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Reprogramming Megakaryocytes for Controlled Release of Platelet-like Particles Carrying a Single-Chain Thromboxane A2 Receptor-G-Protein Complex with Therapeutic Potential

Cells (Basel, Switzerland), 2023-12, Vol.12 (24), p.2775

2023

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A novel single‐chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti‐bleeding functions

Journal of cellular and molecular medicine, 2019-12, Vol.23 (12), p.8343-8354

2019

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Recent advances and near future of insulin production and therapy

Future medicinal chemistry, 2019-07, Vol.11 (13), p.1513-1517

2019

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A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A 2 and exhibiting powerful anti-bleeding functions

Journal of cellular and molecular medicine, 2019-12, Vol.23 (12), p.8343-8354

2019

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Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib

Inflammation research, 2020, Vol.69 (1), p.131-137

2020

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Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage

Scientific reports, 2018-01, Vol.8 (1), p.1653-12, Article 1653

2018

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The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus

Journal of neuroimmune pharmacology, 2020-06, Vol.15 (2), p.292-308

2020

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COX-2-10aa-PGIS Gene Therapy Improves Erectile Function in Rats after Cavernous Nerve Injury

Journal of sexual medicine, 2013-06, Vol.10 (6), p.1476-1487

2013

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Design, synthesis and characterization of lead compounds as anti-inflammatory drugs targeting mPGES-1 via enzymelink screening

Future medicinal chemistry, 2023-05, Vol.15 (9), p.757-767

2023

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Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1

Archives of biochemistry and biophysics, 2016-08, Vol.603, p.29-37

2016

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Recent advances of cannabidiol studies in medicinal chemistry, pharmacology and therapeutics

Future medicinal chemistry, 2021-11, Vol.13 (22), p.1935-1937

2021

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Physical and Functional Antagonism between Tumor Suppressor Protein p53 and Fortilin, an Anti-apoptotic Protein

The Journal of biological chemistry, 2011-09, Vol.286 (37), p.32575-32585

2011

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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells

Journal of cellular physiology, 2012-07, Vol.227 (7), p.2907-2916

2012

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Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy

Cancer research (Chicago, Ill.), 2018-10, Vol.78 (19), p.5656-5667

2018

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Engineering ‘Enzymelink’ for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity

Future medicinal chemistry, 2021-07, Vol.13 (13), p.1091-1103

2021

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Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease

Life sciences (1973), 2011-01, Vol.88 (1-2), p.24-30

2011

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Advance in understanding the biosynthesis of prostacyclin and thromboxane A2 in the endoplasmic reticulum membrane via the cyclooxygenase pathway

Mini reviews in medicinal chemistry, 2004-08, Vol.4 (6), p.639

Ruan, Ke-He

2004

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active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector

The FEBS journal, 2008-12, Vol.275 (23), p.5820-5829

2008

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From the design to the clinical application of thromboxane modulators

Current pharmaceutical design, 2006-03, Vol.12 (8), p.903

2006

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Relationship of the Topological Distances and Activities between mPGES‑1 and COX‑2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX‑1 and COX‑2

Biochemistry (Easton), 2015-06, Vol.54 (23), p.3707-3715

2015

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Assembling NMR structures for the intracellular loops of the human thromboxane A2 receptor: implication of the G protein-coupling pocket

Archives of biochemistry and biophysics, 2008-02, Vol.470 (1), p.73-82

2008

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New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators

Current medicinal chemistry, 2004-05, Vol.11 (10), p.1223

2004

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A New Strategy, SuperEnzyme Gene Therapy in Penile Rehabilitation

Journal of sexual medicine, 2009-03, Vol.6 (S3), p.328-333

2009

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Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs

Current pharmaceutical design, 2006-03, Vol.12 (8), p.925

2006

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How can we target oxidative stress in the treatment of neurodegenerative diseases?

Future medicinal chemistry, 2016-05, Vol.8 (8), p.835-839

2016

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Reprogramming Megakaryocytes for Controlled Release of Platelet-like Particles Carrying a Single-Chain Thromboxane A2 Receptor-G-Protein Complex with Therapeutic Potential

A novel single‐chain enzyme complex with chain reaction properties rapidly producing thromboxane A2 and exhibiting powerful anti‐bleeding functions

Recent advances and near future of insulin production and therapy

A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A 2 and exhibiting powerful anti-bleeding functions

Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib

Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage

The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus

COX-2-10aa-PGIS Gene Therapy Improves Erectile Function in Rats after Cavernous Nerve Injury

Design, synthesis and characterization of lead compounds as anti-inflammatory drugs targeting mPGES-1 via enzymelink screening

Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1

Recent advances of cannabidiol studies in medicinal chemistry, pharmacology and therapeutics

Physical and Functional Antagonism between Tumor Suppressor Protein p53 and Fortilin, an Anti-apoptotic Protein

Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells

Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy

Engineering ‘Enzymelink’ for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity

Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease

Advance in understanding the biosynthesis of prostacyclin and thromboxane A2 in the endoplasmic reticulum membrane via the cyclooxygenase pathway

active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector

From the design to the clinical application of thromboxane modulators

Relationship of the Topological Distances and Activities between mPGES‑1 and COX‑2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX‑1 and COX‑2

Assembling NMR structures for the intracellular loops of the human thromboxane A2 receptor: implication of the G protein-coupling pocket

New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators

A New Strategy, SuperEnzyme Gene Therapy in Penile Rehabilitation

Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs

How can we target oxidative stress in the treatment of neurodegenerative diseases?

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