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Errors in translation act as a “tipping point” leading to the onset of neurodegenerative disease

BioEssays, 2023-07, Vol.45 (7), p.e2300081-n/a

Rochet, Jean‐Christophe

2023

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Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

Annals of neurology, 2011-06, Vol.69 (6), p.940-953

2011

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Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

The Journal of neuroscience, 2021-12, Vol.41 (49), p.10194-10208

2021

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Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

Neurobiology of disease, 2015-07, Vol.79, p.150-163

2015

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Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (1), p.145-150

2008

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Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease

Molecular and cellular neuroscience, 2018-04, Vol.88, p.70-82

2018

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Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases

Biology (Basel, Switzerland), 2023-08, Vol.12 (9), p.1169

2023

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Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

Neurobiology of disease, 2015-09, Vol.81, p.76-92

2015

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Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease

Journal of neurochemistry, 2008-06, Vol.105 (6), p.2435-2453

2008

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Novel therapeutic strategies for the treatment of protein-misfolding diseases

Expert reviews in molecular medicine, 2007-06, Vol.9 (17), p.1-34

Rochet, Jean-Christophe

2007

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Calcein Release Assay to Measure Membrane Permeabilization by Recombinant Alpha-Synuclein

Bio-protocol, 2020-07, Vol.10 (14)

2020

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DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

Neurobiology of disease, 2020-02, Vol.134, p.104629-104629, Article 104629

2020

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Shining a light on autophagy in neurodegenerative diseases

The Journal of biological chemistry, 2022-01, Vol.298 (1), p.101437-101437, Article 101437

2022

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Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

Neurobiology of disease, 2017-10, Vol.106, p.191-204

2017

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New insights into lysosomal dysfunction in parkinson's disease: An emerging role for ATP13A2

Movement Disorders, 2012-08, Vol.27 (9), p.1092-1092

Rochet, Jean-Christophe

2012

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Acceleration of Oligomerization, Not Fibrillization, Is a Shared Property of Both α -Synuclein Mutations Linked to Early-Onset Parkinson's Disease: Implications for Pathogenesis and Therapy

Proceedings of the National Academy of Sciences - PNAS, 2000-01, Vol.97 (2), p.571-576

2000

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TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo

Cells (Basel, Switzerland), 2023-06, Vol.12 (12), p.1597

2023

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Effect of spermidine on misfolding and interactions of alpha-synuclein

PloS one, 2012-05, Vol.7 (5), p.e38099

2012

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Tuning a Bisphenol A Lateral Flow Assay Using Multiple Gold Nanosystems

Particle & particle systems characterization, 2019-07, Vol.36 (7), p.n/a

2019

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Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

Molecular neurodegeneration, 2020-09, Vol.15 (1), p.49-23, Article 49

2020

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Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease

Antioxidants, 2023-07, Vol.12 (7), p.1463

2023

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β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6354), p.891-898

2017

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Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

Results in Chemistry, 2023-01, Vol.5, p.100938, Article 100938

2023

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In vitro AMPylation/Adenylylation of Alpha-synuclein by HYPE/FICD

Bio-protocol, 2020-09, Vol.10 (18), p.e3760-e3760

2020

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Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults

Free radical biology & medicine, 2008-08, Vol.45 (3), p.242-255

2008

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Errors in translation act as a “tipping point” leading to the onset of neurodegenerative disease

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease

Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease

Novel therapeutic strategies for the treatment of protein-misfolding diseases

Calcein Release Assay to Measure Membrane Permeabilization by Recombinant Alpha-Synuclein

DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits

Shining a light on autophagy in neurodegenerative diseases

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

New insights into lysosomal dysfunction in parkinson's disease: An emerging role for ATP13A2

Acceleration of Oligomerization, Not Fibrillization, Is a Shared Property of Both α -Synuclein Mutations Linked to Early-Onset Parkinson's Disease: Implications for Pathogenesis and Therapy

TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo

Effect of spermidine on misfolding and interactions of alpha-synuclein

Tuning a Bisphenol A Lateral Flow Assay Using Multiple Gold Nanosystems

Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

In vitro AMPylation/Adenylylation of Alpha-synuclein by HYPE/FICD

Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults

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