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Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases

Science (American Association for the Advancement of Science), 2019-10, Vol.366 (6461), p.109-115

2019

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RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma

Cancer cell, 2017-05, Vol.31 (5), p.685-696.e6

2017

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Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells

Cell reports (Cambridge), 2019-05, Vol.27 (6), p.1858-1874.e6

2019

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RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

Nature cell biology, 2015-06, Vol.17 (6), p.804-815

2015

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Unusual Interplay of Two Types of Ras Activators, RasGRP and SOS, Establishes Sensitive and Robust Ras Activation in Lymphocytes

Molecular and Cellular Biology, 2007-04, Vol.27 (7), p.2732-2745

2007

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Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

PloS one, 2018-05, Vol.13 (5), p.e0193849

2018

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RasGRP Ras guanine nucleotide exchange factors in cancer

Frontiers in biology, 2013-10, Vol.8 (5), p.508-532

2013

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Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells

Frontiers in immunology, 2013-09, Vol.4, p.239-239

2013

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NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

Scientific reports, 2024-07, Vol.14 (1), p.15351-14, Article 15351

2024

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Tonic Signals: Why Do Lymphocytes Bother?

Trends in immunology, 2017-11, Vol.38 (11), p.844-857

2017

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Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells

Cell reports (Cambridge), 2017-05, Vol.19 (8), p.1558-1571

2017

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mTOR and other effector kinase signals that impact T cell function and activity

Immunological reviews, 2019-09, Vol.291 (1), p.134-153

2019

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A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

eLife, 2017-09, Vol.6

2017

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Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer

Cancers, 2019-09, Vol.11 (10), p.1423

2019

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Protocol for Comprehensive Synthetic Lethality Screens

STAR protocols, 2020-06, Vol.1 (1), p.100016, Article 100016

2020

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High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions

Cell reports (Cambridge), 2019-04, Vol.27 (2), p.631-647.e5

2019

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Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

Nature, 2009-09, Vol.461 (7262), p.411-414

2009

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The Membrane Environment Can Promote or Suppress Bistability in Cell Signaling Networks

The journal of physical chemistry. B, 2012-03, Vol.116 (11), p.3630-3640

2012

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A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells

Molecular and Cellular Biology, 2005-06, Vol.25 (11), p.4426-4441

2005

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Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

eLife, 2013-07, Vol.2, p.e00813-e00813

2013

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T cells: a dedicated effector kinase pathways for every trait?

Biochemical journal, 2021-03, Vol.478 (6), p.1303-1307

2021

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Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

Proceedings of the National Academy of Sciences - PNAS, 2009-01, Vol.106 (2), p.528-533

2009

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Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression

PloS one, 2011-09, Vol.6 (9), p.e25540

2011

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Activation of Extracellular Signal-Regulated Kinase but Not of p38 Mitogen-Activated Protein Kinase Pathways in Lymphocytes Requires Allosteric Activation of SOS

Molecular and Cellular Biology, 2013-06, Vol.33 (12), p.2470-2484

2013

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Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

Unusual Interplay of Two Types of Ras Activators, RasGRP and SOS, Establishes Sensitive and Robust Ras Activation in Lymphocytes

Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

RasGRP Ras guanine nucleotide exchange factors in cancer

Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells

NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

Tonic Signals: Why Do Lymphocytes Bother?

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells

mTOR and other effector kinase signals that impact T cell function and activity

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer

Protocol for Comprehensive Synthetic Lethality Screens

High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

The Membrane Environment Can Promote or Suppress Bistability in Cell Signaling Networks

A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

T cells: a dedicated effector kinase pathways for every trait?

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression

Activation of Extracellular Signal-Regulated Kinase but Not of p38 Mitogen-Activated Protein Kinase Pathways in Lymphocytes Requires Allosteric Activation of SOS

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