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Do amyloid fibrils induce inflammation, or does inflammation generate amyloid fibrils?

Proceedings of the National Academy of Sciences - PNAS, 2022-10, Vol.119 (40), p.e2213903119-e2213903119

Rothbard, Jonathan B

2022

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Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (27), p.7081-7086

2018

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Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation

Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (32), p.13287-13292

2011

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Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease

Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (49), p.15016-15023

2015

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Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation

Science translational medicine, 2013-04, Vol.5 (179), p.179ra42

2013

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Role of Membrane Potential and Hydrogen Bonding in the Mechanism of Translocation of Guanidinium-Rich Peptides into Cells

Journal of the American Chemical Society, 2004-08, Vol.126 (31), p.9506-9507

2004

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Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies

Cold Spring Harbor perspectives in medicine, 2019-07, Vol.9 (7), p.a034223

2019

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Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells

Advanced drug delivery reviews, 2005-02, Vol.57 (4), p.495-504

2005

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Arginine-Rich Molecular Transporters for Drug Delivery: Role of Backbone Spacing in Cellular Uptake

Journal of medicinal chemistry, 2002-08, Vol.45 (17), p.3612-3618

2002

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Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

Nature medicine, 2000-11, Vol.6 (11), p.1253-1257

2000

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Chaperone Activity of Small Heat Shock Proteins Underlies Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis

The Journal of biological chemistry, 2012-10, Vol.287 (43), p.36423-36434

2012

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Therapeutic Effects of Systemic Administration of Chaperone αB-Crystallin Associated with Binding Proinflammatory Plasma Proteins

The Journal of biological chemistry, 2012-03, Vol.287 (13), p.9708-9721

2012

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Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease

The Journal of experimental medicine, 2014-08, Vol.211 (9), p.1847-1856

2014

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Janus Faces of Amyloid Proteins in Neuroinflammation

Journal of clinical immunology, 2014-07, Vol.34 (Suppl 1), p.61-63

2014

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Genetic Background Modulates Outcome of Therapeutic Amyloid Peptides in Treatment of Neuroinflammation

Journal of neuroimmunology, 2016-09, Vol.298, p.42-50

2016

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Oligocarbamate Molecular Transporters: Design, Synthesis, and Biological Evaluation of a New Class of Transporters for Drug Delivery

Journal of the American Chemical Society, 2002-11, Vol.124 (45), p.13382-13383

2002

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An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis

PloS one, 2018-07, Vol.13 (7), p.e0199206-e0199206

2018

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Releasable Luciferin−Transporter Conjugates: Tools for the Real-Time Analysis of Cellular Uptake and Release

Journal of the American Chemical Society, 2006-05, Vol.128 (20), p.6526-6527

2006

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Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10340-10345

2007

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Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real-Time Imaging

Chembiochem : a European journal of chemical biology, 2006-10, Vol.7 (10), p.1497-1515

2006

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The Design, Synthesis, and Evaluation of Molecules That Enable or Enhance Cellular Uptake: Peptoid Molecular Transporters

Proceedings of the National Academy of Sciences - PNAS, 2000-11, Vol.97 (24), p.13003-13008

2000

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Response to Comment on “Chaperone Activity of α B-Crystallin Is Responsible for Its Incorrect Assignment as an Autoantigen in Multiple Sclerosis”

The Journal of immunology (1950), 2011-07, Vol.187 (1), p.3-4

2011

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Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis

The Journal of immunology (1950), 2011-04, Vol.186 (7), p.4263-4268

2011

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αB-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion

The Annals of thoracic surgery, 2011-06, Vol.91 (6), p.1907-1913

2011

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Self-Assembling Peptides Form Immune Suppressive Amyloid Fibrils Effective in Autoimmune Encephalomyelitis

Current topics in behavioral neurosciences, 2015-01, Vol.26, p.221

2015

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Do amyloid fibrils induce inflammation, or does inflammation generate amyloid fibrils?

Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine

Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation

Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease

Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation

Role of Membrane Potential and Hydrogen Bonding in the Mechanism of Translocation of Guanidinium-Rich Peptides into Cells

Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies

Adaptive translocation: the role of hydrogen bonding and membrane potential in the uptake of guanidinium-rich transporters into cells

Arginine-Rich Molecular Transporters for Drug Delivery: Role of Backbone Spacing in Cellular Uptake

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation

Chaperone Activity of Small Heat Shock Proteins Underlies Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis

Therapeutic Effects of Systemic Administration of Chaperone αB-Crystallin Associated with Binding Proinflammatory Plasma Proteins

Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease

Janus Faces of Amyloid Proteins in Neuroinflammation

Genetic Background Modulates Outcome of Therapeutic Amyloid Peptides in Treatment of Neuroinflammation

Oligocarbamate Molecular Transporters: Design, Synthesis, and Biological Evaluation of a New Class of Transporters for Drug Delivery

An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis

Releasable Luciferin−Transporter Conjugates: Tools for the Real-Time Analysis of Cellular Uptake and Release

Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice

Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real-Time Imaging

The Design, Synthesis, and Evaluation of Molecules That Enable or Enhance Cellular Uptake: Peptoid Molecular Transporters

Response to Comment on “Chaperone Activity of α B-Crystallin Is Responsible for Its Incorrect Assignment as an Autoantigen in Multiple Sclerosis”

Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis

αB-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion

Self-Assembling Peptides Form Immune Suppressive Amyloid Fibrils Effective in Autoimmune Encephalomyelitis

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