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In vitro growth competition experiments that suggest consequences of the substandard artemisinin epidemic that may be accelerating drug resistance in P. falciparum malaria

PloS one, 2021-03, Vol.16 (3), p.e0248057-e0248057

2021

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Structures of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) Isoforms and Their Interactions with Chloroquine

Biochemistry (Easton), 2023-03, Vol.62 (5), p.1093-1110

2023

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Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5231-5246

2013

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Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance

Biochemistry (Easton), 2020-07, Vol.59 (27), p.2484-2493

2020

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Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4‑Kinase IIIβ

Biochemistry (Easton), 2020-07, Vol.59 (27), p.2494-2506

2020

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Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

PLoS pathogens, 2022-02, Vol.18 (2), p.e1010278-e1010278

2022

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Quantification of Free Ferriprotoporphyrin IX Heme and Hemozoin for Artemisinin Sensitive versus Delayed Clearance Phenotype Plasmodium falciparum Malarial Parasites

Biochemistry (Easton), 2018-12, Vol.57 (51), p.6927-6934

2018

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Dihydroartemisinin–Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance

Biochemistry (Easton), 2018-12, Vol.57 (51), p.6935-6945

2018

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Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanisms

PloS one, 2013-11, Vol.8 (11), p.e80790

2013

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PfCRT-Mediated Drug Transport in Malarial Parasites

Biochemistry (Easton), 2011-01, Vol.50 (2), p.163-171

Roepe, Paul D

2011

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Origin and Spread of Evolving Artemisinin-Resistant Plasmodium falciparum Malarial Parasites in Southeast Asia

The American journal of tropical medicine and hygiene, 2019-12, Vol.101 (6), p.1204-1211

2019

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Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

Nature (London), 2019-12, Vol.576 (7786), p.315-320

2019

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An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion

PLoS pathogens, 2019-06, Vol.15 (6), p.e1007775-e1007775

2019

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To kill or not to kill, that is the question: cytocidal antimalarial drug resistance

Trends in parasitology, 2014-03, Vol.30 (3), p.130-135

Roepe, Paul D

2014

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PIK-ing New Malaria Chemotherapy

Trends in parasitology, 2018-11, Vol.34 (11), p.925-927

2018

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Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance

Tropical medicine and infectious disease, 2019-06, Vol.4 (2), p.89

2019

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Artemisinin-Based Drugs Target the Plasmodium falciparum Heme Detoxification Pathway

Antimicrobial agents and chemotherapy, 2021-03, Vol.65 (4)

2021

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Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)

Biochemistry (Easton), 2015-08, Vol.54 (32), p.5083-5094

2015

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High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

Scientific reports, 2015-09, Vol.5 (1), p.13891, Article 13891

2015

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Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

PLoS pathogens, 2016-11, Vol.12 (11), p.e1005976-e1005976

2016

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A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum

PloS one, 2013-11, Vol.8 (11), p.e79059-e79059

2013

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Autophagy is a cell death mechanism in Toxoplasma gondii

Cellular microbiology, 2012-04, Vol.14 (4), p.589-607

2012

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Autophagy in Apicomplexa: a life sustaining death mechanism?

Trends in parasitology, 2012-09, Vol.28 (9), p.358-364

2012

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Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3′-Kinase

Biochemistry (Easton), 2017-08, Vol.56 (33), p.4335-4345

2017

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Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

mBio, 2024-01, Vol.15 (1), p.e0183223-e0183223

2024

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In vitro growth competition experiments that suggest consequences of the substandard artemisinin epidemic that may be accelerating drug resistance in P. falciparum malaria

Structures of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) Isoforms and Their Interactions with Chloroquine

Quinoline Drug–Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities

Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance

Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4‑Kinase IIIβ

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

Quantification of Free Ferriprotoporphyrin IX Heme and Hemozoin for Artemisinin Sensitive versus Delayed Clearance Phenotype Plasmodium falciparum Malarial Parasites

Dihydroartemisinin–Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance

Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanisms

PfCRT-Mediated Drug Transport in Malarial Parasites

Origin and Spread of Evolving Artemisinin-Resistant Plasmodium falciparum Malarial Parasites in Southeast Asia

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion

To kill or not to kill, that is the question: cytocidal antimalarial drug resistance

PIK-ing New Malaria Chemotherapy

Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance

Artemisinin-Based Drugs Target the Plasmodium falciparum Heme Detoxification Pathway

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT)

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum

Autophagy is a cell death mechanism in Toxoplasma gondii

Autophagy in Apicomplexa: a life sustaining death mechanism?

Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3′-Kinase

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

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