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Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus

Biochemistry (Easton), 2007-07, Vol.46 (30), p.8744-8752

2007

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Synthesis of the C(29)−C(45) Bis-pyran Subunit (E−F) of Spongistatin 1 (Altohyrtin A)

Journal of organic chemistry, 2000-12, Vol.65 (25), p.8730-8736

2000

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Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones

Antimicrobial Agents and Chemotherapy, 2003-01, Vol.47 (1), p.154-160

2003

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Studies on the Synthesis of Landomycin A: Synthesis and Glycosidation Reactions of l-Rhodinosyl Acetate Derivatives

Journal of organic chemistry, 2001-09, Vol.66 (19), p.6389-6393

2001

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Cathepsins X and B Can Be Differentiated through Their Respective Mono- and Dipeptidyl Carboxypeptidase Activities

Biochemistry (Easton), 2001-03, Vol.40 (9), p.2702-2711

2001

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Cathepsins X and B Display Distinct Activity Profiles That Can Be Exploited for Inhibitor Design

Biological chemistry, 2001-05, Vol.382 (5), p.839-845

2001

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Targeting the NLRP3 inflammasome in inflammatory diseases

Nature reviews. Drug discovery, 2018-08, Vol.17 (8), p.588-606

2018

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Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases

Journal of the American Chemical Society, 1998-10, Vol.120 (42), p.10994-10995

1998

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Recent advances in the synthesis, design and selection of cysteine protease inhibitors

Current Opinion in Chemical Biology, 2002-08, Vol.6 (4), p.459-465

2002

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Design and synthesis of dipeptidyl α′,β′-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2809-2812

1998

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Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

Molecular and biochemical parasitology, 2001-11, Vol.118 (1), p.61-73

2001

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A target within the target: probing cruzain’s P1′ site to define structural determinants for the Chagas’ disease protease

Structure (London), 2000-08, Vol.8 (8), p.831-840

2000

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Use of Thallium(I) Ethoxide in Suzuki Cross Coupling Reactions

Organic letters, 2000-08, Vol.2 (17), p.2691-2694

2000

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Studies on the Synthesis of 2,6-Disubstituted Dihydropyrans: Intervention of Oxonia-Cope Rearrangements in the Lewis Acid Mediated Cyclodehydrative Reactions of Aldehydes and β-Hydroxyallylsilanes

Synlett, 2001, Vol.2001 (Special Issue), p.0955-0959

2001

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Studies on the Synthesis of Pectenotoxin II: Synthesis of a C(11)−C(26) Fragment Precursor via [3 + 2]-Annulation Reactions of Chiral Allylsilanes

Organic letters, 2001-06, Vol.3 (12), p.1949-1952

2001

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Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (20), p.2759-2762

2001

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A Three-Component Coupling Strategy for Tetrahydrofuran Synthesis: Application of the Diisopropyl Tartrate Modified (E)-γ-(Dimethylphenylsilyl)allylboronate as an α,γ-Allyl Dianion Equivalent

Organic letters, 2000-02, Vol.2 (4), p.461-464

2000

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Concerning the diastereofacial selectivity of the aldol reactions of .alpha.-methyl chiral aldehydes and lithium and boron propionate enolates

Journal of organic chemistry, 1991-06, Vol.56 (13), p.4151-4157

Roush, William R

1991

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Nucleophilic Phosphine Organocatalysis

Advanced synthesis & catalysis, 2004-08, Vol.346 (9-10), p.1035-1050

2004

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CDK12/13 Inhibitor SR-4835 Is Active in Triple-Negative Breast Cancer

Cancer discovery, 2019-12, Vol.9 (12), p.1644-1644

2019

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2-Deoxy-2-iodo-α-mannopyranosyl and -talopyranosyl Acetates: Highly Stereoselective Glycosyl Donors for the Synthesis of 2-Deoxy-α-glycosides

Organic letters, 1999-09, Vol.1 (6), p.899-902

1999

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2-Deoxy-2-iodo- and 2-Deoxy-2-bromo-α-glucopyranosyl Trichloroacetimidates: Highly Reactive and Stereoselective Donors for the Synthesis of 2-Deoxy-β-glycosides

Organic letters, 1999-09, Vol.1 (6), p.891-893

1999

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Studies on the Synthesis of Tedanolide: Synthesis of the C(5)−C(21) Segment via a Highly Stereoselective Fragment Assembly Aldol Reaction of a Chiral β,γ-Unsaturated Methyl Ketone

Organic letters, 1999-07, Vol.1 (1), p.95-98

1999

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Total synthesis of mycalamide A and 7-epi-mycalamide A

Organic letters, 2000-03, Vol.2 (6), p.859

2000

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Acyclic diastereoselective synthesis using tartrate ester-modified crotylboronates. Double asymmetric reactions with .alpha.-methyl chiral aldehydes and synthesis of the C(19)-C(29) segment of rifamycin S

Journal of the American Chemical Society, 1990-08, Vol.112 (17), p.6348-6359

1990

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Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus

Synthesis of the C(29)−C(45) Bis-pyran Subunit (E−F) of Spongistatin 1 (Altohyrtin A)

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones

Studies on the Synthesis of Landomycin A: Synthesis and Glycosidation Reactions of l-Rhodinosyl Acetate Derivatives

Cathepsins X and B Can Be Differentiated through Their Respective Mono- and Dipeptidyl Carboxypeptidase Activities

Cathepsins X and B Display Distinct Activity Profiles That Can Be Exploited for Inhibitor Design

Targeting the NLRP3 inflammasome in inflammatory diseases

Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases

Recent advances in the synthesis, design and selection of cysteine protease inhibitors

Design and synthesis of dipeptidyl α′,β′-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

A target within the target: probing cruzain’s P1′ site to define structural determinants for the Chagas’ disease protease

Use of Thallium(I) Ethoxide in Suzuki Cross Coupling Reactions

Studies on the Synthesis of 2,6-Disubstituted Dihydropyrans: Intervention of Oxonia-Cope Rearrangements in the Lewis Acid Mediated Cyclodehydrative Reactions of Aldehydes and β-Hydroxyallylsilanes

Studies on the Synthesis of Pectenotoxin II: Synthesis of a C(11)−C(26) Fragment Precursor via [3 + 2]-Annulation Reactions of Chiral Allylsilanes

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain

A Three-Component Coupling Strategy for Tetrahydrofuran Synthesis: Application of the Diisopropyl Tartrate Modified (E)-γ-(Dimethylphenylsilyl)allylboronate as an α,γ-Allyl Dianion Equivalent

Concerning the diastereofacial selectivity of the aldol reactions of .alpha.-methyl chiral aldehydes and lithium and boron propionate enolates

Nucleophilic Phosphine Organocatalysis

CDK12/13 Inhibitor SR-4835 Is Active in Triple-Negative Breast Cancer

2-Deoxy-2-iodo-α-mannopyranosyl and -talopyranosyl Acetates: Highly Stereoselective Glycosyl Donors for the Synthesis of 2-Deoxy-α-glycosides

2-Deoxy-2-iodo- and 2-Deoxy-2-bromo-α-glucopyranosyl Trichloroacetimidates: Highly Reactive and Stereoselective Donors for the Synthesis of 2-Deoxy-β-glycosides

Studies on the Synthesis of Tedanolide: Synthesis of the C(5)−C(21) Segment via a Highly Stereoselective Fragment Assembly Aldol Reaction of a Chiral β,γ-Unsaturated Methyl Ketone

Total synthesis of mycalamide A and 7-epi-mycalamide A

Acyclic diastereoselective synthesis using tartrate ester-modified crotylboronates. Double asymmetric reactions with .alpha.-methyl chiral aldehydes and synthesis of the C(19)-C(29) segment of rifamycin S

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