2D6 and CYP2E1 and their functional consequences

Biochemical journal, 2017-10, Vol.474 (20), p.3523-3542

2017

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Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes

Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450

Mapping the genetic architecture of gene expression in human liver

Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences

Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression

Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450

Selective inhibition of dog hepatic CYP2B11 and CYP3A12

Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4

Electrospray Ionization Mass Spectrometric Analysis of Intact Cytochrome P450: Identification of Tienilic Acid Adducts to P450 2C9

Halothane-Induced Liver Injury in Outbred Guinea Pigs: Role of Trifluoroacetylated Protein Adducts in Animal Susceptibility

Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences

Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection

Inhibition kinetics of monoclonal antibodies against cytochromes P450

A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4

Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity

Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells

Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites

Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism

Mechanism-Based Inactivation of Cytochrome P450 3A4 by L-754,394

Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a ( Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse

Towards a systems approach to the human cytochrome P450 ensemble: Interactions between CYP2D6 and CYP2E1 and their functional consequences

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