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The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future

Frontiers in pharmacology, 2024-03, Vol.15, p.1369079-1369079

2024

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Pharmacodynamics and Pharmacokinetics of AM103, a Novel Inhibitor of 5-Lipoxygenase-Activating Protein ( )

Clinical pharmacology and therapeutics, 2010-04, Vol.87 (4), p.437-444

2010

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An evaluation of human ADME and mass balance studies using regular or low doses of radiocarbon

Journal of labelled compounds & radiopharmaceuticals, 2016-12, Vol.59 (14), p.619-626

2016

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Defects in muscarinic receptor-coupled signal transduction in isolated parotid gland cells after in vivo irradiation: evidence for a non-DNA target of radiation

British journal of cancer, 2005-02, Vol.92 (3), p.539-546

2005

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Muscarinic control of airway function

Life sciences (1973), 1997, Vol.60 (13), p.1061-1068

1997

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Early Radiation Effects on Muscarinic Receptor-Induced Secretory Responsiveness of the Parotid Gland in the Freely Moving Rat

Radiation research, 2000-03, Vol.153 (3), p.339-346

2000

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Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle

British journal of pharmacology, 1990-02, Vol.99 (2), p.293-296

1990

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No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea

British journal of pharmacology, 1995-06, Vol.115 (4), p.665-671

1995

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Muscarinic inhibitory autoreceptors in different generations of human airways

American journal of respiratory and critical care medicine, 1996-07, Vol.154 (1), p.43-49

1996

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Metabolism and excretion of GCC-4401C, a factor Xa inhibitor, in humans

International journal of pharmacokinetics, 2017-05, Vol.2 (2), p.93-104

2017

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Muscarinic M2 receptors in bovine tracheal smooth muscle: discrepancies between binding and function

European journal of pharmacology, 1988-08, Vol.153 (1), p.73-82

1988

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Characterization of the muscarinic receptor subtype(s) mediating contraction of the guinea‐pig lung strip and inhibition of acetylcholine release in the guinea‐pig trachea with the selective muscarinic receptor antagonist tripitramine

British journal of pharmacology, 1997-09, Vol.122 (1), p.133-141

1997

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Contribution of a cholinergic reflex mechanism to allergen‐induced bronchial hyperreactivity in permanently instrumented, unrestrained guinea‐pigs

British journal of pharmacology, 1995-01, Vol.114 (2), p.414-418

1995

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Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists

European journal of pharmacology, 1988-11, Vol.156 (2), p.271-274

1988

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Characterization of presynaptic vascular muscarinic receptors inhibiting endogenous noradrenaline overflow in the portal vein of the freely moving rat

British journal of pharmacology, 1990-02, Vol.99 (2), p.223-226

1990

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Heterogeneity of prejunctional neuropeptide Y receptors inhibiting noradrenaline overflow in the portal vein of freely moving rats

European journal of pharmacology, 1994-08, Vol.261 (3), p.311-316

1994

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Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle

European journal of pharmacology, 2001-11, Vol.431 (3), p.353

2001

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Differences in the prejunctional effects of methacholine and pilocarpine on the release of endogenous acetylcholine from guinea-pig trachea

Naunyn-Schmiedeberg's archives of pharmacology, 1996-11, Vol.354 (5), p.606-611

1996

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Dysfunctional muscarinic M2 autoreceptors in vagally induced bronchoconstriction of conscious guinea pigs after the early allergic reaction

European journal of pharmacology, 1996-12, Vol.318 (1), p.131-139

1996

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Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea‐pigs

British journal of pharmacology, 1995-02, Vol.114 (4), p.881-887

1995

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Metabolism and Excretion of Intravenous, Radio-Labeled Amisulpride in Healthy, Adult Volunteers

Clinical pharmacology: advances and applications, 2019-12, Vol.11, p.161-169

2019

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The M2 selective antagonist AF-DX 116 shows high affinity for muscarine receptors in bovine tracheal membranes

Naunyn-Schmiedeberg's archives of pharmacology, 1987-05, Vol.335 (5), p.593-595

1987

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Muscarinic M2 receptors do not participate in the functional antagonism between methacholine and isoprenaline in guinea pig tracheal smooth muscle

European journal of pharmacology, 1993-11, Vol.249 (2), p.235-238

1993

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Beta-agonist-induced constitutive beta(2)-adrenergic receptor activity in bovine tracheal smooth muscle

British journal of pharmacology, 2000-11, Vol.131 (5), p.915-920

2000

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The interaction of selective and non-selective antagonists with pre- and postjunctional muscarinic receptor subtypes in the guinea pig trachea

European journal of pharmacology, 1993-03, Vol.233 (2), p.279-284

1993

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The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future

Pharmacodynamics and Pharmacokinetics of AM103, a Novel Inhibitor of 5-Lipoxygenase-Activating Protein ( )

An evaluation of human ADME and mass balance studies using regular or low doses of radiocarbon

Defects in muscarinic receptor-coupled signal transduction in isolated parotid gland cells after in vivo irradiation: evidence for a non-DNA target of radiation

Muscarinic control of airway function

Early Radiation Effects on Muscarinic Receptor-Induced Secretory Responsiveness of the Parotid Gland in the Freely Moving Rat

Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle

No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea

Muscarinic inhibitory autoreceptors in different generations of human airways

Metabolism and excretion of GCC-4401C, a factor Xa inhibitor, in humans

Muscarinic M2 receptors in bovine tracheal smooth muscle: discrepancies between binding and function

Characterization of the muscarinic receptor subtype(s) mediating contraction of the guinea‐pig lung strip and inhibition of acetylcholine release in the guinea‐pig trachea with the selective muscarinic receptor antagonist tripitramine

Contribution of a cholinergic reflex mechanism to allergen‐induced bronchial hyperreactivity in permanently instrumented, unrestrained guinea‐pigs

Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists

Characterization of presynaptic vascular muscarinic receptors inhibiting endogenous noradrenaline overflow in the portal vein of the freely moving rat

Heterogeneity of prejunctional neuropeptide Y receptors inhibiting noradrenaline overflow in the portal vein of freely moving rats

Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle

Differences in the prejunctional effects of methacholine and pilocarpine on the release of endogenous acetylcholine from guinea-pig trachea

Dysfunctional muscarinic M2 autoreceptors in vagally induced bronchoconstriction of conscious guinea pigs after the early allergic reaction

Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea‐pigs

Metabolism and Excretion of Intravenous, Radio-Labeled Amisulpride in Healthy, Adult Volunteers

The M2 selective antagonist AF-DX 116 shows high affinity for muscarine receptors in bovine tracheal membranes

Muscarinic M2 receptors do not participate in the functional antagonism between methacholine and isoprenaline in guinea pig tracheal smooth muscle

Beta-agonist-induced constitutive beta(2)-adrenergic receptor activity in bovine tracheal smooth muscle

The interaction of selective and non-selective antagonists with pre- and postjunctional muscarinic receptor subtypes in the guinea pig trachea

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