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Synthesis of halogenated trimetoquinol derivatives and evaluation of their .beta.-agonist and thromboxane A2 (TXA2) antagonist activities

Journal of medicinal chemistry, 1992-02, Vol.35 (3), p.466-479

1992

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Interactions of nonprostanoid trimetoquinol analogs with thromboxane A2/prostaglandin H2 receptors in human platelets, rat vascular endothelial cells and rat vascular smooth muscle cells

The Journal of pharmacology and experimental therapeutics, 1993-12, Vol.267 (3), p.1017

1993

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Differential eudismic ratios in the antagonism of human platelet function by phenoxy- and thiophenoxyacetic acids

Farmaco (Società chimica italiana : 1989), 1996-02, Vol.51 (2), p.107

1996

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Structure-activity studies of new imidazolines on adrenoceptors of rat aorta and human platelets

Naunyn-Schmiedeberg's archives of pharmacology, 1991-10, Vol.344 (4), p.454-463

1991

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Dissociation of hypolipidemic and antiplatelet actions from adverse myotonic effects of clofibric acid related enantiomers

Journal of medicinal chemistry, 1987-08, Vol.30 (8), p.1265-1267

1987

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Characterization of the inhibition of U46619-mediated human platelet activation by the trimetoquinol isomers: evidence for endoperoxide/thromboxane A2 receptor blockade

Biochemical pharmacology, 1988-08, Vol.37 (15), p.3023-3033

1988

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Inhibition of human platelet aggregation and secretion by ant venom and a compound isolated from venom

Inflammation, 1989-04, Vol.13 (2), p.175-184

1989

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Synthesis and thromboxane A2 antagonist activity of N-benzyltrimetoquinol analogs

Journal of medicinal chemistry, 1988-08, Vol.31 (8), p.1506-1512

1988

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Resolution and adrenergic activities of the optical isomers of 4-[1-(1-Naphthyl)ethyl]-1H-imidazole

Chirality (New York, N.Y.), 1992, Vol.4 (7), p.432-438

1992

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Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H 2 synthases by ibuprofen, naproxen, and indomethacin

Biochemical pharmacology, 2001-12, Vol.62 (12), p.1587-1595

2001

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Potent antiplatelet effects of cyclic clofibric acid (CPIB) analogs on human platelets

Thrombosis research, 1989-05, Vol.54 (4), p.289-299

1989

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Halogen-substituted trimetoquinol analogs as thromboxane A2 receptor antagonists in platelets and aorta

Biochemical pharmacology, 1993-12, Vol.46 (11), p.2051-2059

1993

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Synthetic aci-reductones: 3,4-dihydroxy-2H-1-benzopyran-2-ones and their cis- and trans-4a,5,6,7,8,8a-hexahydro diastereomers. Antiaggregatory, antilipidemic, and redox properties compared to those of the 4-substituted 2-hydroxytetronic acids

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1437-1445

1988

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β-adrenergic receptor and platelet inhibitory activities of a new series of trimetoquinol and related benzazepine analogs

General pharmacology, 1997-02, Vol.28 (2), p.323-330

1997

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Pharmacologic antagonism of thromboxane A2 receptors by trimetoquinol analogs in vitro and in vivo

Chirality (New York, N.Y.), 1991, Vol.3 (2), p.112-117

1991

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Synthesis and alpha 2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets

Journal of medicinal chemistry, 1990-04, Vol.33 (4), p.1138-1144

1990

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Pharmacological evaluation of the β-adrenoceptor agonist and thromboxane receptor blocking properties of 1-benzyl substituted trimetoquinol analogues

European journal of pharmacology, 1990-08, Vol.184 (1), p.21-31

1990

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Pharmacological properties of novel bicyclic isoquinoline analogs in isolated guinea pig atria, trachea and in human platelets: Relationship to trimetoquinol

General pharmacology, 1991, Vol.22 (6), p.1155-1163

1991

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Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin

Biochemical pharmacology, 2001-12, Vol.62 (12), p.1587-1595

2001

Volltextzugriff (PDF)

Synthesis and in vitro platelet aggregation and TP receptor binding studies on bicyclic 5,8-ethanooctahydroisoquinolines and 5,8-ethanotetrahydroisoquinolines

Bioorganic & medicinal chemistry, 2002-08, Vol.10 (8), p.2779-2793

2002

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A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on α1- and α2-adrenergic receptors

Journal of medicinal chemistry, 1994-07, Vol.37 (15), p.2328-2333

1994

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A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors

Journal of medicinal chemistry, 1994-07, Vol.37 (15), p.2328-2333

1994

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Synthesis and α2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets

Journal of medicinal chemistry, 1990, Vol.33 (4), p.1138-1144

1990

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Synthesis of halogenated trimethoquinol derivatives and evaluation of their β-agonist and thromboxane A2 (TXA2) antagonist activities

Journal of medicinal chemistry, 1992, Vol.35 (3), p.466-479

1992

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Pharlacikigucak evaluation of the β-adrenoceptor agonist and thromboxane receptor blocking properties of 1-benzyl substituted trimetoquinol analogues

European journal of pharmacology, 1990, Vol.184 (1), p.21-31

1990

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Synthesis of halogenated trimetoquinol derivatives and evaluation of their .beta.-agonist and thromboxane A2 (TXA2) antagonist activities

Interactions of nonprostanoid trimetoquinol analogs with thromboxane A2/prostaglandin H2 receptors in human platelets, rat vascular endothelial cells and rat vascular smooth muscle cells

Differential eudismic ratios in the antagonism of human platelet function by phenoxy- and thiophenoxyacetic acids

Structure-activity studies of new imidazolines on adrenoceptors of rat aorta and human platelets

Dissociation of hypolipidemic and antiplatelet actions from adverse myotonic effects of clofibric acid related enantiomers

Characterization of the inhibition of U46619-mediated human platelet activation by the trimetoquinol isomers: evidence for endoperoxide/thromboxane A2 receptor blockade

Inhibition of human platelet aggregation and secretion by ant venom and a compound isolated from venom

Synthesis and thromboxane A2 antagonist activity of N-benzyltrimetoquinol analogs

Resolution and adrenergic activities of the optical isomers of 4-[1-(1-Naphthyl)ethyl]-1H-imidazole

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H 2 synthases by ibuprofen, naproxen, and indomethacin

Potent antiplatelet effects of cyclic clofibric acid (CPIB) analogs on human platelets

Halogen-substituted trimetoquinol analogs as thromboxane A2 receptor antagonists in platelets and aorta

Synthetic aci-reductones: 3,4-dihydroxy-2H-1-benzopyran-2-ones and their cis- and trans-4a,5,6,7,8,8a-hexahydro diastereomers. Antiaggregatory, antilipidemic, and redox properties compared to those of the 4-substituted 2-hydroxytetronic acids

β-adrenergic receptor and platelet inhibitory activities of a new series of trimetoquinol and related benzazepine analogs

Pharmacologic antagonism of thromboxane A2 receptors by trimetoquinol analogs in vitro and in vivo

Synthesis and alpha 2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets

Pharmacological evaluation of the β-adrenoceptor agonist and thromboxane receptor blocking properties of 1-benzyl substituted trimetoquinol analogues

Pharmacological properties of novel bicyclic isoquinoline analogs in isolated guinea pig atria, trachea and in human platelets: Relationship to trimetoquinol

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin

Synthesis and in vitro platelet aggregation and TP receptor binding studies on bicyclic 5,8-ethanooctahydroisoquinolines and 5,8-ethanotetrahydroisoquinolines

A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on α1- and α2-adrenergic receptors

A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors

Synthesis and α2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets

Synthesis of halogenated trimethoquinol derivatives and evaluation of their β-agonist and thromboxane A2 (TXA2) antagonist activities

Pharlacikigucak evaluation of the β-adrenoceptor agonist and thromboxane receptor blocking properties of 1-benzyl substituted trimetoquinol analogues

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