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Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

Cellular and molecular life sciences : CMLS, 2007-04, Vol.64 (7-8), p.830-849

2007

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High-Fidelity Physical Organ Simulators: From Artificial to Bio-Hybrid Solutions

IEEE transactions on medical robotics and bionics, 2021-05, Vol.3 (2), p.349-361

2021

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AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2

Biochemical Society transactions, 2003-12, Vol.31 (Pt 6), p.1168

2003

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Molecular biology and biochemistry of pyruvate dehydrogenase complexes

The FASEB journal, 1990-11, Vol.4 (14), p.3224-3233

1990

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Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis

The Journal of clinical investigation, 1998-11, Vol.102 (10), p.1831-1840

1998

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Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex

The Journal of biological chemistry, 1986-02, Vol.261 (4), p.1858-1867

1986

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Identification of the essential cysteine residue in the active site of bovine pyruvate dehydrogenase

The Journal of biological chemistry, 1993-10, Vol.268 (30), p.22353-22356

1993

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Subunit associations in the mammalian pyruvate dehydrogenase complex. Structure and role of protein X and the pyruvate dehydrogenase component binding domain of the dihydrolipoyl transacetylase component

The Journal of biological chemistry, 1989-02, Vol.264 (4), p.2221-2227

1989

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Changes in the core of the mammalian-pyruvate dehydrogenase complex upon selective removal of the lipoyl domain from the transacetylase component but not from the protein X component

The Journal of biological chemistry, 1990-08, Vol.265 (24), p.14512-14517

1990

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Comparative Immunoreactivity of Anti-trifluoroacetyl (TFA) Antibody and Anti-lipoic Acid Antibody in Primary Biliary Cirrhosis: Searching for a Mimic

Journal of autoimmunity, 2000-08, Vol.15 (1), p.51-60

2000

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The catalytic requirements for reduction and acetylation of protein X and the related regulation of various forms of resolved pyruvate dehydrogenase kinase

The Journal of biological chemistry, 1987-07, Vol.262 (21), p.10265-10271

1987

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Separation of Protein X from the Dihydrolipoyl Transacetylase Component of the Mammalian Pyruvate Dehydrogenase Complex and Function of Protein X

The Journal of biological chemistry, 1989-03, Vol.264 (7), p.3655-3657

1989

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Marked Differences between Two Isoforms of Human Pyruvate Dehydrogenase Kinase

The Journal of biological chemistry, 2000-05, Vol.275 (21), p.15773-15781

2000

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Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross‐reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex

Hepatology (Baltimore, Md.), 1989-08, Vol.10 (2), p.127-133

1989

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Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme

The Journal of immunology (1950), 1990-03, Vol.144 (5), p.1671

1990

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Domain structures of the dihydrolipoyl transacetylase and the protein X components of mammalian pyruvate dehydrogenase complex. Selective cleavage by protease Arg C

The Journal of biological chemistry, 1989-01, Vol.264 (2), p.1245-1251

1989

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Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action

The Journal of biological chemistry, 1985-08, Vol.260 (18), p.10146-10152

1985

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Critical Role of a Lipoyl Cofactor of the Dihydrolipoyl Acetyltransferase in the Binding and Enhanced Function of the Pyruvate Dehydrogenase Kinase

Biochemical and biophysical research communications, 1993-02, Vol.190 (3), p.982-991

1993

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Partial activation of the pyruvate dehydrogenase kinase by the lipoyl domain region of E2 and interchange of the kinase between lipoyl domain regions

The Journal of biological chemistry, 1993-12, Vol.268 (35), p.26135-26143

1993

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Cryoelectron microscopy of mammalian pyruvate dehydrogenase complex

The Journal of biological chemistry, 1991-12, Vol.266 (36), p.24650-24656

1991

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Sizing of bovine heart and kidney pyruvate dehydrogenase complex and dihydrolipoyl transacetylase core by quasielastic light scattering

Biochemistry (Easton), 1993-06, Vol.32 (21), p.5629-5637

1993

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Properties of the pyruvate dehydrogenase kinase bound to and separated from the dihydrolipoyl transacetylase-protein X subcomplex and evidence for binding of the kinase to protein X

The Journal of biological chemistry, 1986-05, Vol.261 (14), p.6515-6523

1986

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Specific reactivity of recombinant human PDC-E1α in primary biliary cirrhosis

Journal of autoimmunity, 1991-10, Vol.4 (5), p.769-778

1991

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Role of protein X in the function of the mammalian pyruvate dehydrogenase complex

Biochemical and biophysical research communications, 1989-04, Vol.160 (2), p.715-721

1989

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Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis

The Journal of experimental medicine, 1995-02, Vol.181 (2), p.723-733

1995

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Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

High-Fidelity Physical Organ Simulators: From Artificial to Bio-Hybrid Solutions

AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2

Molecular biology and biochemistry of pyruvate dehydrogenase complexes

Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis

Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex

Identification of the essential cysteine residue in the active site of bovine pyruvate dehydrogenase

Subunit associations in the mammalian pyruvate dehydrogenase complex. Structure and role of protein X and the pyruvate dehydrogenase component binding domain of the dihydrolipoyl transacetylase component

Changes in the core of the mammalian-pyruvate dehydrogenase complex upon selective removal of the lipoyl domain from the transacetylase component but not from the protein X component

Comparative Immunoreactivity of Anti-trifluoroacetyl (TFA) Antibody and Anti-lipoic Acid Antibody in Primary Biliary Cirrhosis: Searching for a Mimic

The catalytic requirements for reduction and acetylation of protein X and the related regulation of various forms of resolved pyruvate dehydrogenase kinase

Separation of Protein X from the Dihydrolipoyl Transacetylase Component of the Mammalian Pyruvate Dehydrogenase Complex and Function of Protein X

Marked Differences between Two Isoforms of Human Pyruvate Dehydrogenase Kinase

Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross‐reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex

Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme

Domain structures of the dihydrolipoyl transacetylase and the protein X components of mammalian pyruvate dehydrogenase complex. Selective cleavage by protease Arg C

Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action

Critical Role of a Lipoyl Cofactor of the Dihydrolipoyl Acetyltransferase in the Binding and Enhanced Function of the Pyruvate Dehydrogenase Kinase

Partial activation of the pyruvate dehydrogenase kinase by the lipoyl domain region of E2 and interchange of the kinase between lipoyl domain regions

Cryoelectron microscopy of mammalian pyruvate dehydrogenase complex

Sizing of bovine heart and kidney pyruvate dehydrogenase complex and dihydrolipoyl transacetylase core by quasielastic light scattering

Properties of the pyruvate dehydrogenase kinase bound to and separated from the dihydrolipoyl transacetylase-protein X subcomplex and evidence for binding of the kinase to protein X

Specific reactivity of recombinant human PDC-E1α in primary biliary cirrhosis

Role of protein X in the function of the mammalian pyruvate dehydrogenase complex

Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis

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