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The profibrotic role of endothelin-1: Is the door still open for the treatment of fibrotic diseases?

Life sciences (1973), 2014-11, Vol.118 (2), p.156-164

2014

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Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction

Cardiovascular research, 2016-01, Vol.109 (1), p.67-78

2016

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Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm

Free radical biology & medicine, 2018-04, Vol.118, p.44-58

2018

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Blocking TGF-β1 Protects the Peritoneal Membrane from Dialysate-Induced Damage

Journal of the American Society of Nephrology, 2011-09, Vol.22 (9), p.1682-1695

2011

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Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability

Molecular and Cellular Biology, 2008-12, Vol.28 (23), p.7139-7155

2008

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How evolution made the matrix punch at the multicellularity party

The Journal of biological chemistry, 2019-01, Vol.294 (3), p.770-771

Rodríguez-Pascual, Fernando

2019

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Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress

Free radical biology & medicine, 2012-03, Vol.52 (6), p.1093-1100

2012

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Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation

Journal of cell science, 2007-04, Vol.120 (Pt 7), p.1256-1266

2007

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Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors

Molecular and Cellular Biology, 2006-07, Vol.26 (14), p.5518-5527

2006

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A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor β1

The Journal of biological chemistry, 2019-09, Vol.294 (39), p.14308-14318

2019

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Myocardial fibrosis in response to pressure overload: elucidating the contribution of tissue transglutaminase

Cardiovascular research, 2017-07, Vol.113 (8), p.841-843

2017

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Functional Cooperation Between Smad Proteins and Activator Protein-1 Regulates Transforming Growth Factor-β–Mediated Induction of Endothelin-1 Expression

Circulation research, 2003-06, Vol.92 (12), p.1288-1295

2003

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Role of endothelin in the cardiovascular system

Pharmacological research, 2011-06, Vol.63 (6), p.463-472

2011

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Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome

Arteriosclerosis, thrombosis, and vascular biology, 2015-04, Vol.35 (4), p.960

2015

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LOXL4 Is Induced by Transforming Growth Factor β1 through Smad and JunB/Fra2 and Contributes to Vascular Matrix Remodeling

Molecular and Cellular Biology, 2013-06, Vol.33 (12), p.2388-2401

2013

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Boosting collagen deposition with a lysyl oxidase/bone morphogenetic protein-1 cocktail

Methods in cell biology, 2020, Vol.156, p.259-270

2020

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Altered TGF-β endocytic trafficking contributes to the increased signaling in Marfan syndrome

Biochimica et biophysica acta. Molecular basis of disease, 2018-02, Vol.1864 (2), p.554-562

2018

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Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase

American journal of respiratory cell and molecular biology, 2012-12, Vol.47 (6), p.834-842

2012

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The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis

Cardiovascular research, 2012-02, Vol.93 (2), p.232-241

2012

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Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis

Molecular biology of the cell, 2017-12, Vol.28 (26), p.3741-3755

2017

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Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Arthritis and rheumatism, 2012-05, Vol.64 (5), p.1653-1664

2012

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Workshop on cardiovascular extracellular matrix in health and disease in Baeza, Spain

Fibrogenesis & tissue repair, 2015-02, Vol.8 (1), Article 2

2015

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Collagen cross-linking: insights on the evolution of metazoan extracellular matrix

Scientific reports, 2016-11, Vol.6 (1), p.37374-37374, Article 37374

2016

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Origin and evolution of lysyl oxidases

Scientific reports, 2015-05, Vol.5 (1), p.10568-10568, Article 10568

2015

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Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain

The Journal of biological chemistry, 2019-07, Vol.294 (29), p.11087-11100

2019

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The profibrotic role of endothelin-1: Is the door still open for the treatment of fibrotic diseases?

Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction

Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm

Blocking TGF-β1 Protects the Peritoneal Membrane from Dialysate-Induced Damage

Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability

How evolution made the matrix punch at the multicellularity party

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress

Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation

Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors

A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor β1

Myocardial fibrosis in response to pressure overload: elucidating the contribution of tissue transglutaminase

Functional Cooperation Between Smad Proteins and Activator Protein-1 Regulates Transforming Growth Factor-β–Mediated Induction of Endothelin-1 Expression

Role of endothelin in the cardiovascular system

Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome

LOXL4 Is Induced by Transforming Growth Factor β1 through Smad and JunB/Fra2 and Contributes to Vascular Matrix Remodeling

Boosting collagen deposition with a lysyl oxidase/bone morphogenetic protein-1 cocktail

Altered TGF-β endocytic trafficking contributes to the increased signaling in Marfan syndrome

Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase

The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis

Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Workshop on cardiovascular extracellular matrix in health and disease in Baeza, Spain

Collagen cross-linking: insights on the evolution of metazoan extracellular matrix

Origin and evolution of lysyl oxidases

Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain

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