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Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3432-3435

2006

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Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

Journal of the American Chemical Society, 2005-07, Vol.127 (29), p.10130-10131

2005

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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

Analytical biochemistry, 2004-09, Vol.332 (2), p.261-273

2004

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Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6139-6142

2006

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Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2430-2440

2004

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Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Nucleic acids research, 2006-10, Vol.34 (18), p.5157-5165

2006

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Recent Progress of Synthetic Studies to Peptide and Peptidomimetic Cyclization

Current organic chemistry, 2008-11, Vol.12 (17), p.1502-1542

2008

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Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP

Journal of the American Chemical Society, 2007-12, Vol.129 (49), p.15279-15294

2007

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Cyclization strategies in peptide derived drug design

Current topics in medicinal chemistry, 2002-03, Vol.2 (3), p.325-341

2002

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Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4313-4324

2001

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Structure-Based Design of Potent, Conformationally Constrained Smac Mimetics

Journal of the American Chemical Society, 2004-12, Vol.126 (51), p.16686-16687

2004

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Structure-Based Design, Synthesis, and Evaluation of Conformationally Constrained Mimetics of the Second Mitochondria-Derived Activator of Caspase That Target the X-Linked Inhibitor of Apoptosis Protein/Caspase-9 Interaction Site

Journal of medicinal chemistry, 2004-08, Vol.47 (17), p.4147-4150

2004

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Current Synthetic Approaches to Peptide and Peptidomimetic Cyclization

Current organic chemistry, 2002-04, Vol.6 (5), p.411-440

2002

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Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

Biochemical pharmacology, 2003-07, Vol.66 (1), p.93-103

2003

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Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein

Biochemistry (Easton), 2008-09, Vol.47 (37), p.9811-9824

2008

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Discovery of a Novel Nonphosphorylated Pentapeptide Motif Displaying High Affinity for Grb2-SH2 Domain by the Utilization of 3‘-Substituted Tyrosine Derivatives

Journal of medicinal chemistry, 2006-03, Vol.49 (5), p.1585-1596

2006

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Design and Synthesis of Novel and Potent Inhibitors of the Type II Transmembrane Serine Protease, Matriptase, Based upon the Sunflower Trypsin Inhibitor-1

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.5976-5983

2007

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Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

Analytical biochemistry, 2008-03, Vol.374 (1), p.87-98

2008

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Design and Synthesis of Redox Stable Analogues of Sunflower Trypsin Inhibitors (SFTI-1) on Solid Support, Potent Inhibitors of Matriptase

Organic letters, 2007-01, Vol.9 (1), p.9-12

2007

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Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins

Journal of medicinal chemistry, 2007-07, Vol.50 (14), p.3163-3166

2007

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Identification of Novel Non-phosphorylated Ligands, Which Bind Selectively to the SH2 Domain of Grb7

The Journal of biological chemistry, 2002-04, Vol.277 (14), p.11918-11926

2002

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Pyrogallol-Based Molecules as Potent Inhibitors of the Antiapoptotic Bcl-2 Proteins

Journal of medicinal chemistry, 2007-04, Vol.50 (8), p.1723-1726

2007

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New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.3034-3038

2006

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The Arf GTPase-Activating Protein ASAP1 Regulates the Actin Cytoskeleton

Proceedings of the National Academy of Sciences - PNAS, 2000-04, Vol.97 (8), p.4011-4016

2000

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Structural Basis for Inhibition of the Protein Tyrosine Phosphatase 1B by Phosphotyrosine Peptide Mimetics

Biochemistry (Easton), 1998-12, Vol.37 (51), p.17773-17783

1998

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Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins

Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Recent Progress of Synthetic Studies to Peptide and Peptidomimetic Cyclization

Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP

Cyclization strategies in peptide derived drug design

Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening

Structure-Based Design of Potent, Conformationally Constrained Smac Mimetics

Structure-Based Design, Synthesis, and Evaluation of Conformationally Constrained Mimetics of the Second Mitochondria-Derived Activator of Caspase That Target the X-Linked Inhibitor of Apoptosis Protein/Caspase-9 Interaction Site

Current Synthetic Approaches to Peptide and Peptidomimetic Cyclization

Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein

Discovery of a Novel Nonphosphorylated Pentapeptide Motif Displaying High Affinity for Grb2-SH2 Domain by the Utilization of 3‘-Substituted Tyrosine Derivatives

Design and Synthesis of Novel and Potent Inhibitors of the Type II Transmembrane Serine Protease, Matriptase, Based upon the Sunflower Trypsin Inhibitor-1

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains

Design and Synthesis of Redox Stable Analogues of Sunflower Trypsin Inhibitors (SFTI-1) on Solid Support, Potent Inhibitors of Matriptase

Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins

Identification of Novel Non-phosphorylated Ligands, Which Bind Selectively to the SH2 Domain of Grb7

Pyrogallol-Based Molecules as Potent Inhibitors of the Antiapoptotic Bcl-2 Proteins

New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity

The Arf GTPase-Activating Protein ASAP1 Regulates the Actin Cytoskeleton

Structural Basis for Inhibition of the Protein Tyrosine Phosphatase 1B by Phosphotyrosine Peptide Mimetics

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