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Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway

Critical reviews in eukaryotic gene expression, 2012, Vol.22 (1), p.61

Rowe, Peter S N

2012

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Degradation of MEPE, DMP1, and Release of SIBLING ASARM-Peptides (Minhibins): ASARM-Peptide(s) Are Directly Responsible for Defective Mineralization in HYP

Endocrinology (Philadelphia), 2008-04, Vol.149 (4), p.1757-1772

2008

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Matrix Extracellular Phosphoglycoprotein (MEPE) Is a New Bone Renal Hormone and Vascularization Modulator

Endocrinology (Philadelphia), 2009-09, Vol.150 (9), p.4012-4023

2009

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PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism

PloS one, 2014-05, Vol.9 (5), p.e97326

2014

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MEPE’s Diverse Effects on Mineralization

Calcified tissue international, 2010-01, Vol.86 (1), p.42-46

2010

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Phosphorylated acidic serine–aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

Journal of endocrinology, 2007-01, Vol.192 (1), p.261-267

2007

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The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled

Cell biochemistry and function, 2012-07, Vol.30 (5), p.355-375

Rowe, Peter S. N.

2012

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MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1

Nucleic acids research, 2009-12, Vol.37 (22), p.7447

2009

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Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

Bone (New York, N.Y.), 2006-10, Vol.39 (4), p.773-786

2006

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Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif

Bone (New York, N.Y.), 2015-10, Vol.79, p.131-142

2015

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ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate

American Journal of Physiology - Renal Physiology, 2011-03, Vol.300 (3), p.F783-F791

2011

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Do ASARM peptides play a role in nephrogenic systemic fibrosis?

American journal of physiology. Renal physiology, 2015-11, Vol.309 (9), p.F764-F769

2015

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Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE–ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)

Bone (New York, N.Y.), 2005-01, Vol.36 (1), p.33-46

2005

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Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets

Journal of endocrinology, 2004-12, Vol.183 (3), p.R1-R9

2004

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SPR4-peptide alters bone metabolism of normal and HYP mice

Bone (New York, N.Y.), 2015-03, Vol.72, p.23-33

2015

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Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

The Journal of clinical investigation, 2020-04, Vol.130 (4), p.1948-1960

2020

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A unified model for bone–renal mineral and energy metabolism

Current opinion in pharmacology, 2015-06, Vol.22, p.64-71

Rowe, Peter S

2015

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Comprehensive phenotyping of cutaneous afferents reveals early-onset alterations in nociceptor response properties, release of CGRP, and hindpaw edema following spinal cord injury

Neurobiology of pain, 2022-08, Vol.12, p.100097-100097, Article 100097

2022

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The wrickkened pathways of FGF23, MEPE and PHEX

Critical reviews in oral biology and medicine, 2004-09, Vol.15 (5), p.264-281

Rowe, Peter S N

2004

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Inhibition of MEPE cleavage by Phex

Biochemical and biophysical research communications, 2002-09, Vol.297 (1), p.38-45

2002

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X-linked rickets and tumor-acquired osteomalacia:PHEX and the missing link

Clinical and experimental nephrology, 1998-09, Vol.2 (3), p.183-193

Rowe, Peter S. N.

1998

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ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate

American journal of physiology. Renal physiology, 2011, Vol.69 (3)

2011

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A PHEX Gene Mutation Is Responsible for Adult-Onset Vitamin D-Resistant Hypophosphatemic Osteomalacia: Evidence That the Disorder Is Not a Distinct Entity from X-Linked Hypophosphatemic Rickets1

The journal of clinical endocrinology and metabolism, 1998-10, Vol.83 (10), p.3459-3462

1998

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Distribution of Mutations in the PEX Gene in Families with X-linked Hypophosphataemic Rickets (HYP)

Human molecular genetics, 1997-04, Vol.6 (4), p.539-549

1997

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Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin

Protein engineering, 2002-03, Vol.15 (3), p.205-214

2002

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Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway

Degradation of MEPE, DMP1, and Release of SIBLING ASARM-Peptides (Minhibins): ASARM-Peptide(s) Are Directly Responsible for Defective Mineralization in HYP

Matrix Extracellular Phosphoglycoprotein (MEPE) Is a New Bone Renal Hormone and Vascularization Modulator

PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism

MEPE’s Diverse Effects on Mineralization

Phosphorylated acidic serine–aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled

MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1

Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif

ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate

Do ASARM peptides play a role in nephrogenic systemic fibrosis?

Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE–ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)

Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets

SPR4-peptide alters bone metabolism of normal and HYP mice

Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

A unified model for bone–renal mineral and energy metabolism

Comprehensive phenotyping of cutaneous afferents reveals early-onset alterations in nociceptor response properties, release of CGRP, and hindpaw edema following spinal cord injury

The wrickkened pathways of FGF23, MEPE and PHEX

Inhibition of MEPE cleavage by Phex

X-linked rickets and tumor-acquired osteomalacia:PHEX and the missing link

ASARM peptides: PHEX-dependent and -independent regulation of serum phosphate

A PHEX Gene Mutation Is Responsible for Adult-Onset Vitamin D-Resistant Hypophosphatemic Osteomalacia: Evidence That the Disorder Is Not a Distinct Entity from X-Linked Hypophosphatemic Rickets1

Distribution of Mutations in the PEX Gene in Families with X-linked Hypophosphataemic Rickets (HYP)

Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin

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