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GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response

Frontiers in immunology, 2020-06, Vol.11, p.1638-1638

Rudd, Christopher E

2020

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Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy

Cancer research (Chicago, Ill.), 2018-02, Vol.78 (3), p.706-717

2018

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CD28 and CTLA-4 coreceptor expression and signal transduction

Immunological reviews, 2009-05, Vol.229 (1), p.12-26

2009

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Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory

PLoS biology, 2021-05, Vol.19 (5), p.e3001272-e3001272

2021

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CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy

Frontiers in immunology, 2018-11, Vol.9, p.2737-2737

2018

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Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity

Cell reports (Cambridge), 2020-02, Vol.30 (7), p.2075-2082.e4

2020

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Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses

Immunity (Cambridge, Mass.), 2016-02, Vol.44 (2), p.274-286

2016

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Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8 + Cytotoxic T-Cells: Implications for anti-PD-1 Immunotherapy

Frontiers in immunology, 2017-12, Vol.8, p.1653-1653

2017

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CD8+ T cell killing of MHC class I–deficient tumors

Nature cancer, 2023-09, Vol.4 (9), p.1214-1216

Rudd, Christopher E.

2023

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Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report

Frontiers in pharmacology, 2020-12, Vol.11, p.613734-613734

Rudd, Christopher E

2020

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Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells

Scientific reports, 2019-07, Vol.9 (1), p.10462-13, Article 10462

2019

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Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

BMC research notes, 2020-03, Vol.13 (1), p.163-7, Article 163

2020

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GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

Nature communications, 2019-10, Vol.10 (1), p.4804-13, Article 4804

2019

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Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4

Frontiers in immunology, 2014-12, Vol.5, p.619-619

2014

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Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

Scientific reports, 2022-11, Vol.12 (1), p.18509-18509, Article 18509

2022

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Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells

Frontiers in immunology, 2023, Vol.14, p.1192838-1192838

2023

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Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

PloS one, 2021-06, Vol.16 (6), p.e0251731

2021

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Editorial: T-Cell Signaling Networks in Health and Disease

Frontiers in immunology, 2022-04, Vol.13, p.875580-875580

2022

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Reversal of the TCR Stop Signal by CTLA-4

Science (American Association for the Advancement of Science), 2006-09, Vol.313 (5795), p.1972-1975

2006

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In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics

Current issues in molecular biology, 2022-10, Vol.44 (11), p.5312-5351

2022

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LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

Nature communications, 2017-07, Vol.8 (1), p.16001-16001, Article 16001

2017

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The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells

Molecular cell, 2015-09, Vol.59 (5), p.840-849

2015

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SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion

Trends in cell biology, 2008-10, Vol.18 (10), p.486-493

2008

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How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

Frontiers in cell and developmental biology, 2021-03, Vol.9, p.626095

Rudd, Christopher E.

2021

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Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

Frontiers in immunology, 2020-09, Vol.11, p.564499-564499

2020

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GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response

Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy

CD28 and CTLA-4 coreceptor expression and signal transduction

Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory

CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy

Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses

Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8 + Cytotoxic T-Cells: Implications for anti-PD-1 Immunotherapy

CD8+ T cell killing of MHC class I–deficient tumors

Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report

Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells

Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4

Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells

Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

Editorial: T-Cell Signaling Networks in Health and Disease

Reversal of the TCR Stop Signal by CTLA-4

In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells

SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion

How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy

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