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Understanding and Modulating Antibody Fine Specificity: Lessons from Combinatorial Biology

Antibodies (Basel), 2022-07, Vol.11 (3), p.48

Rojas, Gertrudis

2022

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Baculovirus-free insect cell expression system for high yield antibody and antigen production

Scientific reports, 2020-12, Vol.10 (1), p.21393-21393, Article 21393

2020

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Domain-level epitope mapping of polyclonal antibodies against HER-1 and HER-2 receptors using phage display technology

Scientific reports, 2022-07, Vol.12 (1), p.12268-12268, Article 12268

2022

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Studying SARS-CoV-2 interactions using phage-displayed receptor binding domain as a model protein

Scientific reports, 2024-01, Vol.14 (1), p.712-712, Article 712

2024

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Affinity-matured variants derived from nimotuzumab keep the original fine specificity and exhibit superior biological activity

Scientific reports, 2020-01, Vol.10 (1), p.1194, Article 1194

2020

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In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum

Analytical and bioanalytical chemistry, 2021-12, Vol.413 (30), p.7559-7585

2021

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Directed evolution of super-secreted variants from phage-displayed human Interleukin-2

Scientific reports, 2019-01, Vol.9 (1), p.800-800, Article 800

2019

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Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping

Immunobiology (1979), 2013-01, Vol.218 (1), p.105-113

2013

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Development of a scalable single process for producing SARS-CoV-2 RBD monomer and dimer vaccine antigens

Frontiers in bioengineering and biotechnology, 2023-11, Vol.11, p.1287551-1287551

2023

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Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles

Communications biology, 2023-08, Vol.6 (1), p.828-828, Article 828

2023

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Phagekines: Screening Binding Properties and Biological Activity of Functional Cytokines Displayed on Phages

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1701, p.535

2018

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A simple vector system to improve performance and utilisation of recombinant antibodies

BMC biotechnology, 2006-12, Vol.6 (1), p.46-46, Article 46

2006

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Development and validation of a quantitative ELISA for the measurement of PSA concentration

Clinica chimica acta, 2002-03, Vol.317 (1), p.55-63

2002

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TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity

The Journal of immunology (1950), 2002-07, Vol.169 (2), p.1110-1118

2002

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Structure and Molecular Interactions of a Unique Antitumor Antibody Specific for N-Glycolyl GM3

The Journal of biological chemistry, 2004-02, Vol.279 (7), p.5597-5603

2004

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Molecular dissection of the interactions of an antitumor interleukin-2-derived mutein on a phage display-based platform

Journal of molecular recognition, 2015-04, Vol.28 (4), p.261-268

2015

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Light-chain shuffling results in successful phage display selection of functional prokaryotic-expressed antibody fragments to N-glycolyl GM3 ganglioside

Journal of immunological methods, 2004-10, Vol.293 (1), p.71-83

2004

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High throughput functional epitope mapping: Revisiting phage display platform to scan target antigen surface

mAbs, 2014-11, Vol.6 (6), p.1368-1376

2014

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A combinatorial mutagenesis approach for functional epitope mapping on phage-displayed target antigen: Application to antibodies against epidermal growth factor

mAbs, 2014-05, Vol.6 (3), p.637-648

2014

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SARS-CoV‑2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies

ACS chemical biology, 2021-07, Vol.16 (7), p.1223-1233

2021

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Combining computational and experimental biology to develop therapeutically valuable IL2 muteins

Seminars in oncology, 2018-01, Vol.45 (1-2), p.95-104

2018

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Fine epitope mapping based on phage display and extensive mutagenesis of the target antigen

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1131, p.447

Rojas, Gertrudis

2014

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Abstract B011: Human IL-2 mutant exhibits a higher antitumor efficacy and lower toxicity than wildtype IL-2 in different preclinical contexts

Cancer immunology research, 2016-11, Vol.4 (11_Supplement), p.B011-B011

2016

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Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects

mAbs, 2014-01, Vol.6 (1), p.273-285

2014

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Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture

Scientific reports, 2018-07, Vol.8 (1), p.10836-11, Article 10836

2018

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Understanding and Modulating Antibody Fine Specificity: Lessons from Combinatorial Biology

Baculovirus-free insect cell expression system for high yield antibody and antigen production

Domain-level epitope mapping of polyclonal antibodies against HER-1 and HER-2 receptors using phage display technology

Studying SARS-CoV-2 interactions using phage-displayed receptor binding domain as a model protein

Affinity-matured variants derived from nimotuzumab keep the original fine specificity and exhibit superior biological activity

In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum

Directed evolution of super-secreted variants from phage-displayed human Interleukin-2

Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping

Development of a scalable single process for producing SARS-CoV-2 RBD monomer and dimer vaccine antigens

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles

Phagekines: Screening Binding Properties and Biological Activity of Functional Cytokines Displayed on Phages

A simple vector system to improve performance and utilisation of recombinant antibodies

Development and validation of a quantitative ELISA for the measurement of PSA concentration

TCR-Like Human Antibodies Expressed on Human CTLs Mediate Antibody Affinity-Dependent Cytolytic Activity

Structure and Molecular Interactions of a Unique Antitumor Antibody Specific for N-Glycolyl GM3

Molecular dissection of the interactions of an antitumor interleukin-2-derived mutein on a phage display-based platform

Light-chain shuffling results in successful phage display selection of functional prokaryotic-expressed antibody fragments to N-glycolyl GM3 ganglioside

High throughput functional epitope mapping: Revisiting phage display platform to scan target antigen surface

A combinatorial mutagenesis approach for functional epitope mapping on phage-displayed target antigen: Application to antibodies against epidermal growth factor

SARS-CoV‑2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies

Combining computational and experimental biology to develop therapeutically valuable IL2 muteins

Fine epitope mapping based on phage display and extensive mutagenesis of the target antigen

Abstract B011: Human IL-2 mutant exhibits a higher antitumor efficacy and lower toxicity than wildtype IL-2 in different preclinical contexts

Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects

Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture

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