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Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

Toxicological sciences, 2002, Vol.65 (1), p.135-150

2002

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Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

ACS medicinal chemistry letters, 2020-09, Vol.11 (9), p.1751-1758

2020

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Discriminating Different Classes of Toxicants by Transcript Profiling

Environmental health perspectives, 2004-08, Vol.112 (12), p.1236-1248

2004

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Metabolomic and Transcriptomic Changes Induced by Overnight (16 h) Fasting in Male and Female Sprague−Dawley Rats

Chemical research in toxicology, 2011-04, Vol.24 (4), p.481-487

2011

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Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

Journal of pharmaceutical and biomedical analysis, 2004-04, Vol.35 (1), p.93-105

2004

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Toxicogenomics in the pharmaceutical industry: Hollow promises or real benefit?

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2005-08, Vol.575 (1), p.102-115

2005

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Survival of Trypanosoma brucei in the tsetse fly is enhanced by the expression of specific forms of procyclin

The Journal of cell biology, 1997-06, Vol.137 (6), p.1369-1379

1997

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Abstract P237: PRT2527 is a potent and selective CDK9 inhibitor that demonstrates anti-cancer activity in preclinical models of hematological malignancies and solid tumors with MYC amplification

Molecular cancer therapeutics, 2021-12, Vol.20 (12_Supplement), p.P237-P237

2021

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PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy

PLoS computational biology, 2007-03, Vol.3 (3), p.389

2007

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Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

The Journal of immunology (1950), 2017-02, Vol.198 (3), p.1308-1319

2017

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Fibromyalgiesyndrom – Bedeutung für die Rehabilitation

Rehabilitation (Stuttgart), 2018-08, Vol.57 (4), p.265-277

2018

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Abstract 5710: The brain penetrant CDK4/6 inhibitor, PRT3645, is highly effective in combination with other targeted therapies in preclinical models of breast cancer, CRC and NSCLC

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.5710-5710

2024

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Biomarker Discovery by Imaging Mass Spectrometry

Molecular & cellular proteomics, 2006-10, Vol.5 (10), p.1876-1886

2006

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Identification of 2‑Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8)

ACS medicinal chemistry letters, 2022-05, Vol.13 (5), p.812-818

2022

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Assessing the risk of drug crystallization in vivo

Journal of pharmacological and toxicological methods, 2019-03, Vol.96, p.1-8

2019

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Discriminating Different Classes of Toxicants by Transcript Profiling

Environmental health perspectives, 2004-08, Vol.112 (12), p.1236-1248

2004

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Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.855-861

2017

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The major cell surface glycoprotein procyclin is a receptor for induction of a novel form of cell death in African trypanosomes in vitro

Molecular and biochemical parasitology, 2000-12, Vol.111 (2), p.333-349

2000

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Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3‑Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.5193-5208

2017

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Abstract 2300: Brain penetrant CDK4/6 inhibitor PRT3645 demonstrates anti-tumor activity and enhances survival in glioblastoma and breast cancer brain metastasis models

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2300-2300

2022

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Abstract 4503: Preclinical characterization of PRT7732: A highly potent, selective, and orally bioavailable targeted protein degrader of SMARCA2

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.4503-4503

2024

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Biomarker discovery by imaging mass spectrometry: transthyretin is a biomarker for gentamicin-induced nephrotoxicity in rat

Molecular & cellular proteomics, 2006-10, Vol.5 (10), p.1876-1886

2006

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Abstract 6277: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6277-6277

2023

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Abstract 5973: The brain penetrant CDK4/6 Inhibitor, PRT3645, is highly effective in combination with other targeted therapies in preclinical models of NSCLC, CRC, and HER2-positive breast cancer

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.5973-5973

2023

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Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (17), p.4256-4260

2016

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Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

Discriminating Different Classes of Toxicants by Transcript Profiling

Metabolomic and Transcriptomic Changes Induced by Overnight (16 h) Fasting in Male and Female Sprague−Dawley Rats

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

Toxicogenomics in the pharmaceutical industry: Hollow promises or real benefit?

Survival of Trypanosoma brucei in the tsetse fly is enhanced by the expression of specific forms of procyclin

Abstract P237: PRT2527 is a potent and selective CDK9 inhibitor that demonstrates anti-cancer activity in preclinical models of hematological malignancies and solid tumors with MYC amplification

PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy

Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

Fibromyalgiesyndrom – Bedeutung für die Rehabilitation

Abstract 5710: The brain penetrant CDK4/6 inhibitor, PRT3645, is highly effective in combination with other targeted therapies in preclinical models of breast cancer, CRC and NSCLC

Biomarker Discovery by Imaging Mass Spectrometry

Identification of 2‑Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8)

Assessing the risk of drug crystallization in vivo

Discriminating Different Classes of Toxicants by Transcript Profiling

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

The major cell surface glycoprotein procyclin is a receptor for induction of a novel form of cell death in African trypanosomes in vitro

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3‑Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders

Abstract 2300: Brain penetrant CDK4/6 inhibitor PRT3645 demonstrates anti-tumor activity and enhances survival in glioblastoma and breast cancer brain metastasis models

Abstract 4503: Preclinical characterization of PRT7732: A highly potent, selective, and orally bioavailable targeted protein degrader of SMARCA2

Biomarker discovery by imaging mass spectrometry: transthyretin is a biomarker for gentamicin-induced nephrotoxicity in rat

Abstract 6277: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor

Abstract 5973: The brain penetrant CDK4/6 Inhibitor, PRT3645, is highly effective in combination with other targeted therapies in preclinical models of NSCLC, CRC, and HER2-positive breast cancer

Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors

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