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Rational design of a new antibiotic class for drug-resistant infections

Nature (London), 2021-09, Vol.597 (7878), p.698-702

2021

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Lanthanocene Catalysts in Selective Organic Synthesis

Chemical reviews, 2002-06, Vol.102 (6), p.2161-2186

2002

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Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4948-4964

2016

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N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (24), p.115826-115826, Article 115826

2020

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Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β‑Lactamases

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12511-12525

2020

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Stereochemistry of Nucleophilic Substitution Reactions Depending upon Substituent: Evidence for Electrostatic Stabilization of Pseudoaxial Conformers of Oxocarbenium Ions by Heteroatom Substituents

Journal of the American Chemical Society, 2003-12, Vol.125 (50), p.15521-15528

2003

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Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

Angewandte Chemie (International ed.), 2007-06, Vol.46 (23), p.4367-4369

2007

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Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

Journal of medicinal chemistry, 2010-06, Vol.53 (12), p.4701-4719

2010

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Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors

Journal of medicinal chemistry, 2015-11, Vol.58 (21), p.8503-8512

2015

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Stereochemical Reversal of Nucleophilic Substitution Reactions Depending upon Substituent: Reactions of Heteroatom-Substituted Six-Membered-Ring Oxocarbenium Ions through Pseudoaxial Conformers

Journal of the American Chemical Society, 2000-01, Vol.122 (1), p.168-169

2000

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Structure-based discovery of LpxC inhibitors

Bioorganic & medicinal chemistry letters, 2017-04, Vol.27 (8), p.1670-1680

2017

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Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

ACS medicinal chemistry letters, 2016-04, Vol.7 (4), p.374-378

2016

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Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors

ACS medicinal chemistry letters, 2015-10, Vol.6 (10), p.1080-1085

2015

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Modeling re-absorption of fluorescence from the leaf to the canopy level

Remote sensing of environment, 2018-01, Vol.204, p.138-146

2018

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Biarylsulfonamide CCR9 inhibitors for inflammatory bowel disease

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3661-3664

2015

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In-silico guided discovery of novel CCR9 antagonists

Journal of computer-aided molecular design, 2018-04, Vol.32 (4), p.573-582

2018

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Discovery of indole inhibitors of chemokine receptor 9 (CCR9)

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (14), p.3322-3325

2016

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Investigations concerning the organolanthanide and group 3 metallocene-catalyzed cyclization–functionalization of nitrogen-containing dienes

Tetrahedron, 2005-03, Vol.61 (10), p.2631-2643

2005

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Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3743-3748

2011

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Hydrosilylation of alkynylsilanes utilizing organolanthanide and Group 3 metallocene complexes

Journal of organometallic chemistry, 2002-03, Vol.647 (1-2), p.225-235

2002

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Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

Angewandte Chemie, 2007-06, Vol.119 (23), p.4445-4447

2007

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Imatinib-Resistant BCR-ABL Mutant Cellular Screening Paradigm To Characterize Promising Small-Molecule Inhibitors: T315I-BCR-ABL Targeted Drug Discovery

Blood, 2006-11, Vol.108 (11), p.2181-2181

2006

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Orally Active Inhibitors of the Imatinib Resistant Bcr-Abl Mutant T315I

Blood, 2006-11, Vol.108 (11), p.2180-2180

2006

Volltextzugriff (PDF)

Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

Angewandte Chemie, 2007-06, Vol.119 (23), p.4445-4447

2007

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Functionalization of unsaturated molecules utilizing group 3 and organolanthanide metallocenes

Romero, Jan Antoinette C

2004

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Rational design of a new antibiotic class for drug-resistant infections

Lanthanocene Catalysts in Selective Organic Synthesis

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase

N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β‑Lactamases

Stereochemistry of Nucleophilic Substitution Reactions Depending upon Substituent: Evidence for Electrostatic Stabilization of Pseudoaxial Conformers of Oxocarbenium Ions by Heteroatom Substituents

Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors

Stereochemical Reversal of Nucleophilic Substitution Reactions Depending upon Substituent: Reactions of Heteroatom-Substituted Six-Membered-Ring Oxocarbenium Ions through Pseudoaxial Conformers

Structure-based discovery of LpxC inhibitors

Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors

Modeling re-absorption of fluorescence from the leaf to the canopy level

Biarylsulfonamide CCR9 inhibitors for inflammatory bowel disease

In-silico guided discovery of novel CCR9 antagonists

Discovery of indole inhibitors of chemokine receptor 9 (CCR9)

Investigations concerning the organolanthanide and group 3 metallocene-catalyzed cyclization–functionalization of nitrogen-containing dienes

Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant

Hydrosilylation of alkynylsilanes utilizing organolanthanide and Group 3 metallocene complexes

Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

Imatinib-Resistant BCR-ABL Mutant Cellular Screening Paradigm To Characterize Promising Small-Molecule Inhibitors: T315I-BCR-ABL Targeted Drug Discovery

Orally Active Inhibitors of the Imatinib Resistant Bcr-Abl Mutant T315I

Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

Functionalization of unsaturated molecules utilizing group 3 and organolanthanide metallocenes

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