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Amylin: Pharmacology, Physiology, and Clinical Potential

Pharmacological reviews, 2015-07, Vol.67 (3), p.564-600

2015

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Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

American journal of physiology: Gastrointestinal and liver physiology, 2013-10, Vol.305 (7), p.G483-G495

2013

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FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

Journal of lipid research, 2018-06, Vol.59 (6), p.982-993

2018

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Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice

American journal of physiology: Gastrointestinal and liver physiology, 2012-04, Vol.302 (8), p.G762-G772

2012

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Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (20), p.7257-7262

2008

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Mechanisms of Amylin/Leptin Synergy in Rodent Models

Endocrinology (Philadelphia), 2010-01, Vol.151 (1), p.143-152

2010

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Effects of amylin and bupropion/naltrexone on food intake and body weight are interactive in rodent models

European journal of pharmacology, 2013-01, Vol.698 (1-3), p.292-298

2013

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Amylin and the regulation of appetite and adiposity: recent advances in receptor signaling, neurobiology and pharmacology

Current opinion in endocrinology, diabetes, and obesity, 2013-02, Vol.20 (1), p.8-13

Roth, Jonathan D

2013

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Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

Scientific reports, 2019-06, Vol.9 (1), p.9046-13, Article 9046

2019

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GLP‐1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities

British journal of pharmacology, 2012-05, Vol.166 (1), p.121-136

2012

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Antiobesity Effects of the β-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression

Endocrinology (Philadelphia), 2006-12, Vol.147 (12), p.5855-5864

2006

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Insights into amylin–leptin synergy

Trends in endocrinology and metabolism, 2010-08, Vol.21 (8), p.473-479

2010

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Interaction of Leptin and Amylin in the Long-term Maintenance of Weight Loss in Diet-induced Obese Rats

Obesity (Silver Spring, Md.), 2010-01, Vol.18 (1), p.21-26

2010

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Simultaneous quantification of the glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) receptor agonists in rodent plasma by on-line solid phase extraction and LC–MS/MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014-04, Vol.957, p.24-29

2014

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Noradrenergic neurons of the area postrema mediate amylin's hypophagic action

American journal of physiology. Regulatory, integrative and comparative physiology, 2010-08, Vol.299 (2), p.R623-R631

2010

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Enhanced Amylin-Mediated Body Weight Loss in Estradiol-Deficient Diet-Induced Obese Rats

Endocrinology (Philadelphia), 2010-12, Vol.151 (12), p.5657-5668

2010

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“Weighing in” on synergy: Preclinical research on neurohormonal anti-obesity combinations

Brain research, 2010-09, Vol.1350, p.86-94

2010

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Combination Therapy with Amylin and Peptide YY[3–36] in Obese Rodents: Anorexigenic Synergy and Weight Loss Additivity

Endocrinology (Philadelphia), 2007-12, Vol.148 (12), p.6054-6061

2007

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Multi-hormonal weight loss combinations in diet-induced obese rats: Therapeutic potential of cholecystokinin?

Physiology & behavior, 2010-05, Vol.100 (2), p.187-195

2010

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It Takes Two to Tango: Combined Amylin/Leptin Agonism as a Potential Approach to Obesity Drug Development

Journal of investigative medicine, 2009-10, Vol.57 (7), p.777-783

2009

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Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus

Brain research, 2003-10, Vol.986 (1), p.1-11

2003

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Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats

American journal of physiology: endocrinology and metabolism, 2007-10, Vol.293 (4), p.E1112-E1117

2007

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Hormone-based therapies in the regulation of fuel metabolism and body weight

Expert opinion on biological therapy, 2008-11, Vol.8 (11), p.1733-1747

2008

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Role of islet-, gut-, and adipocyte-derived hormones in the central control of food intake and body weight: implications for an integrated neurohormonal approach to obesity pharmacotherapy

Current diabetes reviews, 2008-05, Vol.4 (2), p.79

2008

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It Takes Two to Tango

Journal of investigative medicine, 2009-10, Vol.57 (7), p.777

2009

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Amylin: Pharmacology, Physiology, and Clinical Potential

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

Mechanisms of Amylin/Leptin Synergy in Rodent Models

Effects of amylin and bupropion/naltrexone on food intake and body weight are interactive in rodent models

Amylin and the regulation of appetite and adiposity: recent advances in receptor signaling, neurobiology and pharmacology

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

GLP‐1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities

Antiobesity Effects of the β-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression

Insights into amylin–leptin synergy

Interaction of Leptin and Amylin in the Long-term Maintenance of Weight Loss in Diet-induced Obese Rats

Simultaneous quantification of the glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) receptor agonists in rodent plasma by on-line solid phase extraction and LC–MS/MS

Noradrenergic neurons of the area postrema mediate amylin's hypophagic action

Enhanced Amylin-Mediated Body Weight Loss in Estradiol-Deficient Diet-Induced Obese Rats

“Weighing in” on synergy: Preclinical research on neurohormonal anti-obesity combinations

Combination Therapy with Amylin and Peptide YY[3–36] in Obese Rodents: Anorexigenic Synergy and Weight Loss Additivity

Multi-hormonal weight loss combinations in diet-induced obese rats: Therapeutic potential of cholecystokinin?

It Takes Two to Tango: Combined Amylin/Leptin Agonism as a Potential Approach to Obesity Drug Development

Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus

Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats

Hormone-based therapies in the regulation of fuel metabolism and body weight

Role of islet-, gut-, and adipocyte-derived hormones in the central control of food intake and body weight: implications for an integrated neurohormonal approach to obesity pharmacotherapy

It Takes Two to Tango

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