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Suppression of Parvalbumin Interneuron Activity in the Prefrontal Cortex Recapitulates Features of Impaired Excitatory/Inhibitory Balance and Sensory Processing in Schizophrenia

Schizophrenia bulletin, 2020-07, Vol.46 (4), p.981-989

2020

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Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders

Neuropsychopharmacology (New York, N.Y.), 2021-07, Vol.46 (8), p.1526-1534

2021

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Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice

Translational psychiatry, 2023-05, Vol.13 (1), p.150-150, Article 150

2023

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Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning

Frontiers in pharmacology, 2024-07, Vol.15, p.1412725

2024

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Quantitative electroencephalography parameters as neurophysiological biomarkers of schizophrenia-related deficits: A Phase II substudy of patients treated with iclepertin (BI 425809)

Translational psychiatry, 2022-08, Vol.12 (1), p.329-329, Article 329

2022

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A comprehensive analysis of auditory event‐related potentials and network oscillations in an NMDA receptor antagonist mouse model using a novel wireless recording technology

Physiological reports, 2018-08, Vol.6 (16), p.e13782-n/a

2018

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Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia

European archives of psychiatry and clinical neuroscience, 2023-10, Vol.273 (7), p.1557-1566

2023

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Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

European journal of pharmacology, 2010-08, Vol.639 (1), p.40-46

2010

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The Selective mGlu5 Receptor Antagonist MTEP, Similar to NMDA Receptor Antagonists, Induces Social Isolation in Rats

Neuropsychopharmacology (New York, N.Y.), 2007-03, Vol.32 (3), p.562-576

2007

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Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats

Brain research, 2005-04, Vol.1040 (1), p.55-63

2005

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The Glycine Transport Inhibitor Bi 425809 Restores Translatable EEG Deficits in an Acute Mouse Model for Schizophrenia-Related Sensory Processing and Cortical Network Dysfunction

Biological psychiatry (1969), 2021-05, Vol.89 (9), p.S199-S200

2021

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S25. EFFECTS OF METABOTROPIC GLUTAMATE 2/3 RECEPTOR ACTIVATION ON DEFICITS OF NEURAL NETWORK FUNCTION INDUCED BY OPTOGENETIC INHIBITION OF PARVALBUMIN-POSITIVE INTERNEURONS IN THE MOUSE PREFRONTAL CORTEX

Schizophrenia bulletin, 2019-04, Vol.45 (Supplement_2), p.S315-S315

2019

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Neuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia

Biological psychiatry (1969), 2024-10, Vol.96 (8), p.666-673

2024

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Effects of the Glycine Transporter-1 Inhibitor Iclepertin (BI 425809) on Sensory Processing, Neural Network Function, and Cognition in Animal Models Related to Schizophrenia

The Journal of pharmacology and experimental therapeutics, 2022-08, Vol.382 (2), p.223-232

2022

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SA11. Analysis of Auditory Event-Related Potentials and Oscillation in a Mouse Model Related to Schizophrenia by a Novel Technology for Wireless Recording

Schizophrenia bulletin, 2017-03, Vol.43 (suppl_1), p.S116-S117

2017

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Reply to the Letter to the Editor regarding; Not mismatch negativity modulation of sensory N1 is measured

Neuroscience, 2023-02, Vol.512, p.135-135

2023

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Inhibition of cGMP-metabolizing PDEs as target for cognitive enhancement

BMC pharmacology & toxicology, 2015-09, Vol.16 (S1), p.A19-A19, Article A19

Rosenbrock, Holger

2015

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P376. Preclinical Pharmacological Characterization of the Selective NR2b Negative Allosteric Modulator BI 1569912 With Potential to Treat MDD

Biological psychiatry (1969), 2022-05, Vol.91 (9), p.S239-S239

2022

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Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents

European journal of pharmacology, 2022-11, Vol.935, p.175306-175306, Article 175306

2022

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Increasing the Excitatory Drive Rescues Excitatory/Inhibitory Imbalance and Mismatch Negativity Deficit Caused by Parvalbumin Specific GluA1 Deletion

Neuroscience, 2022-08, Vol.496, p.190-204

2022

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Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders

Brain, behavior, and immunity, 2020-08, Vol.88, p.461-470

2020

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Electroencephalography as a Clinical Biomarker in a Phase II Substudy With BI 425809 in Patients With Schizophrenia

Biological psychiatry (1969), 2021-05, Vol.89 (9), p.S147-S147

2021

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Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies

British journal of clinical pharmacology, 2024-10, Vol.90 (10), p.2517-2528

2024

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Effects of mGlu2/3 Receptor Activation on Neural Network and Single Neuron Function in a Prefrontal Cortex Optogenetic Model of E/I Imbalance

Biological psychiatry (1969), 2020-05, Vol.87 (9), p.S280-S281

2020

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Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase‐1 improves cognitive performance

British journal of pharmacology, 2018-07, Vol.175 (14), p.3021-3033

2018

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Suppression of Parvalbumin Interneuron Activity in the Prefrontal Cortex Recapitulates Features of Impaired Excitatory/Inhibitory Balance and Sensory Processing in Schizophrenia

Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders

Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice

Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning

Quantitative electroencephalography parameters as neurophysiological biomarkers of schizophrenia-related deficits: A Phase II substudy of patients treated with iclepertin (BI 425809)

A comprehensive analysis of auditory event‐related potentials and network oscillations in an NMDA receptor antagonist mouse model using a novel wireless recording technology

Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

The Selective mGlu5 Receptor Antagonist MTEP, Similar to NMDA Receptor Antagonists, Induces Social Isolation in Rats

Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats

The Glycine Transport Inhibitor Bi 425809 Restores Translatable EEG Deficits in an Acute Mouse Model for Schizophrenia-Related Sensory Processing and Cortical Network Dysfunction

S25. EFFECTS OF METABOTROPIC GLUTAMATE 2/3 RECEPTOR ACTIVATION ON DEFICITS OF NEURAL NETWORK FUNCTION INDUCED BY OPTOGENETIC INHIBITION OF PARVALBUMIN-POSITIVE INTERNEURONS IN THE MOUSE PREFRONTAL CORTEX

Neuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia

Effects of the Glycine Transporter-1 Inhibitor Iclepertin (BI 425809) on Sensory Processing, Neural Network Function, and Cognition in Animal Models Related to Schizophrenia

SA11. Analysis of Auditory Event-Related Potentials and Oscillation in a Mouse Model Related to Schizophrenia by a Novel Technology for Wireless Recording

Reply to the Letter to the Editor regarding; Not mismatch negativity modulation of sensory N1 is measured

Inhibition of cGMP-metabolizing PDEs as target for cognitive enhancement

P376. Preclinical Pharmacological Characterization of the Selective NR2b Negative Allosteric Modulator BI 1569912 With Potential to Treat MDD

Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents

Increasing the Excitatory Drive Rescues Excitatory/Inhibitory Imbalance and Mismatch Negativity Deficit Caused by Parvalbumin Specific GluA1 Deletion

Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders

Electroencephalography as a Clinical Biomarker in a Phase II Substudy With BI 425809 in Patients With Schizophrenia

Effects of the phosphodiesterase 2 inhibitor BI 474121 on central nervous system cyclic guanosine monophosphate concentrations: Translational studies

Effects of mGlu2/3 Receptor Activation on Neural Network and Single Neuron Function in a Prefrontal Cortex Optogenetic Model of E/I Imbalance

Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase‐1 improves cognitive performance

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