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Identification of Hepatitis C Virus NS5A Inhibitors

Journal of Virology, 2010-01, Vol.84 (1), p.482-491

2010

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Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

Antimicrobial Agents and Chemotherapy, 2011-08, Vol.55 (8), p.3795-3802

2011

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Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

ACS medicinal chemistry letters, 2011-03, Vol.2 (3), p.224-229

2011

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Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1643-1672

2014

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Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.2013-2032

2014

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Characterizations of HCV NS5A replication complex inhibitors

Virology (New York, N.Y.), 2013-09, Vol.444 (1), p.343-354

2013

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Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097

Journal of organic chemistry, 2017-10, Vol.82 (19), p.10376-10387

2017

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Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1995-2012

2014

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HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6063-6066

2012

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3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: Opener of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels, Identification, Solubility, and SAR

Journal of medicinal chemistry, 2007-02, Vol.50 (3), p.528-542

2007

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3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR

Journal of medicinal chemistry, 2007-02, Vol.50 (3), p.528-542

2007

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HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1976-1994

2014

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The Synthesis and evaluation of a novel class of ( E)-3-(1-cyclohexyl-1 H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2869-2872

2011

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Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements

Bioorganic & medicinal chemistry, 2004-01, Vol.12 (2), p.507-521

2004

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4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.2942-2952

2002

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4,5-Diphenyltriazol-3-ones: Openers of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels

Journal of medicinal chemistry, 2002-07, Vol.45 (14), p.2942-2952

2002

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Total synthesis of (+)-ikarugamycin. 1. Stereocontrolled construction of the decahydro-as-indacene subunit

Journal of the American Chemical Society, 1990-12, Vol.112 (25), p.9284-9292

1990

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HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1976-1994

2014

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Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3884-3903

1993

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Preparation of 5-Substituted 2-(2-Alkyl/aryl-1 H -imidazol-4-yl)oxazoles and 5-Substituted 2-(2-Alkyl/arylthiazol-4-yl)oxazoles by Utilizing 5-Substituted 2-(2-Bromo-1,1-diethoxyethyl)oxazole as a Synthon

Synthesis (Stuttgart), 2009-05, Vol.2009 (9), p.1445-1458

2009

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Diastereoselective cyclopropanations of chiral bicyclic lactams leading to enantiomerically pure cyclopropanes. Application to the total synthesis of CIS-(1S, 3R)-deltamethrinic acid and R-(-)- dictyopterene C

Tetrahedron, 1990, Vol.46 (13), p.4951-4994

1990

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A rapid and efficient synthesis of chiral 2-hydro-2-oxazolines

Journal of organic chemistry, 1991-03, Vol.56 (5), p.1961-1963

1991

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Effects of channel modulators on cloned large-conductance calcium-activated potassium channels

Molecular pharmacology, 1996-07, Vol.50 (1), p.206

1996

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Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety

Journal of medicinal chemistry, 1992-09, Vol.35 (19), p.3498-3512

1992

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Diastereoselective π-facially controlled nucleophilic additions of chiral vinylorganometallics to chiral β,γ-unsaturated ketones. 2. A practical method for stereocontrolled elaboration of the decahydro- [formula omitted]-indacene subunit of ikarugamycin

Tetrahedron letters, 1987, Vol.28 (1), p.31-34

1987

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Identification of Hepatitis C Virus NS5A Inhibitors

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir

Characterizations of HCV NS5A replication complex inhibitors

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: Opener of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels, Identification, Solubility, and SAR

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR

HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity

The Synthesis and evaluation of a novel class of ( E)-3-(1-cyclohexyl-1 H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors

Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements

4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels

4,5-Diphenyltriazol-3-ones: Openers of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels

Total synthesis of (+)-ikarugamycin. 1. Stereocontrolled construction of the decahydro-as-indacene subunit

HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity

Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid

Preparation of 5-Substituted 2-(2-Alkyl/aryl-1 H -imidazol-4-yl)oxazoles and 5-Substituted 2-(2-Alkyl/arylthiazol-4-yl)oxazoles by Utilizing 5-Substituted 2-(2-Bromo-1,1-diethoxyethyl)oxazole as a Synthon

Diastereoselective cyclopropanations of chiral bicyclic lactams leading to enantiomerically pure cyclopropanes. Application to the total synthesis of CIS-(1S, 3R)-deltamethrinic acid and R-(-)- dictyopterene C

A rapid and efficient synthesis of chiral 2-hydro-2-oxazolines

Effects of channel modulators on cloned large-conductance calcium-activated potassium channels

Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety

Diastereoselective π-facially controlled nucleophilic additions of chiral vinylorganometallics to chiral β,γ-unsaturated ketones. 2. A practical method for stereocontrolled elaboration of the decahydro- [formula omitted]-indacene subunit of ikarugamycin

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