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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

British journal of pharmacology, 2014-07, Vol.171 (14), p.3364-3375

2014

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Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1674-1676

2010

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Stereoisomers of ketoconazole: preparation and biological activity

Journal of medicinal chemistry, 1992-07, Vol.35 (15), p.2818-2825

1992

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Spiropiperidine CCR5 antagonists

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5401-5406

2009

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Synthesis, SAR and evaluation of [1,4′]-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3219-3222

2010

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Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.209-213

2009

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Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1830-1833

2010

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Exploration of a new series of CCR5 antagonists: Multi-dimensional optimization of a sub-series containing N-substituted pyrazoles

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4753-4756

2010

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Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6802-6807

2010

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Novel hexahydropyrrolo[3,4- c]pyrrole CCR5 antagonists

Bioorganic & medicinal chemistry letters, 2010-05, Vol.20 (10), p.3116-3119

2010

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR 5 receptor small molecule allosteric ligands

British journal of pharmacology, 2014-07, Vol.171 (14), p.3364-3375

2014

Volltextzugriff (PDF)

Practical and divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones

Tetrahedron letters, 2008-10, Vol.49 (44), p.6371-6374

2008

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Selective inhibition of mammalian lanosterol 14.alpha.-demethylase: a possible strategy for cholesterol lowering

Journal of medicinal chemistry, 1993-07, Vol.36 (15), p.2235-2237

1993

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A new synthesis of novel 2-substituted derivatives of the anhydro-3-hydroxythiazolo[3,2-a]pyridinium hydroxide inner salt ring system

Journal of organic chemistry, 1982-03, Vol.47 (6), p.1136-1138

1982

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Selective inhibition of mammalian lanosterol 14α-demethylase : a possible strategy for cholesterol lowering

Journal of medicinal chemistry, 1993-07, Vol.36 (15), p.2235-2237

1993

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The synthesis and antifungal activity of the enantiomers of butoconazole nitrate

Tetrahedron: asymmetry, 1993-07, Vol.4 (7), p.1521-1526

1993

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New Approaches to the Preparation of 1-Substituted 1,3-Dihydroimidazole-2-thione Derivatives: Thionation of Imidazoles1

Synlett, 1995-06, Vol.1995 (6), p.655-658

1995

Volltextzugriff (PDF)

ChemInform Abstract: Practical and Divergent Synthesis of 1- and 5-Substituted 3,9-Diazaspiro[5.5]undecanes and undecan-2-ones

ChemInform, 2009-02, Vol.40 (7), p.no-no

2009

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Micafungin versus Caspofungin for Treatment of Candidemia and Other Forms of Invasive Candidiasis

Clinical infectious diseases, 2007-10, Vol.45 (7), p.883-893

2007

Volltextzugriff (PDF)

Clinical Safety of Renaming Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: Is NIFTP Truly Benign?

World journal of surgery, 2018-02, Vol.42 (2), p.321-326

2018

Volltextzugriff (PDF)

Pathology findings and correlation with body condition index in stranded killer whales (Orcinus orca) in the northeastern Pacific and Hawaii from 2004 to 2013

PloS one, 2020-12, Vol.15 (12), p.e0242505-e0242505

2020

Volltextzugriff (PDF)

Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity

Cardiovascular research, 2024-02, Vol.119 (18), p.2858-2874

2024

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Mechanisms of generation of membrane potential resonance in a neuron with multiple resonant ionic currents

PLoS computational biology, 2017-06, Vol.13 (6), p.e1005565-e1005565

2017

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Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder

Brain and behavior, 2019-05, Vol.9 (5), p.e01275-n/a

2019

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc

Stereoisomers of ketoconazole: preparation and biological activity

Spiropiperidine CCR5 antagonists

Synthesis, SAR and evaluation of [1,4′]-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists

Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist

Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists

Exploration of a new series of CCR5 antagonists: Multi-dimensional optimization of a sub-series containing N-substituted pyrazoles

Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series

Novel hexahydropyrrolo[3,4- c]pyrrole CCR5 antagonists

A study of the molecular mechanism of binding kinetics and long residence times of human CCR 5 receptor small molecule allosteric ligands

Practical and divergent synthesis of 1- and 5-substituted 3,9-diazaspiro[5.5]undecanes and undecan-2-ones

Selective inhibition of mammalian lanosterol 14.alpha.-demethylase: a possible strategy for cholesterol lowering

A new synthesis of novel 2-substituted derivatives of the anhydro-3-hydroxythiazolo[3,2-a]pyridinium hydroxide inner salt ring system

Selective inhibition of mammalian lanosterol 14α-demethylase : a possible strategy for cholesterol lowering

The synthesis and antifungal activity of the enantiomers of butoconazole nitrate

New Approaches to the Preparation of 1-Substituted 1,3-Dihydroimidazole-2-thione Derivatives: Thionation of Imidazoles1

ChemInform Abstract: Practical and Divergent Synthesis of 1- and 5-Substituted 3,9-Diazaspiro[5.5]undecanes and undecan-2-ones

Micafungin versus Caspofungin for Treatment of Candidemia and Other Forms of Invasive Candidiasis

Clinical Safety of Renaming Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: Is NIFTP Truly Benign?

Pathology findings and correlation with body condition index in stranded killer whales (Orcinus orca) in the northeastern Pacific and Hawaii from 2004 to 2013

Outbreak of hepatitis A in the USA associated with frozen pomegranate arils imported from Turkey: an epidemiological case study

Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity

Mechanisms of generation of membrane potential resonance in a neuron with multiple resonant ionic currents

Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder

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