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The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

Medicinal research reviews, 2018-01, Vol.38 (1), p.147-200

2018

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Efficient, high accuracy ADER-WENO schemes for hydrodynamics and divergence-free magnetohydrodynamics

Journal of computational physics, 2009-04, Vol.228 (7), p.2480-2516

2009

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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Nature communications, 2015-02, Vol.6 (1), p.6263-6263, Article 6263

2015

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Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1599-1612

2016

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Structure-Based Development of an Affinity Probe for Sirtuin 2

Angewandte Chemie (International ed.), 2016-02, Vol.55 (6), p.2252-2256

2016

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New chemical tools for probing activity and inhibition of the NAD + -dependent lysine deacylase sirtuin 2

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2018-06, Vol.373 (1748), p.20170083

2018

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Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

Acta crystallographica. Section F, Structural biology communications, 2015-12, Vol.71 (12), p.1498-1510

2015

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Inhibitors to understand molecular mechanisms of NAD +-dependent deacetylases (sirtuins)

Biochimica et biophysica acta, 2010-10, Vol.1799 (10), p.726-739

2010

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Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 – New Opportunities, New Questions

Chemical record, 2018-12, Vol.18 (12), p.1701-1707

2018

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Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

PloS one, 2012-04, Vol.7 (4), p.e34973

2012

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Strukturbasierte Entwicklung einer Affinitätssonde für Sirtuin 2

Angewandte Chemie, 2016-02, Vol.128 (6), p.2293-2297

2016

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MOF-mediated PRDX1 acetylation regulates LPS-induced macrophage activation

The Journal of immunology (1950), 2023-05, Vol.210 (1_Supplement), p.168-168.06

2023

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MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

Cell reports (Cambridge), 2024-09, Vol.43 (9), p.114682, Article 114682

2024

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Structure-Based Development of an Affinity Probe for Sirtuin2

Angewandte Chemie International Edition, 2016-02, Vol.55 (6), p.2252

International ed. in English, 2016

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Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2582-2597

2019

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Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

Journal of molecular biology, 2014-10, Vol.426 (20), p.3442-3453

2014

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Virtual Screening of PRK1 Inhibitors: Ensemble Docking, Rescoring Using Binding Free Energy Calculation and QSAR Model Development

Journal of chemical information and modeling, 2014-01, Vol.54 (1), p.138-150

2014

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Steroid boost for sirtuin research

Aging (Albany, NY.), 2011-09, Vol.3 (9), p.818-818

2011

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De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

Nature genetics, 2018-10, Vol.50 (10), p.1442-1451

2018

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Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)

Journal of medicinal chemistry, 2010-02, Vol.53 (3), p.1383-1386

2010

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Synthesis and biological activity of splitomicin analogs targeted at human NAD +-dependent histone deacetylases (sirtuins)

Bioorganic & medicinal chemistry, 2011-06, Vol.19 (12), p.3669-3677

2011

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Strukturbasierte Entwicklung einer Affinitätssonde für Sirtuin 2

Angewandte Chemie, 2016-02, Vol.128 (6), p.2293-2297

2016

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Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing

ChemMedChem, 2016-09, Vol.11 (18), p.2084-2094

2016

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Identification of Highly Potent Protein KinaseC-Related Kinase1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and invitro Testing

ChemMedChem, 2016-09, Vol.11 (18), p.2084-2094

2016

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The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

Efficient, high accuracy ADER-WENO schemes for hydrodynamics and divergence-free magnetohydrodynamics

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study

Structure-Based Development of an Affinity Probe for Sirtuin 2

New chemical tools for probing activity and inhibition of the NAD + -dependent lysine deacylase sirtuin 2

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

Inhibitors to understand molecular mechanisms of NAD +-dependent deacetylases (sirtuins)

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 – New Opportunities, New Questions

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

Strukturbasierte Entwicklung einer Affinitätssonde für Sirtuin 2

MOF-mediated PRDX1 acetylation regulates LPS-induced macrophage activation

MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

Structure-Based Development of an Affinity Probe for Sirtuin2

Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases

Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

Virtual Screening of PRK1 Inhibitors: Ensemble Docking, Rescoring Using Binding Free Energy Calculation and QSAR Model Development

Steroid boost for sirtuin research

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)

Synthesis and biological activity of splitomicin analogs targeted at human NAD +-dependent histone deacetylases (sirtuins)

Strukturbasierte Entwicklung einer Affinitätssonde für Sirtuin 2

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing

Identification of Highly Potent Protein KinaseC-Related Kinase1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and invitro Testing

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